Dynamic Polymer Materials Based on Knoevenagel Condensation Reaction

Rui-zhu Yang; Xiao-ya Ding; Yao-wei Zhu; Xiao-nong Zhang; Yan-long Liu; Chun-sheng Xiao; Xue-si Chen

doi:10.11777/j.issn1000-3304.2026.26220

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Dynamic Polymer Materials Based on Knoevenagel Condensation Reaction

更新时间：2026-08-07

- Dynamic Polymer Materials Based on Knoevenagel Condensation Reaction
- Acta Polymerica Sinica Pages: 1-19(2026)
- 作者机构：
  
  1.中国科学院长春应用化学研究所高分子与技术全国重点实验室长春 130022
  2.安徽医科大学第一附属医院肿瘤免疫医药基础研究创新中心合肥 230022
  3.泰山学院化学化工学院泰安 271000
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2026.26220
  CLC：
- CSTR：32057.14.GFZXB.2026.7713
- Received：22 June 2026，
  
  Accepted：31 July 2026，
  
  Online First：06 August 2026，
- 稿件说明：
移动端阅览
杨蕊竹, 丁晓亚, 朱耀威, 张箫浓, 刘焱龙, 肖春生, 陈学思. 基于Knoevenagel缩合反应的动态高分子材料. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26220.

Yang, R. Z.; Ding, X. Y.; Zhu, Y. W.; Zhang, X. N.; Liu, Y. L.; Xiao, C. S.; Chen, X. S. Dynamic polymer materials based on Knoevenagel condensation reaction. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26220.
杨蕊竹, 丁晓亚, 朱耀威, 张箫浓, 刘焱龙, 肖春生, 陈学思. 基于Knoevenagel缩合反应的动态高分子材料. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26220. DOI： CSTR： 32057.14.GFZXB.2026.7713.

Yang, R. Z.; Ding, X. Y.; Zhu, Y. W.; Zhang, X. N.; Liu, Y. L.; Xiao, C. S.; Chen, X. S. Dynamic polymer materials based on Knoevenagel condensation reaction. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26220. DOI： CSTR： 32057.14.GFZXB.2026.7713.

摘要

Knoevenagel缩合反应是醛或者酮与含有活泼亚甲基的化合物反应形成C＝C的经典反应，已被广泛应用于合成精细化学品、天然产物、染料和高分子材料等. 该反应不仅能够在有机溶剂中顺利进行，在水溶液中亦能在有或无催化剂条件下高效发生. 基于其温和高效的特点，近年来研究者尝试将其应用于新型高分子材料的构建. 研究发现，该反应生成的C＝C在水相和有机相中均表现出显著的动态性，这一特性使其既能用于制备可注射、自愈合的动态水凝胶，也能用于构建动态类玻璃高分子材料(Vitrimer)，已然成为动态高分子合成领域的一种新兴化学工具. 本综述主要就近些年来基于Knoevenagel缩合反应的动态高分子材料的设计和构建策略，及其在生物医学、可回收材料和生物基绿色材料等领域的应用与进展进行总结，并对该研究目前存在的挑战和应用潜力进行展望.

Abstract

The Knoevenagel condensation of aldehydes or ketones with active methylene compounds represents a classic method for carbon-carbon double bond formation in organic synthesis and has wide applications in the synthesis of fine chemicals

natural products

dyes

and polymeric materials. Notably

this reaction proceeds efficiently not only in conventional organic solvents but also in aqueous media in the presence or absence of catalysts. Benefiting from the mild and efficient characteristics

this reaction has recently been explored as a powerful platform for constructing novel polymeric materials. Emerging evidence indicates that the resultant C＝C bonds exhibit significant dynamic behavior in both aqueous and organic phases

enabling their application in the fabrication of injectable and self-healing dynamic hydrogels as well as dynamic vitrimers. Consequently

the Knoevenagel condensation has emerged as a promising chemical tool in the field of dynamic polymer synthesis. In this review

we systematically summarized recent advances in the design and construction strategies of dynamic polymeric materials based on the Knoevenagel condensation

with a particular focus on their applications in biomedicine

recyclable materials

and biomass-derived green materials. Moreover

the current challenges and future application potential of this kind of materials were also discussed and prospected.

关键词

Keywords

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