Synthesis of Dipropyl-protected Cyclic Lysine Monomer and Antibacterial Properties of Quaternized Polymer

Yan Yan; Qun-liang Zhang; You-hua Tao

doi:10.11777/j.issn1000-3304.2025.25029

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Synthesis of Dipropyl-protected Cyclic Lysine Monomer and Antibacterial Properties of Quaternized Polymer

Research Article | 更新时间：2025-07-08

- Synthesis of Dipropyl-protected Cyclic Lysine Monomer and Antibacterial Properties of Quaternized Polymer
- Acta Polymerica Sinica Vol. 56, Issue 7, Pages: 1150-1158(2025)
- 作者机构：
  
  1.中国科学院长春应用化学研究所高分子科学与技术重点实验室生态环境高分子材料重点实验室长春 130022
  2.中国科学技术大学应用化学与工程学院合肥 230026
- 作者简介：
  
  Qun-liang Zhang, E-mail: zhangqunliang@ciac.ac.cn
  You-hua Tao, E-mail: youhua.tao@ciac.ac.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2025.25029
  CLC：
- CSTR：32057.14.GFZXB.2025.7393
- Received：28 January 2025，
  
  Accepted：03 April 2025，
  
  Published Online：13 May 2025，
  
  Published：20 July 2025
- 稿件说明：
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闫岩, 张群亮, 陶友华. 二丙基环状赖氨酸单体合成及其季铵盐聚合物抗菌性能研究. 高分子学报, 2025, 56(7), 1150-1158

Yan, Y.; Zhang, Q. L.; Tao, Y. H. Synthesis of dipropyl-protected cyclic lysine monomer and antibacterial properties of quaternized polymer. Acta Polymerica Sinica, 2025, 56(7), 1150-1158
闫岩, 张群亮, 陶友华. 二丙基环状赖氨酸单体合成及其季铵盐聚合物抗菌性能研究. 高分子学报, 2025, 56(7), 1150-1158 DOI： 10.11777/j.issn1000-3304.2025.25029. CSTR： 32057.14.GFZXB.2025.7393.

Yan, Y.; Zhang, Q. L.; Tao, Y. H. Synthesis of dipropyl-protected cyclic lysine monomer and antibacterial properties of quaternized polymer. Acta Polymerica Sinica, 2025, 56(7), 1150-1158 DOI： 10.11777/j.issn1000-3304.2025.25029. CSTR： 32057.14.GFZXB.2025.7393.

摘要

细菌感染对人类健康造成严重威胁，细菌耐药性问题已经成为全球公共卫生的重大挑战，因此发展新型、高效的抗菌材料势在必行. 抗菌聚氨基酸由于具有广谱高效的抗菌活性、不易产生耐药性以及可生物降解等优点，而受到广泛关注. 本研究以丰富的生物资源赖氨酸为原料，利用可模块化反应的环状赖氨酸合成了二丙基环状赖氨酸(DPCL)单体. 通过阴离子开环聚合制备的聚合物poly(DPCL)在季铵化后得到阳离子聚合物. 所得到的阳离子聚合物对大肠杆菌(

E. coli

)和金黄色葡萄球菌(

S. aureus

)表现出显著的抗菌效果，并且具有良好的生物相容性，使其成为具有广阔应用潜力的抗菌聚氨基酸材料.

Abstract

Bacterial infections pose a serious threat to human health

and the emergence of bacterial resistance has become a major challenge to global public health. Therefore

it is crucial to develop novel and efficient antibacterial materials. Antimicrobial polyaminoacids are gaining considerable attention due to their broad-spectrum antibacterial activity

high efficiency

resistance to bacterial drug resistance

and biodegradability. In this study

a dipropyl-protected cyclic lysine (DPCL) monomer was synthesized from lysine

a biologically abundant resource

utilizing cyclic lysine

which facilitates modular reactions. The quaternized poly(DPCL)

a cationic polymer prepared through anionic ring-opening polymerization of DPCL followed by quaternization

demonstrated significant antibacterial activity against

Escherichia coli

(

E. coli

) and

Staphylococcus aureus

(

S. aureus

)

along with good biocompatibility. These properties endow it with broad application potential as an antibacterial polyaminoacid material.

关键词

Keywords

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