Enzymatic Ring-opening Polymerizations of Cyclic Carbonates

Yu Zhang; Xin-Yu Jiang; Xin Hu; Ning Zhu

doi:10.11777/j.issn1000-3304.2026.26161

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Enzymatic Ring-opening Polymerizations of Cyclic Carbonates

更新时间：2026-07-22

- Enzymatic Ring-opening Polymerizations of Cyclic Carbonates
- Acta Polymerica Sinica Pages: 1-25(2026)
- 作者机构：
  
  1.南京工业大学生物与制药工程学院南京 211800
  2.南京工业大学材料化学工程全国重点实验室南京 211800
  3.南京工业大学材料科学与工程学院南京 211800
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2026.26161
  CLC：
- CSTR：32057.14.GFZXB.2026.7664
- Received：08 May 2026，
  
  Accepted：09 June 2026，
  
  Online First：21 July 2026，
- 稿件说明：
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张雨, 姜鑫宇, 胡欣, 朱宁. 酶促环碳酸酯开环聚合. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26161.

Zhang, Y.; Jiang, X. Y.; Hu, X; Zhu, N. Enzymatic ring-opening polymerizations of cyclic carbonates. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26161.
张雨, 姜鑫宇, 胡欣, 朱宁. 酶促环碳酸酯开环聚合. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26161. DOI： CSTR： 32057.14.GFZXB.2026.7664.

Zhang, Y.; Jiang, X. Y.; Hu, X; Zhu, N. Enzymatic ring-opening polymerizations of cyclic carbonates. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26161. DOI： CSTR： 32057.14.GFZXB.2026.7664.

摘要

酶促环状单体开环聚合(ROP)是制备生物降解聚合物的绿色合成途径. 脂肪族聚碳酸酯展现出良好的生物相容性、生物降解性和结构可设计性，已成为组织工程、药物递送、电子材料和包装材料等领域的研究热点. 近年来，以酶为催化剂、醇为引发剂，通过开环聚合制备了一系列不同结构的功能化生物降解聚碳酸酯. 本综述以三亚甲基碳酸酯、三亚甲基碳酸酯衍生物、四亚甲基碳酸酯、大环碳酸酯单体分类，总结了酶促环碳酸酯开环聚合的研究进展、机遇与挑战，希望对生物合成高分子和生物降解材料等相关领域提供借鉴.

Abstract

Enzymatic ring-opening polymerization (ROP) of cyclic monomers has emerged as a green and sustainable method for synthesizing biodegradable polymers. Among these materials

aliphatic polycarbonates have attracted considerable attention owing to their excellent biocompatibility

biodegradability

and diverse structures

with broad applications in tissue engineering

drug delivery

electronic materials

and packaging. Recently

a variety of functionalized biodegradable polycarbonates have been synthesized through the enzymatic ROP of cyclic carbonates in the presence of alcohol initiators. This review highlights the advances

challenges

and opportunities in the biocatalytic ROP of trimethylene carbonate (TMC)

TMC derivatives

tetramethylene carbonate

and macrocyclic carbonates as monomers. This study provides guidance for the development of biosynthesis of polymers and biodegradable polymers.

关键词

Keywords

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