STUDY ON HYDROGELS OF β-CYCLODEXTRIN-CROSSLINKED ACRYLIC ACID AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR

HUANG Yi; FAN Xiaodong

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STUDY ON HYDROGELS OF β-CYCLODEXTRIN-CROSSLINKED ACRYLIC ACID AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR

Research Article | 更新时间：2021-03-19

- STUDY ON HYDROGELS OF β-CYCLODEXTRIN-CROSSLINKED ACRYLIC ACID AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR
- Acta Polymerica Sinica Issue 3, Pages: 505-509(2006)
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- Published：20 June 2006，
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HUANG Yi, FAN Xiaodong. STUDY ON HYDROGELS OF β-CYCLODEXTRIN-CROSSLINKED ACRYLIC ACID AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR. [J]. Acta Polymerica Sinica (3):505-509(2006)
DOI：

HUANG Yi, FAN Xiaodong. STUDY ON HYDROGELS OF β-CYCLODEXTRIN-CROSSLINKED ACRYLIC ACID AND THEIR CONTROLLED DRUG RELEASE BEHAVIOR. [J]. Acta Polymerica Sinica (3):505-509(2006) DOI：

摘要

采用1

3-二环己基碳化二亚胺(DCC)为缩合剂

通过β环糊精与丙烯酸的酯化反应合成了不同取代度的丙烯酸β环糊精酯(βCD6A)

以此为单体与丙烯酸通过氧化还原自由基引发聚合

合成出了不同交联密度和不同环糊精含量的新型水凝胶(AAβCD6A).溶胀实验表明

该类水凝胶均具有pH敏感性

溶胀动力学实验进一步对其机理进行了探讨.选择苯丁酸氮芥(CHL)作为模型药物

考察了不同pH下AAβCD6A水凝胶对药物释放行为的影响.结果表明

pH=6.8时药物释放率均大于pH=2.0时药物释放率

环糊精的存在表现出促释作用.

Abstract

β—cyclodextrin(β—CD)-containing acrylic monomers(β—CD-6一A)with different substitution degree were prepared by using dicyclohexylcarbodiimide(DCC)as condensation agent

and a functional hydrogel was synthesized by copolymerization of β-CD-6-A with acrylic acid(AA)using a redox initiator system in aqueous solutions．The nuclear magnetic resonance(1H—NMR)

infrared spectroscopy(IR)and swelling experiments were employed to characterize the β-CD modified monomers and their copolymers．The results show that the resin’s equilibrium swelling ratio(ESR)possesses pH—sensitivities．The mechanisms of controlled drug release were investigated by using an anti—cancer drug

chlorambucil(CHL)

as the model medicines at different medium．The release behavior of CHL from the hydrogels β-CD—AA indicated that the release ratio of CHL is affected by the pH value

and the cumulative release at pH=6．8 was higher than that at pH=2．0．In addition

the release efficiency of CHL from the hydrogels with β-CD is higher than that of the hydrogels without β-CD．

关键词

β-环糊精水凝胶pH敏感性药物控制释放

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浙江科技学院环境与资源学院

浙江大学高分子科学与工程学系高分子功能构造与合成教育部重点实验室

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