ISSN 1000-3304CN 11-1857/O6

Citation: Hua Yue and Guang-hui Ma. Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines[J]. Acta Polymerica Sinica. doi: 10.11777/j.issn1000-3304.2019.19143 shu

Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines

  • Corresponding author: Guang-hui Ma, ghma@ipe.ac.cn

  • Received Date: 2019-08-02
    Accepted Date: 2019-09-12
    Available Online: 2020-01-01

Figures(7)

  • With the increasing demand for preventing and controlling of new/sudden diseases, major infectious diseases and malignant tumors, vaccines that based on traditional experience await updated. In terms of the unique physio-chemical advantages, polymeric micro/nano particles have become the research hotspots in the field of biomedical delivery. However, the rational integration of the micro/nano particles into vaccine delivery system is a huge challenge. On the basis of our research on the preparation and application of polymer micro/nano particles, an advanced strategy that co-assembles the particle "chassis" and subunit vaccines into one engineered vaccine is proposed. During the 20-year systematic study, new functions of polymeric particles are developed, and important mechanisms for the enhanced cellular/mucosal immunity are clarified. Apart from the chassis with conventional physiochemical property, other chassises with lysosomal escape merit, unique properties (deformability or mobility), or " Immunoticket” advantage have been exploited. The present paper not only summarizes our work but also involves international research progress, which sheds light upon the engineered vaccine chassises for their on-demand design concept, relative mechanism and development
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