Phase Separation Regulation and Performance of PET Hollow Fiber Membranes Based on Dichloromethane/Hexafluoroisopropanol Mixed Solvents

En-ting Xu; Xiao-jun Yao; Xue-yuan Yang; Lei Fang; Wei Bao; Kuan-jun Fang

doi:10.11777/j.issn1000-3304.2025.25061

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Phase Separation Regulation and Performance of PET Hollow Fiber Membranes Based on Dichloromethane/Hexafluoroisopropanol Mixed Solvents

Research Article | 更新时间：2025-07-28

- Phase Separation Regulation and Performance of PET Hollow Fiber Membranes Based on Dichloromethane/Hexafluoroisopropanol Mixed Solvents
- Acta Polymerica Sinica Vol. 56, Issue 8, Pages: 1369-1382(2025)
- 作者机构：
  
  1.青岛大学，纺织服装学院，青岛 266071
  2.青岛大学，生态纺织省部共建协同创新中心，青岛 266071
  3.青岛大学，生物多糖纤维成型与生态纺织国家重点实验室，青岛 266071
- 作者简介：
  
  Kuan-jun Fang, E-mail: kjfang@qdu.edu.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2025.25061
  CLC：
- CSTR：32057.14.GFZXB.2025.7409
- Received：03 March 2025，
  
  Accepted：30 April 2025，
  
  Published Online：10 July 2025，
  
  Published：20 August 2025
- 稿件说明：
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徐恩婷, 姚晓军, 杨雪媛, 房磊, 包伟, 房宽峻. 基于二氯甲烷/六氟异丙醇溶剂体系的聚对苯二甲酸乙二酯中空纤维膜相分离调控与性能. 高分子学报, 2025, 56(8), 1369-1382

Xu, E. T.; Yao, X. J.; Yang, X. Y.; Fang, L.; Bao, W.; Fang, K. J. Phase separation regulation and performance of PET hollow fiber membranes based on dichloromethane/hexafluoroisopropanol mixed solvents. Acta Polymerica Sinica, 2025, 56(8), 1369-1382
徐恩婷, 姚晓军, 杨雪媛, 房磊, 包伟, 房宽峻. 基于二氯甲烷/六氟异丙醇溶剂体系的聚对苯二甲酸乙二酯中空纤维膜相分离调控与性能. 高分子学报, 2025, 56(8), 1369-1382 DOI： 10.11777/j.issn1000-3304.2025.25061. CSTR： 32057.14.GFZXB.2025.7409.

Xu, E. T.; Yao, X. J.; Yang, X. Y.; Fang, L.; Bao, W.; Fang, K. J. Phase separation regulation and performance of PET hollow fiber membranes based on dichloromethane/hexafluoroisopropanol mixed solvents. Acta Polymerica Sinica, 2025, 56(8), 1369-1382 DOI： 10.11777/j.issn1000-3304.2025.25061. CSTR： 32057.14.GFZXB.2025.7409.

摘要

聚对苯二甲酸乙二醇酯(PET)因为具有优异的力学性能和化学稳定性而在分离膜领域有着广泛的应用，此外作为大口径人工血管的关键材料，将其应用于制备小口径人造血管极具优势. 但它在常温条件下难以溶解的性质限制了它的生产和发展. 本研究通过构建二氯甲烷(DCM)与六氟异丙醇(HFIP)混合溶剂体系，探究PET在室温条件下的溶解行为，将PET溶解时间从24 h 缩短至0.5 h，并借助诱导PET发生旋节线相分离(spinodal decomposition)抑制指状孔的形成，使膜的平均孔径由1.58 μm 降低为0.87 μm. 研究表明，适量的DCM (10%~20%)增强了膜的机械性能和过滤性能，为高性能中空纤维膜及其在小口径人工血管骨架中的应用提供了新策略.

Abstract

Polyethylene terephthalate (PET) exhibits not only outstanding mechanical properties and chemical stability

but also benefits from industrial-scale availability

cost-effectiveness

and ease of recycling. PET has significant potential for the development of small-diameter vascular grafts as a key material for clinically used large-diameter artificial blood vessels. However

its limited solubility at room temperature has hindered its application in wet-spinning. To address this challenge

a binary solvent system comprising dichloromethane (DCM) and hexafluoroisopropanol (HFIP) was employed to achieve rapid dissolution of PET under mild conditions. The DCM-HFIP system markedly accelerated the dissolution process

reducing the required time from 24 h to 0.5 h at ambient temperature (25 ℃‍). Furthermore

the incorporation of DCM enhances the stability of the solvent system

while enabling precise control over the phase separation pathway. Spinodal phase separation was induced by modulating the DCM content

effectively suppressing the formation of finger-like pores and promoting a bicontinuous pore structure. This structural optimization reduces the average membrane pore size from 1.58 μm to 0.87 μm. Experimental results confirm that an optimal DCM volume fraction (10%-20%) significantly improves the membrane's mechanical strength and filtration efficiency

accompanied by a moderate reduction in surface roughness. This study provides a green and efficient strategy for fabricating high-performance PET hollow fiber membranes and establishes a theoretical foundation for their future biomedical applications

particularly in the development of small-diameter artificial vascular scaffolds. Notably

the proven biocompatibility of PET in large-diameter vascular grafts

combined with the biomimetic hollow lumen structure that closely resembles the natural human vasculature

positions this research as a pioneering pathway for advancing next-generation small-diameter artificial blood vessels.

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references

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En-ting Xu

Xiao-jun Yao

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Kuan-jun Fang

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Collaborative Innovation Center for Eco-textiles of Shandong Province and the Ministry of Education

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