SYNTHESIS OF THERMO- AND pH SENSITIVE POLYMER BEADS CONTAINING β-CYCLODEXTRIN AND POLY(N, N-DIMETHYLAMINOETHYL METHACRYLATE AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR

HU Hui; LIU Yuyang; FAN Xiaodong; HUANG Yi

doi:null

您当前的位置：

首页 >

文章列表页 >

SYNTHESIS OF THERMO- AND pH SENSITIVE POLYMER BEADS CONTAINING β-CYCLODEXTRIN AND POLY(N, N-DIMETHYLAMINOETHYL METHACRYLATE AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR

Research Article | 更新时间：2021-03-19

- SYNTHESIS OF THERMO- AND pH SENSITIVE POLYMER BEADS CONTAINING β-CYCLODEXTRIN AND POLY(N, N-DIMETHYLAMINOETHYL METHACRYLATE AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR
- Acta Polymerica Sinica Issue 3, Pages: 357-362(2005)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：20 June 2005，
扫描看全文
HU Hui, LIU Yuyang, FAN Xiaodong, HUANG Yi. SYNTHESIS OF THERMO- AND pH SENSITIVE POLYMER BEADS CONTAINING β-CYCLODEXTRIN AND POLY(N, N-DIMETHYLAMINOETHYL METHACRYLATE AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR. [J]. Acta Polymerica Sinica (3):357-362(2005)
DOI：

HU Hui, LIU Yuyang, FAN Xiaodong, HUANG Yi. SYNTHESIS OF THERMO- AND pH SENSITIVE POLYMER BEADS CONTAINING β-CYCLODEXTRIN AND POLY(N, N-DIMETHYLAMINOETHYL METHACRYLATE AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR. [J]. Acta Polymerica Sinica (3):357-362(2005) DOI：

摘要

以反相乳液聚合得到了β-CD聚合物微球

对β-CD微球进行氯乙酰化改性后

利用原子转移自由基聚合的方法把聚甲基丙烯酸N

N 二甲氨基乙酯(PDMAEMA)接枝到β-CD微球上

从而得到了具有温度和pH响应性的β- CD聚合物微球.通过红外光谱、元素分析确定了PDMAEMA接枝的β- CD微球的结构

采用热台偏光显微镜直接观测到了β-CD微球的温度和pH敏感性.对模型药物染料木素(GNT)和苯丁酸氮芥(CLB )进行了控制释放研究

结果表明pH值可对微球的“内环境”起到“开关”作用

从而可构筑出一种新型的药物控制释放体系.

Abstract

Polymer beads containing β-cycledextrin(β-CD) were prepared by inverse emulsion polymerization

and then

the polymer beads with thermo- and pH sensitivities were synthesized by atom transfer radical polymerization (ATRP) using N

N-dimethylaminoethyl methacrylate (DMAEMA) as a functional monomer and anterior chloroacetylated β-CD as the initiator．Chain structure and their compositions for polymers grafting with poly(N

N-dimethylaminoethyl methacrylate)(PDMAEMA) were characterized using infrared spectroscopy

element analysis

DSC and TGA The thermo- and pH sensitivities for polymers containing β-eyclodextrin and PDMAEMA were inspected directly with a polarizing microscope equipping with a hot stage Finally

the controHed drug release behaviors of these polymersweYe studied using anti-cancer drugs

genistein (GNT) and chlorambucil (CLB) as model compounds Results show that the release efficiency for drugs depends on the pH value which can act as an“on-off”switch during the test It was indicated that a controlled drug delivery system could be established according to these experimental data．

关键词

β-环糊精聚合物微球聚甲基丙烯酸NN-二甲氨基乙酯温度及pH敏感性药物控制释放体系

Keywords

references

更多指标>

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

SYNTHESIS AND CHARACTERIZATION OF THE THERMO-AND pH-SENSITIVE DENTRITIC POLYMERS BASED ON POLYAMIDOAMINE DENDRIMER AND POLY(N,N-DIMETHYLAMINOETHYL METHACRYLATE) AND STUDY ON THEIR CONTROLLED DRUG RELEASE BEHAVIOR

SYNTHESIS AND CHARACTERIZATION OF THE THERMO- AND pH SENSITIVE STAR POLYMERS WITH A RIGID CORE OF β-CYCLODEXTRIN

MECHANISTIC STUDY OF CATALYTIC OXIDATIVE COPOLYMERIZATION OF 2-(N,N-DIMETHYLAMINO)ETHYL METHACRYLATE AND METHYL METHACRYLATE

DEVELOPMENT OF BRANCHING STRUCTRUE IN SELF-CONDENSING ATOM TRANSFER RADICAL COPOLYMERIZATION WITH A LARGE COMONOMER/INIMER FEED RATIO

SYNTHESIS OF POLYBUTADIENE-b-POLY［2-(DIMETHYLAMINO)ETHYL METHACRYLATE］ AMPHIPHILIC BLOCK COPOLYMER BY MECHANISM TRANSFORMATION

Related Author

No data

Related Institution

No data

Postal code：100190
Tel：010-62588927 Email：gfzxb@iccas.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05002797号-8 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰