PREPARATION AND PROPERTIES OF A THERMO-SENSITIVE HYDROGEL BASED ON OXIDIZED SODIUM ALGINATE

WU Nianqiang; PAN Chunyue; ZHANG Baojin; RAO Yanping; YU Dian

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PREPARATION AND PROPERTIES OF A THERMO-SENSITIVE HYDROGEL BASED ON OXIDIZED SODIUM ALGINATE

Research Article | 更新时间：2021-03-19

- PREPARATION AND PROPERTIES OF A THERMO-SENSITIVE HYDROGEL BASED ON OXIDIZED SODIUM ALGINATE
- Acta Polymerica Sinica Issue 6, Pages: 497-502(2007)
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- Published：20 June 2007，
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WU Nianqiang, PAN Chunyue, ZHANG Baojin, RAO Yanping, YU Dian. PREPARATION AND PROPERTIES OF A THERMO-SENSITIVE HYDROGEL BASED ON OXIDIZED SODIUM ALGINATE. [J]. Acta Polymerica Sinica (6):497-502(2007)
DOI：

WU Nianqiang, PAN Chunyue, ZHANG Baojin, RAO Yanping, YU Dian. PREPARATION AND PROPERTIES OF A THERMO-SENSITIVE HYDROGEL BASED ON OXIDIZED SODIUM ALGINATE. [J]. Acta Polymerica Sinica (6):497-502(2007) DOI：

摘要

合成出一种具有温敏特性的多官能团的大分子聚（N-异丙基丙烯酰胺-丙烯酸甲酯-丙烯酰肼）（PNMH）

用它交联氧化的海藻酸钠（OSA）

得到可生物降解的温敏凝胶PNMH-OSA.分别以凝胶的透光率随温度变化和凝胶在磷酸盐缓冲液（PBS）中的溶胀比随时间变化来考察凝胶的温敏性能和降解性能

并采用傅立叶变换红外光谱（FTIR）和激光共焦拉曼光谱（LCRS）对样品进行了表征.结果表明

PNMH-OSA凝胶是通过PNMH上的—NHNH2和OSA上的—CHO反应生成CN键而形成的化学交联凝胶；随着凝胶中PNMH量的增加

PNMH-OSA凝胶的温敏性增强

降解时间延长；温敏组分的含量对PNMH-OSA凝胶的溶胀和降解性能与温度的关系影响显著.

Abstract

A multifunctional macromolecule poly(N-isopropylacrylamide-co-methylacrylate-co-hydrazide)(PNMH) was prepared and used to cross-link oxidized sodium alginate (OSA) to form biodegradable and thermosensitive gels.Thermo-sensitivity and degradable properties of the gels were evaluated by measuring the transmittance at different temperatures and the time dependence of the swelling ratio in phosphate buffered saline

respectively.FTIR and LCRS were applied to characterize the samples.It is showed that gels are cross-linked by the forming of CN bonds.The macromolecule PNMH shows thermo-sensitivity.With increasing PNMH content

the thermo-sensitivity of gels is improved

and degradation time of gels becomes longer.In addition

the PNMH content has great effect on the temperation dependence of swelling and degradation of hydroels.

关键词

凝胶海藻酸钠温敏性降解

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