COMPATIBILITY AND DEGRADATION OF NOVEL POLYPHOSPHAZENE/ POLYANHYDRIDE BLENDS

QIU Liyan; ZHU Kangjie

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COMPATIBILITY AND DEGRADATION OF NOVEL POLYPHOSPHAZENE/ POLYANHYDRIDE BLENDS

Research Article | 更新时间：2021-03-19

- COMPATIBILITY AND DEGRADATION OF NOVEL POLYPHOSPHAZENE/ POLYANHYDRIDE BLENDS
- Acta Polymerica Sinica Issue 5, Pages: 660-664(2001)
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- Published：20 October 2001，
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QIU Liyan, ZHU Kangjie. COMPATIBILITY AND DEGRADATION OF NOVEL POLYPHOSPHAZENE/ POLYANHYDRIDE BLENDS. [J]. Acta Polymerica Sinica (5):660-664(2001)
DOI：

QIU Liyan, ZHU Kangjie. COMPATIBILITY AND DEGRADATION OF NOVEL POLYPHOSPHAZENE/ POLYANHYDRIDE BLENDS. [J]. Acta Polymerica Sinica (5):660-664(2001) DOI：

摘要

采用溶液混合法制备了聚 [(双-甘氨酸乙酯)膦腈 ](PGP)与聚酸酐(PSA或PSTP)的共聚物 .利用示差扫描量热仪和相差显微镜研究了两体系的共混相容性

发现PGP与PSTP具有部分相容性.体外降解试验表明

PGP PSTP降解行为呈均一性

且由于PSTP酸性产物的催化作用

降解速度明显较PGP加快 (约15天)并随PSTP含量增加而加快 .PGP PSTP有望成为一种新型的药物控释载体材料.

Abstract

Poly[bis(glycine ethyl ester)phosphazene] was blended with polyanhydride (PSA or PSTP) in various ratios using solvent-mixing technique．The compatibility of these blends was evaluated by DSC and contrast microscopy method．The results showed that PGP was partially compatible with PSTP．In vitro degradation experiment was conducted in distilled water at 37℃．The degradation behavior of PGP／PSTP blends exhibited homogenious．Furthermore

the degradation rate was much faster than that of PGP and could be regulated by adjusting PSTP content due to the catalyze effect of acidic products of PSTP．PGP／PSTP blends could be a series of potential biomaterials for drug controlled release．

关键词

聚膦腈聚酸酐聚合物共混相容性降解性药物控释

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