DEGRADATION in-vitro AND CELL AFFINITY OF POLY(L-LACTIDE-co-β-MALIC ACID)

HE Bin; WAN Yuqing; BEI Jianzhong; WANG Shenguo

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DEGRADATION in-vitro AND CELL AFFINITY OF POLY(L-LACTIDE-co-β-MALIC ACID)

Research Article | 更新时间：2021-03-19

- DEGRADATION in-vitro AND CELL AFFINITY OF POLY(L-LACTIDE-co-β-MALIC ACID)
- Acta Polymerica Sinica Issue 5, Pages: 693-699(2004)
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- Published：20 October 2004，
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HE Bin, WAN Yuqing, BEI Jianzhong, WANG Shenguo. DEGRADATION in-vitro AND CELL AFFINITY OF POLY(L-LACTIDE-co-β-MALIC ACID). [J]. Acta Polymerica Sinica (5):693-699(2004)
DOI：

HE Bin, WAN Yuqing, BEI Jianzhong, WANG Shenguo. DEGRADATION in-vitro AND CELL AFFINITY OF POLY(L-LACTIDE-co-β-MALIC ACID). [J]. Acta Polymerica Sinica (5):693-699(2004) DOI：

摘要

研究了具有功能侧基的新型生物降解高分子——[聚 (L-丙交酯-co-β 苹果酸)](PLMA)在pH 7.4的磷酸缓冲溶液中的降解和鼠的3T3成纤维细胞在共聚物膜表面的贴附及生长 .研究了不同组成的共聚物在降解过程中的失重、表面形貌、组成及分子量变化

发现PLMA为本体降解

共聚物中苹果酸含量的提高可以加速降解

降解过程中聚苹果酸 (PMA)链段附近的酯键先水解断裂 .鼠的3T3成纤维细胞在聚L-丙交酯 (PLLA)均聚物和苹果酸含量为4mol%

8mol%和13mol%的共聚物膜上培养5h

细胞贴附率分别为43%、71%、80 %和 43% .3T3成纤维细胞在苹果酸含量为 4mol%和 8mol%的共聚物膜上的生长情况好于在PLLA均聚物和苹果酸含量为 13mol%含量的共聚物膜上的生长.

Abstract

The degradation behavior of a novel functionalized biodegradable poly(L-lactide-co-β- malic acid) in pH 7.4 PBS was studied

and mice 3T3 fibroblasts were cultivated on copolymer films to evaluate the cell affinity of copolymers．The variation of weight loss

surface morphology

composition and molecular weight of copolymers were investigated. The results showed that the degradation of poly(L-lactide-co-β-malic acid) was bulk degradation

the malic acid could accelerate the degradation rate

the ester bonds near PMA segments hydrolyzed prior to the ester bonds in PLLA．The cell attachment rate of 3T3 fibroblasts on the surface of PLLA

PLMA96／4

PLMA92／8 and PLMA87／13 was 43％

71％

80％ and 43％

respectively when cultivated for 5 h

the morphology of 3T3 fibroblast was berter on the surface of PLMA96/4 and PLMA92／8 than that on the surface of PLLA and PLMA87／13 when cultivated for 24 h.

关键词

聚（L-丙交酯-co-β-苹果酸）生物降解细胞贴附

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