A Polydimethylsiloxane Membrane-regulated Oxygen-generating System Based on Multi-interface Reaction-Transport Coupling for Chronic Wound Therapy

Wei Huang; Ming-yu Chen; Jing Zang; Hong-jie Gao; Zong-huan Ba; Wen-qian Liu; Ye-zi You; Long-hai Wang

doi:10.11777/j.issn1000-3304.2026.26118

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A Polydimethylsiloxane Membrane-regulated Oxygen-generating System Based on Multi-interface Reaction-Transport Coupling for Chronic Wound Therapy

更新时间：2026-07-10

- A Polydimethylsiloxane Membrane-regulated Oxygen-generating System Based on Multi-interface Reaction-Transport Coupling for Chronic Wound Therapy
- Acta Polymerica Sinica Pages: 1-14(2026)
- 作者机构：
  
  1.中国科学技术大学精准智能化学全国重点实验室合肥 230026
  2.中国科学技术大学高分子科学与工程系合肥 230026
  3.中国科学技术大学附属第一医院合肥 230026
- 作者简介：
  
  Long-hai Wang, E-mail: hiwang@ustc.edu.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2026.26118
  CLC：
- CSTR：32057.14.GFZXB.2026.7620
- Received：13 April 2026，
  
  Accepted：08 May 2026，
  
  Online First：10 July 2026，
- 稿件说明：
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黄伟, 陈明宇, 臧晶, 高洪杰, 把宗桓, 刘文骞, 尤业字, 王龙海. 聚二甲基硅氧烷膜调控的多界面反应-传质耦合产氧体系及其在慢性创面中的应用. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26118.

Huang, W.; Chen, M. Y.; Zang, J.; Gao, H. J.; Ba, Z. H.; Liu, W. Q.; You, Y. Z.; Wang, L. H. A polydimethylsiloxane membrane-regulated oxygen-generating system based on multi-interface reaction-transport coupling for chronic wound therapy. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26118.
黄伟, 陈明宇, 臧晶, 高洪杰, 把宗桓, 刘文骞, 尤业字, 王龙海. 聚二甲基硅氧烷膜调控的多界面反应-传质耦合产氧体系及其在慢性创面中的应用. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26118. DOI： CSTR： 32057.14.GFZXB.2026.7620.

Huang, W.; Chen, M. Y.; Zang, J.; Gao, H. J.; Ba, Z. H.; Liu, W. Q.; You, Y. Z.; Wang, L. H. A polydimethylsiloxane membrane-regulated oxygen-generating system based on multi-interface reaction-transport coupling for chronic wound therapy. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26118. DOI： CSTR： 32057.14.GFZXB.2026.7620.

摘要

慢性创面愈合过程中持续缺氧是限制组织再生的关键因素，开发可控供氧的高分子材料体系具有重要意义. 本研究构建了一种基于聚二甲基硅氧烷(PDMS)膜与海藻酸钠水凝胶多界面调控的反应-传质耦合产氧体系. 该体系通过多层结构设计，在空间上构建过氧化氢(H

)储存、跨膜扩散、界面催化及氧气传输的分级路径，实现对反应与传质行为的协同调控. 其中，PDMS膜作为关键传质调控界面，通过调节膜厚实现H

通量的精确控制，将其快速分解过程转化为受传质调控的稳定反应；催化层提供固-气界面反应环境；水凝胶界面则介导氧气由气态向溶解态转化，并促进其向创面组织扩散. 实验结果表明，该体系能够实现持续稳定的溶解氧输出，并显著提高低氧条件下细胞存活率. 在糖尿病创面模型中，该体系显著促进创面愈合，并增强胶原沉积及血管生成. 本研究揭示了多界面协同调控反应与传质过程的材料设计策略，为缺氧相关疾病的高分子功能材料设计提供了新思路.

Abstract

Persistent hypoxia is a critical factor limiting tissue regeneration during chronic wound healing

highlighting the importance of developing polymer-based systems capable of controlled oxygen delivery. In this work

we constructed a reaction-transport coupled oxygen-generating system based on multi-interface regulation by a polydimethylsiloxane (PDMS) membrane and an alginate hydrogel. Through a multilayer structural design

the system spatially integrated hydrogen peroxide (H

) storage

transmembrane diffusion

interfacial catalysis

and oxygen transport into a hierarchical pathway

enabling coordinated control over reaction and mass transport processes. The PDMS membrane served as a key transport-regulating interface

where membrane thickness governs the flux of H

converting its intrinsically rapid decomposition into a diffusion-controlled and stabilized reaction process. The MnO

catalytic layer provided a solid-gas interfacial reaction environment

while the hydrogel interface facilitated the conversion of oxygen from gaseous to dissolved form and promotes its transport into surrounding tissue. Experimental results demonstrated that the system enabled sustained and stable dissolved oxygen output

significantly improving cell viability under hypoxic conditions. In a diabetic wound model

the system markedly accelerated wound healing

accompanied by enhanced collagen deposition and neovascularization. This work reveals a materials design strategy based on multi-interface coordination of reaction and transport processes

providing new insights into the development of functional polymer systems for hypoxia-related diseases.

关键词

Keywords

references

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