Flexible Fiber Glucose Sensor Based on Direct Electron Transfer

Jin-yan Li; Cheng-qiang Tang; Wen-jun Li; Tao Huang; Xue-mei Sun; Hui-sheng Peng

doi:10.11777/j.issn1000-3304.2024.24010

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Flexible Fiber Glucose Sensor Based on Direct Electron Transfer

Research Article | 更新时间：2024-09-25

- Flexible Fiber Glucose Sensor Based on Direct Electron Transfer
- Acta Polymerica Sinica Vol. 55, Issue 7, Pages: 872-880(2024)
- 作者机构：
  
  聚合物分子工程国家重点实验室复旦大学高分子科学系纤维电子材料与器件研究院先进材料实验室上海 200438
- 作者简介：
  
  Xue-mei Sun, E-mail: sunxm@fudan.edu.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2024.24010
  CLC：
- Published：20 July 2024，
  
  Published Online：10 April 2024，
  
  Received：13 January 2024，
  
  Accepted：19 February 2024
- 稿件说明：
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李金妍, 唐成强, 李雯君, 黄滔, 孙雪梅, 彭慧胜. 基于直接电子转移的柔性纤维葡萄糖传感器. 2024, 55(7), 872-880

Li, J. Y.; Tang, C. Q.; Li, W. J.; Huang, T.; Sun, X. M.; Peng, H. S. Flexible fiber glucose sensor based on direct electron transfer. Acta Polymerica Sinica, 2024, 55(7), 872-880
李金妍, 唐成强, 李雯君, 黄滔, 孙雪梅, 彭慧胜. 基于直接电子转移的柔性纤维葡萄糖传感器. 2024, 55(7), 872-880 DOI： 10.11777/j.issn1000-3304.2024.24010.

Li, J. Y.; Tang, C. Q.; Li, W. J.; Huang, T.; Sun, X. M.; Peng, H. S. Flexible fiber glucose sensor based on direct electron transfer. Acta Polymerica Sinica, 2024, 55(7), 872-880 DOI： 10.11777/j.issn1000-3304.2024.24010.

摘要

酶基电化学葡萄糖传感器具有优异的选择性和灵敏度，基于直接电子转移原理的第三代传感器有望解决第一、二代传感器所面临的易受氧气浓度干扰、电子介体不稳定等问题. 因此，本研究基于聚3

4-乙烯二氧噻吩:聚苯乙烯磺酸盐(PEDOT:PSS)和葡萄糖脱氢酶(GDH)双组分开发了柔性纤维第三代葡萄糖传感器. 该纤维传感器在10~500 μmol/L范围内具有良好的线性(

=0.9968)，灵敏度可达62.53 μA/(mmol·L

-1

·cm

)，且不受氧气影响. 纤维传感器还具有良好的柔性和可编织性，将其集成到织物中，实现了人在运动时汗液中葡萄糖的连续实时监测，为制备满足可穿戴需求的第三代葡萄糖传感器提供了新思路.

Abstract

Real-time monitor

ing of glucose concentration

in vivo

holds significant importance for disease diagnosis and treatment. The enzyme-based electrochemical glucose sensor has garnered considerable attention in the realm of real-time glucose monitoring due to its outstanding selectivity and sensitivity. Despite the development of first and second generation electrochemical glucose sensors

they encounter numerous challenges derived from their sensing principles

including interference from oxygen concentration

instability of electronic mediators

and leaching toxicity. The third generation of glucose sensor based on direct electron transfer between enzyme and electrode is anticipated to address these challenges. Here

we report an all-polymer-based flexible fiber glucose sensor (FGS) based on direct electron transfer

leveraging poly(3

‍4-vinyldioxythiophene):‍polystyrene sulfonate (PEDOT:PSS) and glucose dehydrogenase (GDH) as its constituents. The FGS exhibits commendable linearity (

=0.9968) within the range of 10-500 μmol/L and demonstrates a sensitivity of 62.53 μA/(mmol·L

-1

·cm

). The FGS is seamlessly integrated into fabric

enabling continuous real-time monitoring of glucose levels in human sweat during exercise. This work presents a novel approach for developing the third-generation glucose sensors to cater to the requirements of wearable technology.

关键词

柔性纤维葡萄糖传感器直接电子转移汗液监测聚34-乙烯二氧噻吩:聚苯乙烯磺酸盐

Keywords

Flexible fiberGlucose sensorDirect electron transferSweat monitoringPoly(34-vinyldioxythiophene):polystyrene sulfonate

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