Synthesis and Application of DNA-Organic Small Molecule Complex

Jian-han Ye; Fen Wu; Yuan-chen Dong; Li-jin Xu; Dong-sheng Liu

doi:10.11777/j.issn1000-3304.2022.22281

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Synthesis and Application of DNA-Organic Small Molecule Complex

Rapid Communication | 更新时间：2024-10-08

- Synthesis and Application of DNA-Organic Small Molecule Complex
  增强出版
- ACTA POLYMERICA SINICA Vol. 53, Issue 12, Pages: 1421-1428(2022)
- 作者机构：
  
  1.中国人民大学化学系北京 100872
  2.中国科学院化学研究所北京 100190
  3.温州大学化学与材料工程学院温州 325035
  4.生命有机磷化学及化学生物学教育部重点实验室清华大学化学系北京 100084
- 作者简介：
  
  Fen Wu, E-mail: wufen@wzu.edu.cn
  Li-jin Xu, E-mail: 20050062@ruc.edu.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2022.22281
  CLC：
- Published：20 December 2022，
  
  Received：19 August 2022，
  
  Accepted：23 September 2022
- 稿件说明：
移动端阅览
叶建涵,吴芬,董原辰等.DNA-有机小分子复合结构的合成及应用研究[J].高分子学报,2022,53(12):1421-1428.

Ye Jian-han,Wu Fen,Dong Yuan-chen,et al.Synthesis and Application of DNA-Organic Small Molecule Complex[J].ACTA POLYMERICA SINICA,2022,53(12):1421-1428.
叶建涵,吴芬,董原辰等.DNA-有机小分子复合结构的合成及应用研究[J].高分子学报,2022,53(12):1421-1428. DOI： 10.11777/j.issn1000-3304.2022.22281.

Ye Jian-han,Wu Fen,Dong Yuan-chen,et al.Synthesis and Application of DNA-Organic Small Molecule Complex[J].ACTA POLYMERICA SINICA,2022,53(12):1421-1428. DOI： 10.11777/j.issn1000-3304.2022.22281.

摘要

探索并比较了DNA与有机小分子化合物在固相合成和液相偶联中的反应效率，利用DNA固相合成的方法高效的合成了多种DNA-有机小分子的复合结构，通过基质辅助激光解吸-飞行时间质谱(MALDI-TOF)对其结构和分子量进行了表征；并利用透射电子显微镜和动态光散射对DNA-芘复合结构在水相中的组装行为进行了初步的探索，其组装结构有望应用于药物的包裹释放研究.

Abstract

We explore and compare the reaction efficiency of DNA with organic small molecule compounds in solid-phase synthesis and solution coupling. Multiple DNA-organic small molecule complex structures have been synthesized efficiently by the method of DNA solid-phase synthesis

whose structures and molecular weights are characterized by matrix-assisted laser desorption-time of flight mass spectrometry (MALDI-TOF). Then

the assembling behaviors of DNA-pyrene complex in aqueous phase have been explored by transmission electron microscopy and dynamic light scattering

whose assemblies are expected to be applied to the study of drug package release.

关键词

DNA固相合成液相偶联自组装

Keywords

DNASolid-phase synthesisSolution couplingAssembly

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