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Progress of Polymer Microneedles on Transdermal Drug Delivery
- ACTA POLYMERICA SINICA Vol. 53, Issue 8, Pages: 876-893(2022)
- 作者机构：
1.浙江理工大学，材料科学与工程学院，杭州 310018
2.浙江理工大学，智能生物材料与功能纤维国际科技合作基地，杭州 310018
3.浙江理工大学，浙江-毛里求斯生物医用材料与组织工程联合中心，杭州 310018
4.浙江理工大学，生命科学与医药学院，杭州 310018
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2022.22001
CLC：Published：20 August 2022，
Published Online：11 May 2022，
Received：02 January 2022，
Accepted：11 February 2022
- 稿件说明：
移动端阅览
曾志勇,江国华,刘天琦等.聚合物微针药物经皮递送应用研究进展[J].高分子学报,2022,53(08):876-893.
Zeng Zhi-yong,Jiang Guo-hua,Liu Tian-qi,et al.Progress of Polymer Microneedles on Transdermal Drug Delivery[J].ACTA POLYMERICA SINICA,2022,53(08):876-893.
曾志勇,江国华,刘天琦等.聚合物微针药物经皮递送应用研究进展[J].高分子学报,2022,53(08):876-893. DOI： 10.11777/j.issn1000-3304.2022.22001.
Zeng Zhi-yong,Jiang Guo-hua,Liu Tian-qi,et al.Progress of Polymer Microneedles on Transdermal Drug Delivery[J].ACTA POLYMERICA SINICA,2022,53(08):876-893. DOI： 10.11777/j.issn1000-3304.2022.22001.
摘要
微针是一种新型的药物经皮递送技术，能穿透皮肤角质层，形成微孔通道，促进药物的渗透和吸收，在药物递送中有重要作用. 本文从微针的结构和功能特点，系统阐述了聚合物微针的结构和功能设计，以及制造聚合物微针的材料和方法、微针的给药方式；综述了微针经皮递送技术近年来在抗肿瘤、疫苗递送、血糖调控、组织液提取和检测，以及生物传感等领域中的研究进展，并对其优势及存在的问题进行分析，总结了微针技术发展需要解决的关键问题，展望了微针疫苗未来的发展方向.
Abstract
Microneedle (MNs) is a new technology for transdermal drug delivery
which can penetrate the stratum corneum to form micropore channels and promote the penetration and absorption of drugs. Based on the structure and function properties of MNs
the structure and function design of polymer MNs are systematically described in this review. And the materials and methods for the fabrication of polymer MNs and their drug administration are discussed as well. The recent progresses of MNs in anti-tumor
vaccine delivery
blood glucose regulation
tissue fluid extraction and detection are reviewed. The challenge of MNs technology is summarized and the future development trend of MNs is also prospected.
关键词
聚合物微针抗肿瘤疫苗递送血糖调控经皮给药
Keywords
Polymer microneedlesAnti-tumorVaccine deliveryBlood glucose regulationTransdermal drug delivery
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