Biomedical Polymer Nanomotor Chemotactic System: A New Generation of Drug Delivery System

Xue Xia; Chun Mao; Mi-mi Wan

doi:10.11777/j.issn1000-3304.2025.24311

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Biomedical Polymer Nanomotor Chemotactic System: A New Generation of Drug Delivery System

Feature Article | 更新时间：2025-06-13

- Biomedical Polymer Nanomotor Chemotactic System: A New Generation of Drug Delivery System
- Acta Polymerica Sinica Vol. 56, Issue 6, Pages: 861-880(2025)
- 作者机构：
  
  生物医药功能材料国家地方联合工程研究中心南京师范大学化学与材料科学学院南京 210023
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2025.24311
  CLC：
- CSTR：32057.14.GFZXB.2025.7363
- Received：29 December 2024，
  
  Accepted：17 February 2025，
  
  Published Online：13 May 2025，
  
  Published：20 June 2025
- 稿件说明：
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夏雪, 毛春, 万密密. 生物医用高分子纳米马达趋化体系：新一代药物递送载体. 高分子学报, 2025, 56(6), 861-880

Xia, X.; Mao, C.; Wan, M. M. Biomedical polymer nanomotor chemotactic system: a new generation of drug delivery system. Acta Polymerica Sinica, 2025, 56(6), 861-880
夏雪, 毛春, 万密密. 生物医用高分子纳米马达趋化体系：新一代药物递送载体. 高分子学报, 2025, 56(6), 861-880 DOI： 10.11777/j.issn1000-3304.2025.24311. CSTR： 32057.14.GFZXB.2025.7363.

Xia, X.; Mao, C.; Wan, M. M. Biomedical polymer nanomotor chemotactic system: a new generation of drug delivery system. Acta Polymerica Sinica, 2025, 56(6), 861-880 DOI： 10.11777/j.issn1000-3304.2025.24311. CSTR： 32057.14.GFZXB.2025.7363.

摘要

纳米马达是一类可沿化学物质浓度梯度矢量场进行定向运动的新型纳米材料，其特有的趋化运动性能可望为药物的精准递送带来新的效应. 然而，受限于疾病的复杂微环境，构建可有效趋化靶向病变组织的纳米马达趋化体系依然面临挑战. 作者团队结合高分子纳米材料的独特优势，在发展新策略构建高分子纳米马达趋化体系方面取得了一系列创新成果. 本专论从高分子纳米马达趋化体系的构建方法出发，重点阐述了一类可在体内疾病微环境发生趋化运动的高分子纳米马达的通用型构建策略，总结归纳了它们与不同治疗剂的组装规律及其在重大疾病治疗中的相关机制，并对该领域未来的发展方向进行展望.

Abstract

The chemotactic system of nanomotor is a new kind of nanomaterial that can move along the concentration gradient vector field of chemical substances. Its unique chemotactic movement performance is expected to bring new effects for the efficient and accurate delivery of drugs. However

due to the complex disease microenvironment within the body

constructing a nanomotor chemotactic system that can effectively target disease tissues remains a challenge. Combining the unique advantages of polymer nanomaterials

the author's team has made a

series of innovative achievements in developing new strategies to build polymer nanomotor chemotatic systems and developing new methods to assemble them with therapeutic agents. Starting from the construction method of polymer nanomotor chemotactic system

this monograph focuses on the general construction strategy of a kind of polymer nanomotor that can move in the disease microenvironment

in vivo

summarizes their assembly strategies with different therapeutic agents and their related mechanisms in the treatment of a variety of major diseases

and prospects the future development direction of this field.

关键词

Keywords

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