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Polymeric Materials with J-Stacked Photo-functional Moieties for Disease Diagnosis and Therapy
- ACTA POLYMERICA SINICA Vol. 53, Issue 7, Pages: 769-783(2022)
- 作者机构：
南开大学药物化学生物学国家重点实验室 天津 300071
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2022.22058
CLC：Published：20 July 2022，
Published Online：18 May 2022，
Received：28 February 2022，
Accepted：15 April 2022
- 稿件说明：
移动端阅览
张好,李昌华.光功能基元J-型序构的高分子诊疗材料[J].高分子学报,2022,53(07):769-783.
Zhang Hao,Li Chang-hua.Polymeric Materials with J-Stacked Photo-functional Moieties for Disease Diagnosis and Therapy[J].ACTA POLYMERICA SINICA,2022,53(07):769-783.
张好,李昌华.光功能基元J-型序构的高分子诊疗材料[J].高分子学报,2022,53(07):769-783. DOI： 10.11777/j.issn1000-3304.2022.22058.
Zhang Hao,Li Chang-hua.Polymeric Materials with J-Stacked Photo-functional Moieties for Disease Diagnosis and Therapy[J].ACTA POLYMERICA SINICA,2022,53(07):769-783. DOI： 10.11777/j.issn1000-3304.2022.22058.
摘要
染料分子有序的J-型聚集会产生新的独特光物理性质，使其成为一种构筑高性能疾病诊疗材料的有力手段. 光功能基元J-型序构的高分子诊疗材料充分整合了染料J-聚集体诸多优异的光学性能以及聚合物的响应性、多功能集成性和生物相容性等众多优良特性. 本文主要总结了该领域以本课题组为代表的近期开展的一些研究工作，具体包括：(1)构筑水相稳定的J-聚集体纳米材料，使其在复杂生命体系中保持必要的J-型排列；(2)利用聚合物辅助纳米J-聚集体实现形貌调控与重塑，以提升其肿瘤诊疗性能；(3)聚合物纳米J-聚集体的性能优化与癌症诊疗应用，包括可穿透深层组织的近红外-Ⅱ成像、克服光漂白的光热治疗、疾病标志物激活的精准光动力治疗等. 功能基元J-型序构策略为光诊疗材料的开发带来了新的设计原理和制备方法，为探索具有更高性能的高分子/超分子光功能诊疗材料提供了广阔的设计空间.
Abstract
Controlling dye molecules into a highly ordered J-type sliding arrangement/packing induces exciton coupling to enable new photophysical properties
which makes J-aggregation a powerful tool to construct efficient photoactive materials for disease diagnosis and treatment. In particular
the significant red-shift of absorption and emission peak
enhanced absorbanc
e
and narrowed spectral lines enable deep tissue penetration of photons
high photon utilization
and multi-channels optical diagnosis and therapy
respectively. However
J-aggregates have difficulty in maintaining the necessary dye alignment in complex living settings
impeding their biomedical applications. Furthermore
the difficulty in forming nanostructures with appropriate morphology and size is another obstacle to the
in vivo
applications of J-aggregates. Polymeric nanoassemblies formed by self-assembly of amphiphilic block copolymers have been widely used as drug delivery vehicles due to their intriguing properties
such as stimuli responsiveness
multifunctional integration
and biocompatibility. Therefore
covalent conjugation with polymers and/or encapsulation by polymer assemblies provide an efficient strategy for constructing optical and colloidal stable J-aggregate materials for biological applications. In this review
we summarize recent advances in polymeric materials with J-stacked dyes for disease diagnosis and therapy
including: (i) establishing facile strategies to construct water-stable polymeric or supramolecular J-aggregate nanomaterials to maintain the necessary J-type arrangement in complex living systems
(ii) developing robust methods to remodel J-aggregates nanoassemblies with the assistance of polymers to obtain nano J-aggregates with desired morphology and size to improve their
in vivo
performances in tumor diagnosis and therapy
and (iii) devising and constructing novel polymeric nano-J-aggregates with remarkable performances in cancer diagnostic and therapeutic applications
such as near-infrared-Ⅱ imaging agents with high tissue penetration depth
non-photobleaching photothermal agents for cancer photothermal therapy
and activatable photosensitizers in response to disease biomarkers for precise photodynamic therapy. In light of the unique photophysical and photochemical properties of J-aggregates and fascinating properties of polymers
this new
type of polymeric materials with J-stacked photo-functional moieties bring new design principles and preparation methods for the development of phototherapeutic materials
and opens a gateway to the explore polymer/supramolecular phototherapeutic materials with higher performance.
关键词
光活性功能高分子诊疗高分子材料非共价键作用J-聚集分子自组装
Keywords
Photoactive functional polymerDiagnostic and therapeutic polymer materialNoncovalent interactionJ-aggregationMolecular self-assembly
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