SYNTHESIS AND CHARACTERIZATION OF NOVEL COPOLYMERS CONTAINING PENDANT AMINE FUNCTIONAL GROUPS BASED ON D,L-LACTIDE, GLYCOLIDE AND POLY(PEG-co-L-ASPARTIC ACID)

LUO Binghong; QUAN Daping; LIAO Kairong; LU Zejian; ZHOU Changren

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SYNTHESIS AND CHARACTERIZATION OF NOVEL COPOLYMERS CONTAINING PENDANT AMINE FUNCTIONAL GROUPS BASED ON D,L-LACTIDE, GLYCOLIDE AND POLY(PEG-co-L-ASPARTIC ACID)

Research Article | 更新时间：2021-03-19

- SYNTHESIS AND CHARACTERIZATION OF NOVEL COPOLYMERS CONTAINING PENDANT AMINE FUNCTIONAL GROUPS BASED ON D,L-LACTIDE, GLYCOLIDE AND POLY(PEG-co-L-ASPARTIC ACID)
- Acta Polymerica Sinica Issue 3, Pages: 327-332(2005)
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- Published：20 June 2005，
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LUO Binghong, QUAN Daping, LIAO Kairong, LU Zejian, ZHOU Changren. SYNTHESIS AND CHARACTERIZATION OF NOVEL COPOLYMERS CONTAINING PENDANT AMINE FUNCTIONAL GROUPS BASED ON D,L-LACTIDE, GLYCOLIDE AND POLY(PEG-co-L-ASPARTIC ACID). [J]. Acta Polymerica Sinica (3):327-332(2005)
DOI：

LUO Binghong, QUAN Daping, LIAO Kairong, LU Zejian, ZHOU Changren. SYNTHESIS AND CHARACTERIZATION OF NOVEL COPOLYMERS CONTAINING PENDANT AMINE FUNCTIONAL GROUPS BASED ON D,L-LACTIDE, GLYCOLIDE AND POLY(PEG-co-L-ASPARTIC ACID). [J]. Acta Polymerica Sinica (3):327-332(2005) DOI：

摘要

以聚乙二醇(PEG)和N-苄氧羰基-L-天冬氨酸酐为原料

通过溶液缩聚法制备了聚(聚乙二醇-co-L-天冬氨酸)交替预聚物(PEG-ASP)n;进一步以辛酸亚锡为催化剂、(PEG-ASP)n 为共引发剂引发D

L-LA和GA开环共聚合成了带有侧氨基功能基团的PLGA (PEG-ASP)n 共聚物.用GPC、FT-IR、1H-NMR、DSC等研究了共聚物的结构和性能.结果表明

共聚物表现为典型的无定形聚合物;(PEG-ASP)n 的含量对共聚物的性能有显著影响

随(PEG-ASP)n 含量增加

共聚物的亲水性增强

玻璃化转变温度(Tg)下降;以Pd(5wt%)C为催化剂

采用催化加氢方法可完全脱除共聚物侧氨基上的保护基团;脱除侧氨基上的保护基团后

共聚物的分子量和Tg 值均略有增大

亲水性有所提高.

Abstract

Poly(poly(ethylene glycol)-co-L-aspartic acid) (PEG-ASP)n ahemating prepolymer was first prepared by the solution polycondensation from N-(benzyloxycarbonyl)-L-aspartic acid anhydride and poly(ethylene glycol)．Then

the novel PLGA-(PEG-ASP)n copolymers with pendant amine functional groups were synthesized by bulk ring-opening eopolymerization of D

L-LA with GA using tin octoate(Sn(Oct)2) as a catalyst

and (PEG-ASP)n prepolymer as a co-initiator．The structure and properties of the novel eopolymers were studied by GPC

FT-IR

1H-NMR and DSC

etc．Results showed that the PLGA-(PEG-ASP)n copolymers were typical amorphous polymers．The content of (PEG-ASP)n prepolymer had significant influence on the properties of the copolymers．The hydmphilieity of the eopolymers was improved and the value of the glass transition temperature(Tg) decreased as the content of the prepolymer increased．The benzyloxyearbonyl (CBz) protecting groups of the eopolymer were totally removed by catalytic transfer hydrogenation using palladium over activated carbon(5 wt％) as a catalyst and H2 as an effective hydrogen donor．The molecular welight

the value of Tg and hydrophilieity of the eopolymer were somewhat increased as the CBz protecting groups were removed．

关键词

组织工程聚（DL-丙交酯-co-乙交酯）聚（聚乙二醇-co-L-天冬氨酸）功能化

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