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Recent Advances of Polymers with Aggregation-induced Emission Characteristics in Phototheranostics
- ACTA POLYMERICA SINICA Vol. 53, Issue 7, Pages: 856-872(2022)
- 作者机构：
1.深圳大学材料学院 AIE研究中心 深圳 518060
2.香港中文大学(深圳)理工学院 深圳 518172
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2022.22079
CLC：Published：20 July 2022，
Published Online：06 June 2022，
Received：11 March 2022，
Revised：11 April 2022，
- 稿件说明：
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李丹,孙盼盼,李建高等.聚集诱导发光高分子在光学诊疗应用中的研究进展[J].高分子学报,2022,53(07):856-872.
Li Dan,Sun Pan-pan,Li Jian-gao,et al.Recent Advances of Polymers with Aggregation-induced Emission Characteristics in Phototheranostics[J].ACTA POLYMERICA SINICA,2022,53(07):856-872.
李丹,孙盼盼,李建高等.聚集诱导发光高分子在光学诊疗应用中的研究进展[J].高分子学报,2022,53(07):856-872. DOI： 10.11777/j.issn1000-3304.2022.22079.
Li Dan,Sun Pan-pan,Li Jian-gao,et al.Recent Advances of Polymers with Aggregation-induced Emission Characteristics in Phototheranostics[J].ACTA POLYMERICA SINICA,2022,53(07):856-872. DOI： 10.11777/j.issn1000-3304.2022.22079.
摘要
高分子因其优异的光学特性、良好的生物相容性和分子结构易于调控等优势，在光学诊疗领域表现出巨大应用潜力. 然而，传统荧光分子的聚集导致荧光淬灭现象限制了其生物应用. 聚集诱导发光(AIE)分子因其聚集态高效发光的优势而备受关注. 本文从AIE高分子的构建出发，重点介绍了D-A型共轭聚合物的构建策略、构-效关系以及相对于小分子的性能和应用优势，并从生物成像、肿瘤诊疗和抗菌三个方面总结了AIE高分子在光学诊疗领域的最新研究进展. 生物成像方面主要总结了NIR-II区AIE高分子在深部组织高分辨率荧光成像中的应用；肿瘤诊疗方面主要介绍了AIE高分子在光动力治疗、光热治疗及联合治疗中的应用；以及介绍了AIE高分子在细菌感染光动力治疗中的应用. 最后对AIE高分子在光学诊疗领域的未来发展前景进行了展望.
Abstract
Phototheranostics
as an emerging treatment integrating the functions of light-driven diagnostic imaging and therapy
has aroused extensive attention for both fundamental research and clinical application in recent years because of its advantages of high temporal and spatial selectivity
low side effects
small trauma and high controllability. The conjugated polymers have distinct advantages including excellent optical properties
easy chemical structure regulation
good biocompatibility and solution processability
showing great potential application in the field of phototheranostics. However
traditional fluorescent molecules including the conjugated polymers suffer from the phenomenon of aggregation-caused quenching (ACQ) in aggregate state resulted from their rigid planar structures
thus hindering their biological applications. Luminogens with aggregation-induced emission (AIE) characteristics have attracted much attention because of their high fluorescence quantum efficiency in aggregate. This review is aimed to summarize the state-of-the-art advancements of AIE polymers in phototheranostics
especially the D-A type conjugated polymers
involving the construction strategies of AIE polymers and their applications in three aspects of biological imaging
tumor diagnosis and therapy
and bacterial eradication. According to the practical applications
the different requirements of construction strategies for AIE polymers
as well as the comparisons of the structure and properties advantages between the small molecules and polymers are also discussed. For biological imaging
the review is mainly focused on the development of AIE polymers with NIR-II fluorescence emission and high brightness to achieve high-resolution fluorescence imaging in deep tissues. In the aspect of tumor diagnosis and treatment
the review illustrates the AIE polymers with great advantages compared with small molecules in photon absorption and photosensitization performance
and their applications in photodynamic therapy
photothermal therapy and combined therapy. Also
the applications of AIE polymers for photodynamic therapy of bacterial infections are illustrated. Although the development of AIE polymers have lagged behind that of small molecules mainly due to their complex molecular structures and more difficult AIE mechanism studies
it is necessary to pay more attention to pushing forward the studies on AIE polymers and having in-depth understanding about structure-properties relationship. Additionally
the future development in the field of AIE polymers is prospected at the end of this review.
关键词
聚集诱导发光高分子光学诊疗
Keywords
Aggregation-induced emissionPolymerPhototheranostics
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