STUDY ON A COMB-LIKE COPOLYMER DERIVED FROM DEXTRAN AND L-LACTIDE:SYNTHESIS AND DEGRADATION

CAI Qing; BEI Jianzhong; WANG Shenguo

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STUDY ON A COMB-LIKE COPOLYMER DERIVED FROM DEXTRAN AND L-LACTIDE:SYNTHESIS AND DEGRADATION

Research Article | 更新时间：2021-03-19

- STUDY ON A COMB-LIKE COPOLYMER DERIVED FROM DEXTRAN AND L-LACTIDE:SYNTHESIS AND DEGRADATION
- Acta Polymerica Sinica Issue 5, Pages: 719-725(2004)
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- Published：20 October 2004，
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CAI Qing, BEI Jianzhong, WANG Shenguo. STUDY ON A COMB-LIKE COPOLYMER DERIVED FROM DEXTRAN AND L-LACTIDE:SYNTHESIS AND DEGRADATION. [J]. Acta Polymerica Sinica (5):719-725(2004)
DOI：

CAI Qing, BEI Jianzhong, WANG Shenguo. STUDY ON A COMB-LIKE COPOLYMER DERIVED FROM DEXTRAN AND L-LACTIDE:SYNTHESIS AND DEGRADATION. [J]. Acta Polymerica Sinica (5):719-725(2004) DOI：

摘要

研究了聚乳酸接枝葡聚糖梳型共聚物的合成

以及共聚物的结构特征、亲水性能及降解行为的表征 .结果表明由于亲水性葡萄糖单元组分的引入以及共聚物的梳型结构特征

聚乳酸接枝葡聚糖共聚物的亲水性明显优于相应的线型聚乳酸

而且降解速度也明显加快 .由于这类梳型结构的聚多糖聚酯共聚物综合了聚多糖细胞亲和性好和聚酯生物降解速率可调节性的特点

因此有望成为一类优良的细胞支架材料 .

Abstract

Comb-like biodegradable polylactide-grafted dextran copolymer (Dextran-g-PLA) was synthesized in a bulk lactide polymerization reaction using dextran derivative as macroinitiator and stannous octoate as catalyst．The Dextran-g-PLA copolymers were characterized by 1H-NMR

GPC and intrinsic viscosity measurements

and their molecular architecture was confirmed as PLA segments attached to dextran backbones．Compared to pure PLA

the copolymers showed higher hydrophilicity and faster degradation rate due to the incorporation of hydrophilic glucose units and comb-like structure

which resulted in shortened PLA chain length. This Dextran-g-PLA copolymer was envisioned having good cell affinity and being a good candidate as cell scaffold materials for tissue engineering applications．

关键词

生物可降解葡聚糖聚乳酸梳型组织工程

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Related Institution

School of Material Science and Engineering, Wuhan Institute of Technology

Center for PET of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Key laboratory of Auxiliary Chemistry and Technology for Chemical Industry of Ministry of Education, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology

扬州大学化学化工学院

扬州大学江苏省环境工程与环境材料重点实验室

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