Self-assembly and Photo-responsive Behavior of Sequence-defined Amphiphilic Azobenzene Alternating Peptoids

Xi-meng Zhu; Dong-xin Zhang; Fan Liu; Peng-chao Wu; Hai-bao Jin; Shao-liang Lin

doi:10.11777/j.issn1000-3304.2024.24156

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Self-assembly and Photo-responsive Behavior of Sequence-defined Amphiphilic Azobenzene Alternating Peptoids

Research Article | 更新时间：2025-01-26

- Self-assembly and Photo-responsive Behavior of Sequence-defined Amphiphilic Azobenzene Alternating Peptoids
- Acta Polymerica Sinica Vol. 56, Issue 1, Pages: 104-113(2025)
- 作者机构：
  
  华东理工大学材料科学与工程学院上海市先进聚合物材料重点实验室上海 200237
- 作者简介：
  
  Hai-bao Jin, E-mail: haibaojin@ecust.edu.cn
  Shao-liang Lin, E-mail: slin@ecust.edu.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2024.24156
  CLC：
- CSTR：32057.14.GFZXB.2024.7275
- Published：20 January 2025，
  
  Published Online：27 September 2024，
  
  Received：05 June 2024，
  
  Accepted：2024-08-19
- 稿件说明：
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朱熹萌, 张栋鑫, 刘帆, 武鹏超, 靳海宝, 林绍梁. 特定序列两亲性偶氮苯交替类肽的自组装与光响应行为研究. 高分子学报, 2025, 56(1), 104-113

Zhu X. M.; Zhang D. X.; Liu F.; Wu P. C.; Jin H. B.; Lin S. L. Self-assembly and photo-responsive behavior of sequence-defined amphiphilic azobenzene alternating peptoids. Acta Polymerica Sinica, 2025, 56(1), 104-113
朱熹萌, 张栋鑫, 刘帆, 武鹏超, 靳海宝, 林绍梁. 特定序列两亲性偶氮苯交替类肽的自组装与光响应行为研究. 高分子学报, 2025, 56(1), 104-113 DOI： 10.11777/j.issn1000-3304.2024.24156. CSTR： 32057.14.GFZXB.2024.7275.

Zhu X. M.; Zhang D. X.; Liu F.; Wu P. C.; Jin H. B.; Lin S. L. Self-assembly and photo-responsive behavior of sequence-defined amphiphilic azobenzene alternating peptoids. Acta Polymerica Sinica, 2025, 56(1), 104-113 DOI： 10.11777/j.issn1000-3304.2024.24156. CSTR： 32057.14.GFZXB.2024.7275.

摘要

刺激响应型序列可控聚合物在传感器、光电器件、信息存储、生物医药等领域中具有广阔的应用前景，因此其精准合成一直是一项极具挑战性的研究课题. 本工作通过固相亚单体合成法，设计并合成了一种新型特定序列结构、光响应的两亲性偶氮苯交替类肽，并通过溶液自组装制备了结构均匀的蠕虫状胶束. 利用耗散粒子动力学模拟，证实了侧链共轭堆积组装机理，及蠕虫状胶束内部两亲性偶氮苯交替类肽的排列方式. 在紫外光和可见光的交替照射下，聚集体能够实现从蠕虫状胶束到球形胶束的可逆光致结构转变. 本研究为刺激响应型序列可控聚合物的自组装研究提供了理论指导.

Abstract

Stimuli-responsive sequence-controlled polymers are capable of making reversible changes in physical and chemical property under external stimuli such as light

heat

electrical fields

and pH

exhibiting significant applications in the fields of sensing

optoelectronics

information storage

and biomedicines. However

the precise synthesis of stimuli-responsive sequence-controlled polymers remains a tremendous challenge. This study reported the design and synthesis of a photo-responsive and sequence-defined amphiphilic azobenzene alternating peptoids (AAAPs) of (NeAzo-

alt

-NEG

)

using the solid-phase sub-monomer synthesis technique. The self-assembly of (NeAzo-

alt

-NEG

)

in the aqueous solution formed uniform worm-like micelles. Dissipative particle dynamics simulations demonstrated the pendants conjugate packing mechanisms and the molecular stacking of AAAPs in the aggregates. The different stage of self-assembly was further confirmed by time-dependent transmission electron microscopy (TEM) characterizations. The self-assembly of AAAPs into uniform worm-like micelles was an active growth procedure from amorphous spherical micelles to crystalline worm-like micelles

with intermediate states of short nanorods. Additionally

the X-ray diffraction patterns further verified the high-crystalline architecture within the worm-like micelles. Ultraviolet-visible (UV-Vis) spectra in aqueous or THF solutions were recorded to unravel the photo-triggered conformation transition of azobenzene units. Under the alternating irradiation with ultraviolet and visible light

a reversible photo-triggered transformation from worm-like micelles to sphe

rical micelles with an average diameter of (67±12) nm was rendered owing to the photo-isomerization of azobenzene units. Our work provides valuable theoretical insights into the self-assembly of stimuli-responsive sequence-controlled polymers.

关键词

两亲性偶氮苯交替类肽固相合成自组装光响应性光致结构转变

Keywords

Amphiphilic azobenzene alternating peptoidsSolid-phase synthesisSelf-assemblyPhoto-responsive capacityPhoto-triggered structural transformation

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