SYNTHESIS OF POLYURETHANE-GRAFT-SULFONATE AND ITS STUDY\=OF BLOOD-COMPATIBILITY

CHEN Baolin; JI Jian; JI Rentian; QIU Yongxing; FENG Linxian

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SYNTHESIS OF POLYURETHANE-GRAFT-SULFONATE AND ITS STUDY\=OF BLOOD-COMPATIBILITY

Research Article | 更新时间：2021-03-19

- SYNTHESIS OF POLYURETHANE-GRAFT-SULFONATE AND ITS STUDY\=OF BLOOD-COMPATIBILITY
- Acta Polymerica Sinica Issue 4, Pages: 449-453(1999)
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- Published：20 August 1999，
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CHEN Baolin, JI Jian, JI Rentian, QIU Yongxing, FENG Linxian. SYNTHESIS OF POLYURETHANE-GRAFT-SULFONATE AND ITS STUDY\=OF BLOOD-COMPATIBILITY. [J]. Acta Polymerica Sinica (4):449-453(1999)
DOI：

CHEN Baolin, JI Jian, JI Rentian, QIU Yongxing, FENG Linxian. SYNTHESIS OF POLYURETHANE-GRAFT-SULFONATE AND ITS STUDY\=OF BLOOD-COMPATIBILITY. [J]. Acta Polymerica Sinica (4):449-453(1999) DOI：

摘要

通过梳状的磺化聚氧乙烯接枝共聚醚和４

４’-二苯甲烷二异氰酸酯（ＭＤＩ）反应

合成了磺酸根离子和聚氧乙烯复合修饰的聚氨酯（ＰＥＵ-ｇ-ＰＥＯ-ＳＯ３Ｎａ）．通过血小板粘附试验对材料的体外抗凝血性试验表明将具有“类肝素”生物活性的磺酸根离子通过ＰＥＯ为“间隔臂”固定在聚醚氨酯上

不仅可以有效地阻抗血小板的粘附、活化

还可以有效地阻断内外源凝血途径

具有较好的血液相容性．

Abstract

A new reactive graft copolymer

poly(tetramethylene glycol)-graft-ω-propyl sodium sulfonate-poly(ethylene glycol)(PTMG-g-PEG-CH2CH2CH2SO-3Na+)

was synthesized by the cationic polymerization of a

ω-bifunctional PEG macromonomer ( O—CH2—PEG—CH2CH2CH2SO3Na ) and THF.Polyurathane-graft-ω-propyl sodium sulfonate-poly(ethylene glycol) (PEU-g-PEO-CH2CH2CH2SO-3Na+)

was synthesized by using the copolymer as a polyether.In vitro blood-compatibility tests results indicated that the sulfonate-modified polyurathane can resist platelet adhesion and is more blood-compatible.

关键词

聚氨酯类肝素血液相容性

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