Ring-opening Metathesis Polymerization-induced Self-assembly

Ting-ting Xu; Mu-zhou Li; Xin Hu; Ning Zhu

doi:10.11777/j.issn1000-3304.2026.26009

您当前的位置：

首页 >

文章列表页 >

Ring-opening Metathesis Polymerization-induced Self-assembly

Review | 更新时间：2026-06-02

- Ring-opening Metathesis Polymerization-induced Self-assembly
- Acta Polymerica Sinica Vol. 57, Issue 6, Pages: 1243-1259(2026)
- 作者机构：
  
  1.南京工业大学生物与制药工程学院材料化学工程全国重点实验室南京 211800
  2.南京工业大学材料科学与工程学院南京 211800
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2026.26009
  CLC：
- CSTR：32057.14.GFZXB.2026.7574
- Received：15 January 2026，
  
  Accepted：12 March 2026，
  
  Online First：15 May 2026，
  
  Published：20 June 2026
- 稿件说明：
移动端阅览
徐婷婷, 李牧舟, 胡欣, 朱宁. 开环易位聚合诱导自组装. 高分子学报, 2026, 57(6), 1243-1259.

Xu, T. T.; Li, M. Z.; Hu, X.; Zhu, N. Ring-opening metathesis polymerization-induced self-assembly. Acta Polymerica Sinica (in Chinese), 2026, 57(6), 1243-1259.
徐婷婷, 李牧舟, 胡欣, 朱宁. 开环易位聚合诱导自组装. 高分子学报, 2026, 57(6), 1243-1259. DOI： 10.11777/j.issn1000-3304.2026.26009. CSTR： 32057.14.GFZXB.2026.7574.

Xu, T. T.; Li, M. Z.; Hu, X.; Zhu, N. Ring-opening metathesis polymerization-induced self-assembly. Acta Polymerica Sinica (in Chinese), 2026, 57(6), 1243-1259. DOI： 10.11777/j.issn1000-3304.2026.26009. CSTR： 32057.14.GFZXB.2026.7574.

摘要

聚合诱导自组装(PISA)已成为一种高效合成固含量高、形貌多样纳米颗粒的新方法，在高分子化学和纳米材料等领域引起了广泛关注. 近年来，面向环烯烃单体的开环易位聚合(ROMP)具有可控性好、官能团耐受性高、适配大位阻单体等优势，越来越多地应用于聚合诱导自组装领域，成功获得系列主链含有不饱和双键的聚合物纳米颗粒. 本综述聚焦开环易位聚合诱导自组装(ROMPISA)，从有机相、水相和有机/水相三个方面，总结开环易位聚合诱导自组装在纳米颗粒形貌控制、功能调控以及应用等方面的研究进展，同时探讨了相关领域存在的机遇与挑战，希望为聚合诱导自组装领域的发展提供借鉴.

Abstract

Polymerization-induced self-assembly (PISA) has emerged as a highly efficient strategy for the synthesis of high-solid-content nano-objects with diverse morphologies

which has attracted growing interest in polymer chemistry and nanomaterials. In recent years

the ring-opening metathesis polymerization (ROMP) of cyclic olefin monomers has been used in PISA because of its good controllability

high tolerance for functional groups

and availability for sterically hindered monomers. Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) has been demonstrated as a powerful platform for the preparation of a series of polyolefin block copolymer nano-objects containing unsaturated double bonds in the main chain. This review focuses on the advances in ring-opening metathesis polymerization-induced self-assembly. The morphologies

functions

and applications of nano-objects from ROMPISA are summarized from the perspectives of the organic

aqueous

and organic/aqueous phases

respectively. Challenges and opportunities are discussed to provide insights into the further development of polymerization-induced self-assembly.

关键词

Keywords

references

Derry M. J. ; Fielding L. A. ; Armes S. P. Polymerization-induced self-assembly of block copolymer nanoparticles via RAFT non-aqueous dispersion polymerization . Prog. Polym. Sci. , 2016 , 52 , 1 - 18 . doi: 10.1016/j.progpolymsci.2015.10.002 http://dx.doi.org/10.1016/j.progpolymsci.2015.10.002

Canning S. L. ; Smith G. N. ; Armes S. P. A critical appraisal of RAFT-mediated polymerization-induced self-assembly . Macromolecules , 2016 , 49 ( 6 ), 1985 - 2001 . doi: 10.1021/acs.macromol.5b02602 http://dx.doi.org/10.1021/acs.macromol.5b02602

Lowe A. B. RAFT alcoholic dispersion polymerization with polymerization-induced self-assembly . Polymer , 2016 , 106 , 161 - 181 . doi: 10.1016/j.polymer.2016.08.082 http://dx.doi.org/10.1016/j.polymer.2016.08.082

Charleux B. ; Delaittre G. ; Rieger J. ; D'Agosto F. Polymerization-induced self-assembly: from soluble macromolecules to block copolymer nano-objects in one step . Macromolecules , 2012 , 45 ( 17 ), 6753 - 6765 . doi: 10.1021/ma300713f http://dx.doi.org/10.1021/ma300713f

Liu C. ; Hong C. Y. ; Pan C. Y. Polymerization techniques in polymerization-induced self-assembly (PISA) . Polym. Chem. , 2020 , 11 ( 22 ), 3673 - 3689 . doi: 10.1039/d0py00455c http://dx.doi.org/10.1039/d0py00455c

Penfold N. J. W. ; Yeow J. ; Boyer C. ; Armes S. P. Emerging trends in polymerization-induced self-assembly . ACS Macro Lett. , 2019 , 8 ( 8 ), 1029 - 1054 . doi: 10.1021/acsmacrolett.9b00464 http://dx.doi.org/10.1021/acsmacrolett.9b00464

Cao J. P. ; Tan Y. X. ; Chen Y. ; Zhang L. ; Tan J. B. Expanding the scope of polymerization-induced self-assembly: recent advances and new horizons . Macromol. Rapid Commun. , 2021 , 42 ( 23 ), 2100498 . doi: 10.1002/marc.202100498 http://dx.doi.org/10.1002/marc.202100498

Niu B. ; Chen Y. ; Zhang L. ; Tan J. B. Organic-inorganic hybrid nanomaterials prepared via polymerization-induced self-assembly: recent developments and future opportunities . Polym. Chem. , 2022 , 13 ( 18 ), 2554 - 2569 . do i: 10.1039/d2py00180b http://dx.doi.org/10.1039/d2py00180b

Wan J. ; Fan B. ; Thang S. H. RAFT-mediated polymerization-induced self-assembly (RAFT-PISA): current status and future directions . Chem. Sci. , 2022 , 13 ( 15 ), 4192 - 4224 . doi: 10.1039/d2sc00762b http://dx.doi.org/10.1039/d2sc00762b

D'Agosto F. ; Rieger J. ; Lansalot M. RAFT-mediated polymerization-induced self-assembly . Angew. Chem. Int. Ed. , 2020 , 59 ( 22 ), 8368 - 8392 . doi: 10.1002/anie.201911758 http://dx.doi.org/10.1002/anie.201911758

Wang X. ; An Z. S. New insights into RAFT dispersion polymerization-induced self-assembly: from monomer library , morphological control, and stability to driving forces. Macromol. Rapid Commun., 2019 , 40 ( 2 ), 1800325 . doi: 10.1002/marc.201800325 http://dx.doi.org/10.1002/marc.201800325

Xu C. ; Zheng M. X. ; Wei Y. ; Yuan J. Y. Liquid crystalline nanoparticles via polymerization-induced self-assembly: morphology evolution and function regulation . Chem. , 2024 , 30 ( 15 ), e 202303586 . doi: 10.1002/chem.202303586 http://dx.doi.org/10.1002/chem.202303586

Zhang H. W. ; Han W. J. ; Liu Y. H. ; Hu X. ; Zhu N. ; Guo K. Stimuli responsive nano-objects via polymerization induced self-assembly . Acta Polym. Sin. , 2023 , 54 ( 11 ), 1663 - 1680 .

Pei Y. W. ; Lowe A. B. ; Roth P. J. Stimulus-responsive nanoparticles and associated (reversible) polymorphism via polymerization induced self-assembly (PISA) . Macromol. Rapid Commun. , 2017 , 38 , 1600528 . doi: 10.1002/marc.201600528 http://dx.doi.org/10.1002/marc.201600528

Wan Z. Y. ; An N. K. ; Xu C. ; Zheng M. X. ; Yuan J. Y. Polymerization-induced self-assembly nanomaterials based on dynamic covalent bonds . Polym. Chem. , 2025 , 16 ( 6 ), 636 - 651 . doi: 10.1039/d4py01204f http://dx.doi.org/10.1039/d4py01204f

Zhang S. D. ; Li R. Y. ; An Z. S. Degradable block copolymer nanoparticles synthesized by polymerization-induced self-assembly . Angew. Chem. Int. Ed. , 2024 , 63 ( 12 ), e 202315849 . doi: 10.1002/anie.202315849 http://dx.doi.org/10.1002/anie.202315849

Neal T. J. ; Dalmasso L. ; Coumes F. ; Rieger J. UV-degradable poly(phenyl vinyl ketone) particles produced by polymerisation-induced self-assembly in ethanol or water . Polym. Chem. , 2026 , 17 ( 3 ), 332 - 340 . doi: 10.1039/d5py01020a http://dx.doi.org/10.1039/d5py01020a

Farmer M. A. H. ; Musa O. M. ; Armes S. P. Efficient synthesis of hydrolytically degradable block copolymer nanoparticles via reverse sequence polymerization-induced self-assembly in aqueous media . Angew. Chem. Int. Ed. , 2023 , 62 ( 38 ), e 202309526 . doi: 10.1002/anie.202309526 http://dx.doi.org/10.1002/anie.202309526

Sugihara S. ; Sugihara nee Nishikawa K. ; Armes S. P. ; Ahmad H. ; Lewis A. L. Synthesis of biomimetic poly(2-(methacryloyloxy)ethyl phosphorylcholine) nanolatexes via atom transfer radical dispersion polymerization in alcohol/water mixtures . Macromolecules , 2010 , 43 ( 15 ), 6321 - 6329 . doi: 10.1021/ma101136v http://dx.doi.org/10.1021/ma101136v

Wang G. W. ; Schmitt M. ; Wang Z. Y. ; Lee B. ; Pan X. C. ; Fu L. Y. ; Yan J. J. ; Li S. P. ; Xie G. J. ; Bockstaller M. R. ; Matyjaszewski K. Polymerization-induced self-assembly (PISA) using ICAR ATRP at low catalyst concentration . Macromolecules , 2016 , 49 ( 22 ), 8605 - 8615 . doi: 10.1021/acs.macromol.6b01966 http://dx.doi.org/10.1021/acs.macromol.6b01966

Wang G. W. ; Wang Z. Y. ; Lee B. ; Yuan R. ; Lu Z. ; Yan J. J. ; Pan X. C. ; Song Y. ; Bockstaller M. R. ; Matyjaszewski K. Polymerization-induced self-assembly of acrylonitrile via ICAR ATRP . Polymer , 2017 , 129 , 57 - 67 . doi: 10.1016/j.polymer.2017.09.029 http://dx.doi.org/10.1016/j.polymer.2017.09.029

Shi B. Y. ; Zhang H. ; Liu Y. ; Wang J. ; Zhou P. ; Cao M. Y. ; Wang G. W. Development of ICAR ATRP-based polymerization-induced self-assembly and its application in the preparation of organic-inorganic nanoparticles . Macromol. Rapid Commun. , 2019 , 40 ( 24 ), 1900547 . doi: 10.1002/marc.201900547 http://dx.doi.org/10.1002/marc.201900547

Simakova A. ; Averick S. E. ; Konkolewicz D. ; Matyjaszewski K. Aqueous arget atrp . Macromolecules , 2012 , 45 ( 16 ), 6371 - 6379 . doi: 10.1021/ma301303b http://dx.doi.org/10.1021/ma301303b

Cao Y. L. ; Shi Y. ; Wu X. H. ; Zhang L. Q. Preparation of ABA triblock copolymer assemblies through "one-pot" RAFT PISA . Chinese Chemical Lett. , 2020 , 31 ( 6 ), 1660 - 1664 . doi: 10.1016/j.cclet.2019.10.026 http://dx.doi.org/10.1016/j.cclet.2019.10.026

Yang S. Q. ; Zhang L. ; Chen Y. ; Tan J. B. Combining green light-activated photoiniferter RAFT polymerization and RAFT dispersion polymerization for graft copolymer assemblies . Macromolecules , 2022 , 55 ( 19 ), 8472 - 8484 . doi: 10.1021/acs.macromol.2c01529 http://dx.doi.org/10.1021/acs.macromol.2c01529

Zhang Y. X. ; Yu L. L. ; Dai X. C. ; Zhang L. ; Tan J. B. Structural difference in macro-RAFT agents redirects polymerization-induced self-assembly . ACS Macro Lett. , 2019 , 8 ( 9 ), 1102 - 1109 . doi: 10.1021/acsmacrolett.9b00509 http://dx.doi.org/10.1021/acsmacrolett.9b00509

Yu M. G. ; Tan J. B. ; Yang J. W. ; Zeng Z. H. Z-type and R-type macro-RAFT agents in RAFT dispersion polymerization—another mechanism perspective on PISA . Polym. Chem. , 2016 , 7 ( 22 ), 3756 - 3765 . doi: 10.1039/c6py00605a http://dx.doi.org/10.1039/c6py00605a

Wang J. ; Hu X. ; Zhu N. ; Guo K. Continuous flow photo-RAFT and light-PISA . Chem. Eng. J. , 2021 , 420 , 127663 . doi: 10.1016/j.cej.2020.127663 http://dx.doi.org/10.1016/j.cej.2020.127663

Delaittre G. ; Nicolas J. ; Lefay C. ; Save M. ; Charleux B. Surfactant-free synthesis of amphiphilic diblock copolymer nanoparticles via nitroxide-mediated emulsion polymerization . Chem. Commun. , 2005 ( 5 ), 614 - 616 . doi: 10.1039/b415959d http://dx.doi.org/10.1039/b415959d

Qiao X. G. ; Lansalot M. ; Bourgeat-Lami E. ; Charleux B. Nitroxide-mediated polymerization-induced self-assembly of poly(poly(ethylene oxide) methyl ether methacrylate- co -styrene)- b -poly( n -butyl methacrylate- co -styrene) amphiphilic block copolymers . Macromolecules , 2013 , 46 ( 11 ), 4285 - 4295 . doi: 10.1021/ma4003159 http://dx.doi.org/10.1021/ma4003159

Yoshida E. Preparation of giant vesicles containing quaternary ammonium salt of 2-(dimethylamino)ethyl methacrylate through photo nitroxide-mediated controlled/living radical polymerization-induced self-assembly . J. Polym. Res. , 2018 , 25 ( 5 ), 109 . doi: 10.1007/s10965-018-1509-3 http://dx.doi.org/10.1007/s10965-018-1509-3

Yoshida E. Preparation of giant vesicles supporting hindered amine on their shells through photo living radical polymerization-induced self-assembly . J. Dispers. Sci. Technol. , 2020 , 41 ( 5 ), 763 - 770 . doi: 10.1080/01932691.2019.1617163 http://dx.doi.org/10.1080/01932691.2019.1617163

Delaittre G. ; Dire C. ; Rieger J. ; Putaux J. L. ; Charleux B. Formation of polymer vesicles by simultaneous chain growth and self-assembly of amphiphilic block copolymers . Chem. Commun. , 2009 , ( 20 ), 2887 - 2889 . doi: 10.1039/b903040a http://dx.doi.org/10.1039/b903040a

Su M. ; Sheng Y. J. ; Chen Y. J. ; Li T. ; Shi Q. X. ; Xiao H. ; Pu M. Q. ; Bao H. L. ; Wan W. M. Living covalent-anionic-radical polymerization via a barbier strategy . ACS Macro Lett. , 2022 , 11 ( 3 ), 354 - 361 . doi: 10.1021/acsmacrolett.2c00010 http://dx.doi.org/10.1021/acsmacrolett.2c00010

Wang J. ; Cao M. Y. ; Zhou P. ; Wang G. W. Exploration of a living anionic polymerization mechanism into polymerization-induced self-assembly and site-specific stabilization of the formed nano-objects . Macromolecules , 2020 , 53 ( 8 ), 3157 - 3165 . doi: 10.1021/acs.macromol.0c00371 http://dx.doi.org/10.1021/acs.macromol.0c00371

Zhou C. C. ; Wang J. ; Zhou P. ; Wang G. W. A polymerization-induced self-assembly process for all-styrenic nano-objects using the living anionic polymerization mechanism . Polym. Chem. , 2020 , 11 ( 15 ), 2635 - 2639 . doi: 10.1039/D0PY00296H http://dx.doi.org/10.1039/D0PY00296H

Beauseroy H. ; Grazon C. ; Antoine S. ; Badreldin M. ; Salas-Ambrosio P. ; Harrisson S. ; Garanger E. ; Lecommandoux S. ; Bonduelle C. Polypeptide- and protein-based conjugate nanoparticles via aqueous ring-opening polymerization-induced self-assembly (ROPISA) . Macromol. Rapid Commun. , 2024 , 45 ( 14 ), 2400079 . doi: 10.1002/marc.202400079 http://dx.doi.org/10.1002/marc.202400079

Grazon C. ; Salas-Ambrosio P. ; Ibarboure E. ; Buol A. ; Garanger E. ; Grinstaff M. W. ; Lecommandoux S. ; Bonduelle C. Aqueous ring-opening polymerization-induced self-assembly (ROPISA) of N -carboxyanhydrides . Angew. Chem. Int. Ed. , 2020 , 59 ( 2 ), 622 - 626 . doi: 10.1002/anie.201912028 http://dx.doi.org/10.1002/anie.201912028

Jiang J. H. ; Zhu Y. Q. ; Du J. Z. Challenges and perspective on ring-opening polymerization-induced self-assembly . Acta Chim. Sinica , 2020 , 78 ( 8 ), 719 . doi: 10.6023/a20050162 http://dx.doi.org/10.6023/a20050162

Beauseroy H. ; Salimi F. ; Aujard-Catot J. ; Alembik L. ; Lecommandoux S. ; Bonduelle C. Aqueous ring-opening polymerization-induced self-assembly (ROPISA): tailoring anisotropic nanoparticles through amino acid N -carboxyanhydride (NCA) monomer selection . Macromolecules , 2025 , 58 ( 13 ), 6466 - 6479 . doi: 10.1021/acs.macromol.5c01089 http://dx.doi.org/10.1021/acs.macromol.5c01089

Yao S. M. ; Yang J. J. ; Yang J. ROPISA of salicylic acid O -carboxyanhydride: fast polymerization followed by in situ kinetics-driven self-assembly . Polym. Chem. , 2023 , 14 ( 30 ), 3493 - 3500 . doi: 10.1039/d3py00550j http://dx.doi.org/10.1039/d3py00550j

Zhao X. P. ; Sun C. R. ; Xiong F. ; Wang T. ; Li S. ; Huo F. W. ; Yao X. K. Polymerization-induced self-assembly for efficient fabrication of biomedical nanoplatforms . Research , 2023 , 6 , 113 . doi: 10.34133/research.0113 http://dx.doi.org/10.34133/research.0113

Purohit V. B. ; Pięta M. ; Patel D. M. ; Pietrasik J. ; Plummer C. M. Recent developments in ring-opening metathesis polymerization-induced self-assembly (ROMPISA) . Eur. Polym. J. , 2025 , 223 , 113666 . doi: 10.1016/j.eurpolymj.2024.113666 http://dx.doi.org/10.1016/j.eurpolymj.2024.113666

Zhang Y. X. ; He J. ; Dai X. C. ; Yu L. L. ; Tan J. B. ; Zhang L. Combining the power of heat and light: temperature-programmed photoinitiated RAFT dispersion polymerization to tune polymerization-induced self-assembly . Polym. Chem. , 2019 , 10 ( 28 ), 3902 - 3911 . doi: 10.1039/c9py00534j http://dx.doi.org/10.1039/c9py00534j

Lei L. ; De Rancourt de Mimérand, Y. ; Le Droumaguet B. ; Couturaud B. Enzyme-responsive sugar methacrylate-based nanoparticles synthesized by RAFT-PISA . ACS Sustainable Chem. Eng. , 2025 , 13 ( 30 ), 12311 - 12322 . doi: 10.1021/acssuschemeng.5c05504 http://dx.doi.org/10.1021/acssuschemeng.5c05504

György C. ; Armes S. P. Recent advances in polymerization-induced self-assembly (PISA) syntheses in non-polar media . Angew. Chem. Int. Ed. , 2023 , 62 ( 42 ), e 202308372 . doi: 10.1002/anie.202308372 http://dx.doi.org/10.1002/anie.202308372

He J. ; Chen Y. ; Zhang L. ; Tan J. B. Oxidation-responsive framboidal triblock copolymer vesicles prepared by photoinitiated RAFT seeded emulsion polymerization . Chinese Chem. Lett. , 2023 , 34 ( 3 ), 107344 . doi: 10.1016/j.cclet.2022.03.067 http://dx.doi.org/10.1016/j.cclet.2022.03.067

郑晋文 , 王晓 , 安泽胜 . RAFT聚合诱导自组装制备不同嵌段序列氧化响应性聚合物囊泡 . 高分子学报 , 2019 , 50 ( 11 ), 1167 - 1176 . doi: 10.11777/j.issn1000-3304.2019.19070 http://dx.doi.org/10.11777/j.issn1000-3304.2019.19070

Wang L. ; Ding Y. ; Liu Q. Z. ; Zhao Q. Q. ; Dai X. C. ; Lu X. H. ; Cai Y. L. Sequence-controlled polymerization-induced self-assembly . ACS Macro Lett. , 2019 , 8 ( 5 ), 623 - 628 . doi: 10.1021/acsmacrolett.9b00305 http://dx.doi.org/10.1021/acsmacrolett.9b00305

Armes S. P. ; Perrier S. ; Zetterlund P. B. Introduction to polymerisation-induced self assembly . Polym. Chem. , 2021 , 12 ( 1 ), 8 - 11 . doi: 10.1039/d0py90190c http://dx.doi.org/10.1039/d0py90190c

Blanazs A. ; Verber R. ; Mykhaylyk O. O. ; Ryan A. J. ; Heath J. Z. ; Ian Douglas C. W. ; Armes S. P. Sterilizable gels from thermoresponsive block copolymer worms . J. Am. Chem. Soc. , 2012 , 134 ( 23 ), 9741 - 9748 . doi: 10.1021/ja3024059 http://dx.doi.org/10.1021/ja3024059

Ye Q. Q. ; Huo M. ; Zeng M. ; Liu L. ; Peng L. ; Wang X. S. ; Yuan J. Y. Photoinduced reversible worm-to-vesicle transformation of azo-containing block copolymer assemblies prepared by polymerization-induced self-assembly . Macromolecules , 2018 , 51 ( 9 ), 3308 - 3314 . doi: 10.1021/acs.macromol.8b00340 http://dx.doi.org/10.1021/acs.macromol.8b00340

Li D. ; Huo M. ; Liu L. ; Zeng M. ; Chen X. ; Wang X. S. ; Yuan J. Y. Overcoming kinetic trapping for morphology evolution during polymerization-induced self-assembly . Macromol. Rapid Commun. , 2019 , 40 ( 16 ), 1900202 . doi: 10.1002/marc.201900202 http://dx.doi.org/10.1002/marc.201900202

Qiu L. ; Zhang H. R. ; Wang B. ; Zhan Y. ; Xing C. F. ; Pan C. Y. CO 2 -responsive nano-objects with assembly-related aggregation-induced emission and tunable morphologies . ACS Appl. Mater. Interfaces , 2020 , 12 ( 1 ), 1348 - 1358 . doi: 10.1021/acsami.9b18792 http://dx.doi.org/10.1021/acsami.9b18792

Zehm D. ; Ratcliffe L. P. D. ; Armes S. P. Synthesis of diblock copolymer nanoparticles via RAFT alcoholic dispersion polymerization: effect of block copolymer composition , molecular weight, copolymer concentration, and solvent type on the final particle morphology. Macromolecules, 2013 , 46 ( 1 ), 128 - 139 . doi: 10.1021/ma301459y http://dx.doi.org/10.1021/ma301459y

Kuperkar K. ; Patel D. ; Atanase L. I. ; Bahadur P. Amphiphilic block copolymers: their structures, and self-assembly to polymeric micelles and polymersomes as drug delivery vehicles . Polymers , 2022 , 14 ( 21 ), 4702 . doi: 10.3390/polym14214702 http://dx.doi.org/10.3390/polym14214702

Cao C. ; Chen F. ; Garvey C. J. ; Stenzel M. H. Drug-directed morphology changes in polymerization-induced self-assembly (PISA) influence the biological behavior of nanoparticles . ACS Appl. Mater. Interfaces , 2020 , 12 ( 27 ), 30221 - 30233 . doi: 10.1021/acsami.0c09054 http://dx.doi.org/10.1021/acsami.0c09054

Zhang Q. C. ; Wang R. M. ; Chen Y. ; Zhang L. ; Tan J. B. Block copolymer vesicles with tunable membrane thicknesses and compositions prepared by aqueous seeded photoinitiated polymerization-induced self-assembly at room temperature . Langmuir , 2022 , 38 ( 8 ), 2699 - 2710 . doi: 10.1021/acs.langmuir.1c03430 http://dx.doi.org/10.1021/acs.langmuir.1c03430

Khor S. Y. ; Vu M. N. ; Pilkington E. H. ; Johnston A. P. R. ; Whittaker M. R. ; Quinn J. F. ; Truong N. P. ; Davis T. P. Elucidating the influences of size , surface chemistry, and dynamic flow on cellular association of nanoparticles made by polymerization-induced self-assembly. Small, 2018 , 14 ( 34 ), 1801702 . doi: 10.1002/smll.201801702 http://dx.doi.org/10.1002/smll.201801702

Esser L. ; Truong N. P. ; Karagoz B. ; Moffat B. A. ; Boyer C. ; Quinn J. F. ; Whittaker M. R. ; Davis T. P. Gadolinium-functionalized nanoparticles for application as magnetic resonance imaging contrast agents via polymerization-induced self-assembly . Polym. Chem. , 2016 , 7 ( 47 ), 7325 - 7337 . doi: 10.1039/c6py01797e http://dx.doi.org/10.1039/c6py01797e

Bielawski C. ; Grubbs R. Highly efficient ring-opening metathesis polymerization (ROMP) using new ruthenium catalysts containing N -heterocyclic carbene ligands . Angew. Chem. Int. Ed. , 2000 , 39 ( 16 ), 2903 - 2906 . doi: 10.1002/1521-3773(20000818)39:16<2903::aid-anie2903>3.0.co;2-q http://dx.doi.org/10.1002/1521-3773(20000818)39:16<2903::aid-anie2903>3.0.co;2-q

Bielawski C. W. ; Grubbs R. H. Living ring-opening metathesis polymerization . Prog. Polym. Sci. , 2007 , 32 ( 1 ), 1 - 29 . doi: 10.1016/j.progpolymsci.2006.08.006 http://dx.doi.org/10.1016/j.progpolymsci.2006.08.006

Grubbs R. H. ; Burk P. L. ; Carr D. D. Mechanism of the olefin metathesis reaction . J. Am. Chem. Soc. , 1975 , 97 ( 11 ), 3265 - 3267 . doi: 10.1021/ja00844a082 http://dx.doi.org/10.1021/ja00844a082

Chemtob A. ; Héroguez V. ; Gnanou Y. Dispersion ring-opening metathesis polymerization of norbornene using PEO-based stabilizers . Macromolecules , 2002 , 35 ( 25 ), 9262 - 9269 . doi: 10.1021/ma020871o http://dx.doi.org/10.1021/ma020871o

Chemtob A. ; Héroguez V. ; Gnanou Y. Synthesis of polybutadiene-based particles via dispersion ring-opening metathesis polymerization . J. Polym. Sci. A Polym. Chem. , 2004 , 42 ( 5 ), 1154 - 1163 . doi: 10.1002/pola.11048 http://dx.doi.org/10.1002/pola.11048

Haschick R. ; Klapper M. ; Wagener K. B. ; Müllen K. Nanoparticles by ROMP in nonaqueous emulsions . Macromol. Chem. Phys. , 2010 , 211 ( 24 ), 2547 - 2554 . doi: 10.1002/macp.201000389 http://dx.doi.org/10.1002/macp.201000389

Fan F. ; Cai C. ; Gao L. ; Li J. ; Zhang P. ; Li G. Y. ; Li C. X. ; Yu G. L. Microwave-assisted synthesis of glycopolymers by ring-opening metathesis polymerization (ROMP) in an emulsion system . Polym. Chem. , 2017 , 8 ( 44 ), 6709 - 6719 . doi: 10.1039/c7py01415e http://dx.doi.org/10.1039/c7py01415e

Quémener D. ; Chemtob A. ; Héroguez V. ; Gnanou Y. Synthesis of latex particles by ring-opening metathesis polymerization . Polymer , 2005 , 46 ( 4 ), 1067 - 1075 . doi: 10.1016/j.polymer.2004.11.096 http://dx.doi.org/10.1016/j.polymer.2004.11.096

Schaefer M. ; Hanik N. ; Kilbinger A. F. M. ROMP copolymers for orthogonal click functionalizations . Macromolecules , 2012 , 45 ( 17 ), 6807 - 6818 . doi: 10.1021/ma301061z http://dx.doi.org/10.1021/ma301061z

Eissa A. M. ; Khosravi E. Comb-like graft copolymers of poly(oxa)norbornene: efficient synthesis using a combination of ROMP and click chemistry . Macromol. Chem. Phys. , 2015 , 216 ( 9 ), 964 - 976 . doi: 10.1002/macp.201400604 http://dx.doi.org/10.1002/macp.201400604

Fursule I. A. ; Abtahi A. ; Watkins C. B. Jr , Graham, K. R.; Berron, B. J. In situ crosslinking of surface-initiated ring opening metathesis polymerization of polynorbornene for improved stability. J. Colloid Interface Sci., 2018 , 510 , 86 - 94 . doi: 10.1016/j.jcis.2017.09.050 http://dx.doi.org/10.1016/j.jcis.2017.09.050

Weaver J. A. ; Morelly S. L. ; Alvarez N. J. ; Magenau A. J. D. Grafting-through ROMP for gels with tailorable moduli and crosslink densities . Polym. Chem. , 2018 , 9 ( 42 ), 5173 - 5178 . doi: 10.1039/c8py01324a http://dx.doi.org/10.1039/c8py01324a

Chen J. ; Sun R. Y. ; Liao X. J. ; Han H. J. ; Li Y. W. ; Xie M. R. Tandem metathesis polymerization-induced self-assembly to nanostructured block copolymer and the controlled triazolinedione modification for enhancing dielectric properties . Macromolecules , 2018 , 51 ( 24 ), 10202 - 10213 . doi: 10.1021/acs.macromol.8b01645 http://dx.doi.org/10.1021/acs.macromol.8b01645

Scholl M. ; Ding S. ; Lee C. W. ; Grubbs R. H. Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1 , 3 -dimesityl-4,5 -dihydroimidazol-2-ylidene ligands . Org. Lett., 1999, 1 ( 6 ), 953 - 956 . doi: 10.1021/ol990909q http://dx.doi.org/10.1021/ol990909q

Trnka, T. M.; Grubbs , R. H. The development of L 2 X 2 RuCHR olefin metathesis catalysts: an organometallic success story. Acc. Chem. Res., 2001 , 34 ( 1 ), 18 - 29 .

Schrock R. R. Recent advances in high oxidation state Mo and W imido alkylidene chemistry . Chem. Rev. , 2009 , 109 ( 8 ), 3211 - 3226 . doi: 10.1021/cr800502p http://dx.doi.org/10.1021/cr800502p

Benedikter M. J. ; Ziegler F. ; Groos J. ; Hauser P. M. ; Schowner R. ; Buchmeiser M. R. Group 6 metal alkylidene and alkylidyne N -heterocyclic carbene complexes for olefin and alkyne metathesis . Coord. Chem. Rev. , 2020 , 415 , 213315 . doi: 10.1016/j.ccr.2020.213315 http://dx.doi.org/10.1016/j.ccr.2020.213315

Schrock R. R. High-oxidation-state molybdenum and tungsten alkylidyne complexes . Acc. Chem. Res. , 1986 , 19 ( 11 ), 342 - 348 . doi: 10.1021/ar00131a003 http://dx.doi.org/10.1021/ar00131a003

Huang J. K. ; Stevens E. D. ; Nolan S. P. ; Petersen J. L. Olefin metathesis-active ruthenium complexes bearing a nucleophilic carbene ligand . J. Am. Chem. Soc. , 1999 , 121 ( 12 ), 2674 - 2678 . doi: 10.1021/ja9831352 http://dx.doi.org/10.1021/ja9831352

Choi T. L. ; Grubbs R. H. Controlled living ring-opening-metathesis polymerization by a fast-initiating ruthenium catalyst . Angew. Chem. Int. Ed. , 2003 , 42 ( 15 ), 1743 - 1746 . doi: 10.1002/anie.200250632 http://dx.doi.org/10.1002/anie.200250632

Vougioukalakis G. C. ; Grubbs R. H. Ruthenium-based heterocyclic carbene-coordinated olefin metathesis catalysts . Chem. Rev. , 2010 , 110 ( 3 ), 1746 - 1787 . doi: 10.1021/cr9002424 http://dx.doi.org/10.1021/cr9002424

Stewart I. C. ; Douglas C. J. ; Grubbs R. H. Increased efficiency in cross-metathesis reactions of sterically hindered olefins . Org. Lett. , 2008 , 10 ( 3 ), 441 - 444 . doi: 10.1021/ol702624n http://dx.doi.org/10.1021/ol702624n

Zhang L. Y. ; Song C. M. ; Yu J. H. ; Yang D. ; Xie M. R. One-pot synthesis of polymeric nanoparticle by ring-opening metathesis polymerization . J. Polym. Sci. A Polym. Chem. , 2010 , 48 ( 22 ), 5231 - 5238 . doi: 10.1002/pola.24323 http://dx.doi.org/10.1002/pola.24323

Liu J. W. ; Liao Y. ; He X. H. ; Yu J. H. ; Ding L. ; Xie M. R. Facile one-pot approach for preparing functionalized polymeric nanoparticles via ROMP . Macromol. Chem. Phys. , 2011 , 212 ( 1 ), 55 - 63 . doi: 10.1002/macp.201000416 http://dx.doi.org/10.1002/macp.201000416

Lim J. ; Choi Y. ; Kang E. H. ; Yang S. ; Pyun J. ; Choi T. L. ; Char K. A one-pot synthesis of polysulfane-bearing block copolymer nanoparticles with tunable size and refractive index . Chem. Commun. , 2016 , 52 ( 12 ), 2485 - 2488 . doi: 10.1039/c5cc08490c http://dx.doi.org/10.1039/c5cc08490c

Wright D. B. ; Touve M. A. ; Adamiak L. ; Gianneschi N. C. ROMPISA: ring-opening metathesis polymerization-induced self-assembly . ACS Macro Lett. , 2017 , 6 ( 9 ), 925 - 929 . doi: 10.1021/acsmacrolett.7b00408 http://dx.doi.org/10.1021/acsmacrolett.7b00408

Le D. ; Dilger M. ; Pertici V. ; Diabaté S. ; Gigmes D. ; Weiss C. ; Delaittre G. Ultra-fast synthesis of multivalent radical nanoparticles by ring-opening metathesis polymerization-induced self-assembly . Angew. Chem. Int. Ed. , 2019 , 58 ( 14 ), 4725 - 4731 . doi: 10.1002/anie.201813434 http://dx.doi.org/10.1002/anie.201813434

Mei H. G. ; Zhao B. J. ; Wang H. M. ; Zheng S. X. Crosslinked polydicyclopentadiene nanoparticles via ring-opening metathesis polymerization-induced self-assembly approach . Macromol. Rapid Commun. , 2021 , 42 ( 14 ), 2100155 . doi: 10.1002/marc.202100155 http://dx.doi.org/10.1002/marc.202100155

Mei H. G. ; Hu J. W. ; Gao Y. ; Li L. ; Zheng S. X. Incorporation of crosslinked polydicyclopentadiene nanoparticles into epoxy thermosets via ring opening metathesis polymerization-induced self-assembly . Polymer , 2022 , 255 , 125160 . doi: 10.1016/j.polymer.2022.125160 http://dx.doi.org/10.1016/j.polymer.2022.125160

Hou W. M. ; Yin X. Z. ; Zhou Y. Q. ; Zhou Z. ; Liu Z. J. ; Du J. Z. ; Shi Y. ; Chen Y. M. Kinetically controlled preparation of worm-like micelles with tunable diameter/length and structural stability . J. Am. Chem. Soc. , 2024 , 146 ( 34 ), 24094 - 24104 . doi: 10.1021/jacs.4c08206 http://dx.doi.org/10.1021/jacs.4c08206

Hunter C. A. ; Sanders J. K. M. The nature of π - π interactions . J. Am. Chem. Soc. , 1990 , 112 ( 14 ), 5525 - 5534 . doi: 10.1021/ja00170a016 http://dx.doi.org/10.1021/ja00170a016

Zhu R. M. ; Chang Z. X. ; Zhang W. J. ; Hong C. Y. Polymerization-induced self-assembly with assistance of aromatic interactions facilitates the formation of polymeric nanotubes . Macromolecules , 2023 , 56 ( 9 ), 3296 - 3303 . doi: 10.1021/acs.macromol.3c00302 http://dx.doi.org/10.1021/acs.macromol.3c00302

Yoon K. Y. ; Lee I. H. ; Kim K. O. ; Jang J. ; Lee E. and Choi, T. L. One-pot in situ fabrication of stable nanocaterpillars directly from polyacetylene diblock copolymers synthesized by mild ring opening metathesis polymerization . J. Am. Chem. Soc . 2012 , 134 ( 35 ), 14291 - 14294 . doi: 10.1021/ja305150c http://dx.doi.org/10.1021/ja305150c

Yoon K. Y. ; Shin S. ; Kim Y. J. ; Kim I. ; Lee E. ; Choi T. L. One-pot preparation of 3D nano- and microaggregates via in situ nanoparticlization of polyacetylene diblock copolymers produced by ROMP . Macromol. Rapid Commun. , 2015 , 36 ( 11 ), 1069 - 1074 . doi: 10.1002/marc.201400649 http://dx.doi.org/10.1002/marc.201400649

Yoon K. Y. ; Lee I. H. ; Choi T. L. Preparation of defect-free nanocaterpillars via in situ nanoparticlisation of a well-defined polyacetylene block copolymer . RSC Adv. , 2014 , 4 ( 90 ), 49180 - 49185 . doi: 10.1039/c4ra10325d http://dx.doi.org/10.1039/c4ra10325d

MacFarlane L. ; Zhao C. Q. ; Cai J. D. ; Qiu H. B. ; Manners I. Emerging applications for living crystallization-driven self-assembly . Chem. Sci. , 2021 , 12 ( 13 ), 4661 - 4682 . doi: 10.1039/d0sc06878k http://dx.doi.org/10.1039/d0sc06878k

Nie J. Q. ; Zhao J. T. ; Li L. N. ; Zhou T. Y. ; Guerin G. Crystallization-driven self-assembly- substrated -polymerization-induced self-assembly (CDSA- s -PISA) . toward the next generation of supercarriers. Angew. Chem. Int. Ed. , 2025 , 64 ( 39 ), e 202511515 . doi: 10.1002/anie.202511515 http://dx.doi.org/10.1002/anie.202511515

Sha Y. ; Rahman M. A. ; Zhu T. Y. ; Cha Y. J. ; McAlister C. W. ; Tang C. B. ROMPI-CDSA: ring-opening metathesis polymerization-induced crystallization-driven self-assembly of metallo-block copolymers . Chem. Sci. , 2019 , 10 ( 42 ), 9782 - 9787 . doi: 10.1039/C9SC03056E http://dx.doi.org/10.1039/C9SC03056E

Sha Y. ; Zhou Z. ; Zhang J. L. ; Chen X. F. ; Luo Z. Y. ; Li X. Heterobimetallic block copolymers with a combined main-chain/side-chain topology . Chem. Commun. , 2023 , 59 ( 2 ), 207 - 210 . doi: 10.1039/d2cc05990h http://dx.doi.org/10.1039/d2cc05990h

Jordan J. ; Grubbs R. Small-molecule N -heterocyclic-carbene-containing olefin-metathesis catalysts for use in water . Angew. Chem. Int. Ed. , 2007 , 46 ( 27 ), 5152 - 5155 . doi: 10.1002/anie.200701258 http://dx.doi.org/10.1002/anie.200701258

Isarov, S. A.; Pokorski, J. K. Protein ROMP: aqueous graft-from ring-opening metathesis polymerization . ACS Macro Lett. , 2015 , 4 ( 9 ), 96 - 973 . doi: 10.1021/acsmacrolett.5b00497 http://dx.doi.org/10.1021/acsmacrolett.5b00497

Wright D. B. ; Touve M. A. ; Thompson M. P. ; Gianneschi N. C. Aqueous-phase ring-opening metathesis polymerization-induced self-assembly . ACS Macro Lett. , 2018 , 7 ( 4 ), 401 - 405 . doi: 10.1021/acsmacrolett.8b00091 http://dx.doi.org/10.1021/acsmacrolett.8b00091

Wright D. B. ; Thompson M. P. ; Touve M. A. ; Carlini A. S. ; Gianneschi N. C. Enzyme-responsive polymer nanoparticles via ring-opening metathesis polymerization-induced self-assembly . Macromol. Rapid Commun. , 2019 , 40 ( 2 ), 1970004 . doi: 10.1002/marc.201800467 http://dx.doi.org/10.1002/marc.201800467

Wright D. B. ; Proetto M. T. ; Touve M. A. ; Gianneschi N. C. Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) of a cisplatin analogue for high drug-loaded nanoparticles . Polym. Chem. , 2019 , 10 ( 23 ), 2996 - 3000 . doi: 10.1039/c8py01539b http://dx.doi.org/10.1039/c8py01539b

Torres-Rocha O. L. ; Wu X. W. ; Zhu C. Y. ; Crudden C. M. ; Cunningham M. F. Polymerization-induced self-assembly (PISA) of 1 , 5 -cyclooctadiene using ring-opening metathesis polymerization . Macromol. Rapid Commun., 2019, 40 ( 2 ), 1800326 . doi: 10.1002/marc.201800326 http://dx.doi.org/10.1002/marc.201800326

Church D. C. ; Takiguchi L. ; Pokorski J. K. Optimization of ring-opening metathesis polymerization (ROMP) under physiologically relevant conditions . Polym. Chem. , 2020 , 11 ( 27 ), 4492 - 4499 . doi: 10.1039/d0py00716a http://dx.doi.org/10.1039/d0py00716a

Dunbar M. ; Balof S. ; LaBeaud L. ; Yu B. ; Lowe A. ; Valente E. ; Schanz H. J. Improved molecular weight control in ring-opening metathesis polymerization (ROMP) reactions with Ru-based olefin metathesis catalysts using N donors and acid: a kinetic and mechanistic investigation . Chem. , 2009 , 15 ( 45 ), 12435 - 12446 . doi: 10.1002/chem.200901013 http://dx.doi.org/10.1002/chem.200901013

Foster J. C. ; Varlas S. ; Blackman L. D. ; Arkinstall L. A. ; O'Reilly R. K. Ring-opening metathesis polymerization in aqueous media using a macroinitiator approach . Angew. Chem. Int. Ed. , 2018 , 57 ( 33 ), 10672 - 10676 . doi: 10.1002/anie.201806719 http://dx.doi.org/10.1002/anie.201806719

Varlas S. ; Foster J. C. ; O'Reilly R. K. Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) . Chem. Commun. , 2019 , 55 ( 62 ), 9066 - 9071 . doi: 10.1039/c9cc04445k http://dx.doi.org/10.1039/c9cc04445k

Varlas S. ; Foster J. C. ; Arkinstall L. A. ; Jones J. R. ; Keogh R. ; Mathers R. T. ; O'Reilly R. K. Predicting monomers for use in aqueous ring-opening metathesis polymerization-induced self-assembly . ACS Macro Lett. , 2019 , 8 ( 4 ), 466 - 472 . doi: 10.1021/acsmacrolett.9b00117 http://dx.doi.org/10.1021/acsmacrolett.9b00117

Varlas S. ; Keogh R. ; Xie Y. J. ; Horswell S. L. ; Foster J. C. ; O'Reilly R. K. Polymerization-induced polymersome fusion . J. Am. Chem. Soc. , 2019 , 141 ( 51 ), 20234 - 20248 . doi: 10.1021/jacs.9b10152 http://dx.doi.org/10.1021/jacs.9b10152

Views

565

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Stimuli Responsive Nano-objects via Polymerization Induced Self-assembly

Synthesis and Investigation on Molecular Conformation of Amphiphilic Dendronized Brush Block Copolymer

Preparation of Enteromorpha prolifera Cellulose-based Foldable Evaporator and Its Desalination Performance

Research Progress on the Synthesis and Application of Metal-Organic Framework-based Polymeric Antibacterial Materials

Copolymerization of Carbon Dioxide and Propylene Oxide Catalyzed by Tri-centered Aluminum Porphyrin Complexes

Related Author

Ting-ting Xu

Mu-zhou Li

Xin Hu

Ning Zhu

Hao-wei Zhang

Wen-jian Han

Yi-huan Liu

Ning Zhu

Related Institution

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University

College of Materials Science and Engineering, Nanjing Tech University

College of Biotechnology and Pharmaceutical Engineering

State Key Laboratory of Materials-Oriented Chemical Engineering

School of Materials Science and Engineering, Tianjin University

AI问答

Postal code：100190
Tel：010-62588927 Email：gfzxb@iccas.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05002797号-8 京公网安备11010802046899号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰