Strategies and Applications of Cell Membrane Surface Functionalization of Polymer Materials

Yu-si Liao; Jian-xiao Liang; Zhuan Wen; Ming-ze Cai; Zhang-zhi Song; Ni-yuan Zhang; Hong-wei An; Hao Wang

doi:10.11777/j.issn.1000-3304.2024.24039

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Strategies and Applications of Cell Membrane Surface Functionalization of Polymer Materials

Review | 更新时间：2025-06-17

- Strategies and Applications of Cell Membrane Surface Functionalization of Polymer Materials
- Acta Polymerica Sinica Vol. 55, Issue 5, Pages: 553-572(2024)
- 作者机构：
  
  1.广西医科大学再生医学与医用生物资源开发应用省部共建协同创新中心南宁 530021
  2.国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室北京 100190
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn.1000-3304.2024.24039
  CLC：
- Received：01 February 2024，
  
  Accepted：06 March 2024，
  
  Published Online：27 March 2024，
  
  Published：20 May 2024
- 稿件说明：
移动端阅览
廖宇思, 梁剑箫, 温转, 蔡明泽, 宋张志, 张薿元, 安红维, 王浩. 生物医用高分子材料细胞膜表面功能化的策略与应用. 高分子学报, 2024, 55(5), 553-572

Liao, Y. S.; Liang, J. X.; Wen, Z.; Cai, M. Z.; Song, Z. Z.; Zhang, N. Y.; An, H. W.; Wang, H. Strategies and applications of cell membrane surface functionalization of polymer materials. Acta Polymerica Sinica, 2024, 55(5), 553-572
廖宇思, 梁剑箫, 温转, 蔡明泽, 宋张志, 张薿元, 安红维, 王浩. 生物医用高分子材料细胞膜表面功能化的策略与应用. 高分子学报, 2024, 55(5), 553-572 DOI： 10.11777/j.issn.1000-3304.2024.24039.

Liao, Y. S.; Liang, J. X.; Wen, Z.; Cai, M. Z.; Song, Z. Z.; Zhang, N. Y.; An, H. W.; Wang, H. Strategies and applications of cell membrane surface functionalization of polymer materials. Acta Polymerica Sinica, 2024, 55(5), 553-572 DOI： 10.11777/j.issn.1000-3304.2024.24039.

摘要

细胞膜是细胞的外层包裹结构，保护细胞内部免受外界干扰. 通过对细胞膜进行修饰，引入特定的分子或结构，可以实现对细胞命运和功能的调控，从而赋予细胞特殊的功能. 近年来，利用高分子材料在细胞膜上发生自组装的策略用于功能化修饰细胞膜表面已被广泛研究. 本文综述了利用高分子、多肽及DNA纳米材料对细胞膜进行修饰的策略，总结了其带来的包括受体寡聚化、细胞膜通透性改变以及调节细胞间通讯的生物效应以及细胞膜表面功能化的生物应用.

Abstract

The cell membrane

the outer protective structure of a cell

serves to shield its internal components from external disruptions. By manipulating the cell membrane and incorporating specific molecules or structures

one can exe

rt control over the fate and functionality of cells

thereby imbuing them with specialized functions. In recent years

the strategy of using biomacromolecules to self-assemble on cell membranes has been widely studied for functionalizing the surface of cell membranes. This paper reviews that the self-assembly of different biomacromolecules on the cell membrane surface can change the biological effects of cells and produce positive effects in tumor immunotherapy. It is elaborated that when biomacromolecular materials are self-assembled on the cell membrane

it can cause biological effects of cells

such as oligomerization of cell membrane receptor proteins to activate immune cells

changing cell membrane permeability to promote endocytosis

etc.

At the same time

its application in tumor treatment is briefly introduced

and the future development of self-assembly technology modified cell membrane surface is prospected.

关键词

Keywords

references

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Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University

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Department of Chemistry & Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University

Department of Chemistry and Chemical Engineering, Huanghuai University

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