THE SYNTHESIS OF CARBOXYMETHYLCHITOSAN HYDROGEL AND THE APPLICATION IN DRUG CONTROLLED RELEASE SYSTEMS

SUN Liping; DU Yumin; CHEN Lingyun; HUANG Ronghua; CHEN Xiao

doi:null

您当前的位置：

首页 >

文章列表页 >

THE SYNTHESIS OF CARBOXYMETHYLCHITOSAN HYDROGEL AND THE APPLICATION IN DRUG CONTROLLED RELEASE SYSTEMS

Research Article | 更新时间：2021-03-19

- THE SYNTHESIS OF CARBOXYMETHYLCHITOSAN HYDROGEL AND THE APPLICATION IN DRUG CONTROLLED RELEASE SYSTEMS
- Acta Polymerica Sinica Issue 2, Pages: 191-195(2004)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：20 April 2004，
扫描看全文
SUN Liping, DU Yumin, CHEN Lingyun, HUANG Ronghua, CHEN Xiao. THE SYNTHESIS OF CARBOXYMETHYLCHITOSAN HYDROGEL AND THE APPLICATION IN DRUG CONTROLLED RELEASE SYSTEMS. [J]. Acta Polymerica Sinica (2):191-195(2004)
DOI：

SUN Liping, DU Yumin, CHEN Lingyun, HUANG Ronghua, CHEN Xiao. THE SYNTHESIS OF CARBOXYMETHYLCHITOSAN HYDROGEL AND THE APPLICATION IN DRUG CONTROLLED RELEASE SYSTEMS. [J]. Acta Polymerica Sinica (2):191-195(2004) DOI：

摘要

以戊二醛为交联剂制备了一系列羧甲基壳聚糖pH敏感水凝胶 .研究了合成条件对羧甲基壳聚糖水凝胶溶胀性能的影响 .实验结果表明羧甲基壳聚糖的脱乙酰度、交联剂用量对水凝胶溶胀率的影响较大 .pH=3.0时

水凝胶收缩

而pH =1.0

5.0

7.4

9.0时

水凝胶溶胀

且在碱性条件下水凝胶的溶胀率远大于酸性条件下的溶胀率 .包埋在此水凝胶中的水杨酸释放随载药介质的pH值和水凝胶半径大小的变化而显著不同

pH =1.0条件下载药的水凝胶的释药率大于pH =7.4

12.0条件下的释药率

且水凝胶的半径越大

释药速度和释药率也越大.

Abstract

pH-sensitive hydrogels based on carboxymethylchitosan (CMCTS) were synthesized by using glutaraldehyde as cross-link agenl The effects of the degree of deacetylation of CMCTS and the dosage of erosslinker on the swelling behaviors of hydrogels have been studied The results show that the two factors related above regulate their swelling behavior At pH=3.0

the hydmgel shfinked most while swelled at pH：1 0

5．0

7．4

9 0．In general

the swelling ratio (SR) of this hydrogel in alkaline solution is much larger than that in acidic solution．The release behavior of salicylic acid(SA)entrapped in the hydrogels was of distinctly difference with the changes of pH value of loading medium and the semidiameter of the hydrogels．The release of salicylic acid in CMCT hydmgel in the medium of pH=1.0 was much quickerin pH=7.4

12.0

andtherelease speed and release ratioincrease with the partical size．

关键词

羧甲基壳聚糖水凝胶溶胀率水杨酸控制释放

Keywords

references

更多指标>

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

CONTROLLED RELEASE OF SALICYLIC ACID FROM ELECTROSPUN MATS OF POLY(-CAPROLACTONE) WITH LOW CRYSTALLINITY

PREPATION OF SALICYLIC ACIDFUNCTIONALIZED POLYSTYRENE AND PRELIMINARY EXPLORATION OF FLUORESCENCE CHARACTER OF ITS COMPLEX WITH Eu (Ⅲ)

SYNTHESIS OF HYDROPHOBIC-HYDROPHILIC MACROPOROUS POLYDIVINYLBENZENE/POLY(N-2-AMINOETHYLACRYLAMIDE) IPN RESIN AND ITS ADSORPTION PERFORMANCES FOR SALICYLIC ACID IN AQUEOUS SOLUTIONS

STUDIES ON THE MICRO/NANO-STRUCTURED POLYANILINE AND ITS WETTABILITY

SWELLING BEHAVIOR OF(E-CE)C/CROSS-LINKED PAA COMPOSITES

Related Author

No data

Related Institution

No data

Postal code：100190
Tel：010-62588927 Email：gfzxb@iccas.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05002797号-8 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰