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Recent Progress of Peptide-based Drug Delivery System
- ACTA POLYMERICA SINICA Vol. 53, Issue 5, Pages: 445-456(2022)
- 作者机构：
1.北京科技大学材料科学与工程学院 北京 100083
2.中国科学院纳米科学卓越创新中心 国家纳米科学中心 北京 100190
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2021.21369
CLC：Published：20 May 2022，
Published Online：21 March 2022，
Received：02 December 2021，
Accepted：07 January 2022
- 稿件说明：
移动端阅览
李怡静,龚雪峰,王冬等.基于多肽的药物递送系统研究进展[J].高分子学报,2022,53(05):445-456.
Li Yi-jing,Gong Xue-feng,Wang Dong,et al.Recent Progress of Peptide-based Drug Delivery System[J].ACTA POLYMERICA SINICA,2022,53(05):445-456.
李怡静,龚雪峰,王冬等.基于多肽的药物递送系统研究进展[J].高分子学报,2022,53(05):445-456. DOI： 10.11777/j.issn1000-3304.2021.21369.
Li Yi-jing,Gong Xue-feng,Wang Dong,et al.Recent Progress of Peptide-based Drug Delivery System[J].ACTA POLYMERICA SINICA,2022,53(05):445-456. DOI： 10.11777/j.issn1000-3304.2021.21369.
摘要
药物递送系统是将药物输送到药物作用靶点的系统，理想的递送系统可以提高药物作用效果并降低给药剂量和毒副作用. 本文综述了药物递送系统中的多肽类药物递送系统的研究进展. 多肽具有易合成、易代谢、免疫原性低、毒副作用低等优点，多肽支链上大量的官能团可以和药物偶联，是药物递送系统的重要发展方向. 本文从靶向肽、穿透肽、响应肽和组装肽四个方面介绍了多肽药物递送系统的原理和实例. 组装肽可以形成纳米结构，显著提升多肽药物递送系统的稳定性，可以实现长效释放. 组装肽体内原位调控进一步增加了多肽药物递送系统的智能型、精准性，展现出巨大的转化潜力.
Abstract
Drug delivery system is a system to deliver drugs to targets. An ideal delivery system can improve drug efficacy and reduce drug dosage
toxicity and side effects. This paper reviews the research progress of peptide-based drug delivery systems. Polypeptide (peptide) has the advantages of facile synthesis
easy metabolism
low immunogenicity
low toxicity and side effects. In addition
there are a large number of functional groups on the peptide branch chain
which can be coupled with drugs. Therefore
peptide-based drug delivery system has become an important development direction of drug delivery system
which is introduced from four aspects: targeting peptides
penetrating peptides
response peptides and assembling peptides with the examples and principles. Assembling peptides form nanostructures and enhance the stability of drug delivery system for long-term release.
In vivo
modulation of assembly behavior of peptides increased the intelligence and precise
showing great potential in clinical translation of drug delivery system.
关键词
靶向肽穿透肽响应肽组装肽药物递送
Keywords
Targeting peptidePenetrating peptideResponse peptideAssembling peptideDrug delivery system
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