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Peptide-based Assemblies and Their Application in Photothermal Immunotherapy of Cancer
- ACTA POLYMERICA SINICA Vol. 53, Issue 10, Pages: 1173-1186(2022)
- 作者机构：
1.中国科学院过程工程研究所 生化工程国家重点实验室 北京 100190
2.中国科学院大学化学工程学院 北京 100049
3.中国科学院过程工程研究所 介尺度科学研究中心 北京 100190
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2022.22221
CLC：Published：20 October 2022，
Published Online：24 August 2022，
Received：03 June 2022，
Accepted：18 July 2022
- 稿件说明：
移动端阅览
刘亚洲,邢蕊蕊,闫学海.寡肽组装体及其肿瘤光热免疫治疗应用[J].高分子学报,2022,53(10):1173-1186.
Liu Ya-zhou,Xing Rui-rui,Yan Xue-hai.Peptide-based Assemblies and Their Application in Photothermal Immunotherapy of Cancer[J].ACTA POLYMERICA SINICA,2022,53(10):1173-1186.
刘亚洲,邢蕊蕊,闫学海.寡肽组装体及其肿瘤光热免疫治疗应用[J].高分子学报,2022,53(10):1173-1186. DOI： 10.11777/j.issn1000-3304.2022.22221.
Liu Ya-zhou,Xing Rui-rui,Yan Xue-hai.Peptide-based Assemblies and Their Application in Photothermal Immunotherapy of Cancer[J].ACTA POLYMERICA SINICA,2022,53(10):1173-1186. DOI： 10.11777/j.issn1000-3304.2022.22221.
摘要
光热治疗与免疫治疗功能上的互补以及协同效应使得光热免疫治疗在抑制实体瘤及转移瘤方面具有非常优异的表现，然而当前使用的光热免疫制剂的局限性限制了其临床应用转化，对于这种复合疗法的开发和优化已经成为肿瘤治疗领域的研究热点. 其中，基于寡肽分子设计的功能组装体获得了越来越多的关注，这类组装体不仅可以通过氨基酸编码设计组装结构，而且可以通过生物活性肽的引入实现优异的抗肿瘤治疗性能. 本专论中将根据寡肽分子参与抗肿瘤体系构建的不同作用，结合本团队的研究进展，对近期寡肽组装体在肿瘤光热免疫治疗的研究进行总结. 首先探讨了寡肽参与光热免疫体系组装调控的思路，阐述了组装调控过程中寡肽在强化体系稳定性、优化光热转化效率及诱导免疫应答的机理. 此外，还结合国内外研究现状，对不同功能肽在肿瘤光热免疫治疗中的作用进行了总结，并分析了寡肽组装体在肿瘤治疗领域的应用前景，最后对该领域的发展方向进行了展望.
Abstract
With the complementary and synergistic effects on anticancer function
the combined utilization of photothermal therapy and immunotherapy is one of the priority methods for eliminating solid tumor and metastatic tumor. However
the limitations of photothermal immunoagents currently in use bring drawbacks to their clinical application prospects. The development and optimization of this combined therapy have become a research hotspot in the field of cancer treatment. More and more attention has been paid to functional assemblies based on oligopeptide molecular design. Such assemblies can not only design the assembly structure through amino acid encoding
but also achieve excellent anti-tumor therapeutic performance through the introduction of bioactive peptides. In this feature article
we summarize the recent researches on oligopeptide-based assemblies for tumor photothermal immunotherapy in terms of the different roles of peptide molecules in the construction of assembly system. We first discuss the roles of oligopeptides participating in the assembly regulation of photothermal immune system
and then elaborate the mechanisms of oligopeptides in optimizing system stability
enhancing photothermal conversion efficiency
and inducing immune response in the assembly process. In addition
we also summarize the roles of different functional peptides in photothermal immunotherapy of cancer
and discuss the application prospect of oligopeptide assembly in cancer therapy.
关键词
寡肽色素超分子自组装功能组装体光热免疫疗法
Keywords
PeptideChromophoreSupramolecular self-assemblyFunctional assembliesPhotothermal immunotherapy
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