SWELLING KINETICS OF HYDROGELS FOR COLONIC-SITE DRUG DELIVERY

YIN Yihua; YANG Yajiang; XU Huibi

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SWELLING KINETICS OF HYDROGELS FOR COLONIC-SITE DRUG DELIVERY

Research Article | 更新时间：2021-03-19

- SWELLING KINETICS OF HYDROGELS FOR COLONIC-SITE DRUG DELIVERY
- Acta Polymerica Sinica Issue 5, Pages: 650-655(2001)
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- Published：20 October 2001，
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YIN Yihua, YANG Yajiang, XU Huibi. SWELLING KINETICS OF HYDROGELS FOR COLONIC-SITE DRUG DELIVERY. [J]. Acta Polymerica Sinica (5):650-655(2001)
DOI：

YIN Yihua, YANG Yajiang, XU Huibi. SWELLING KINETICS OF HYDROGELS FOR COLONIC-SITE DRUG DELIVERY. [J]. Acta Polymerica Sinica (5):650-655(2001) DOI：

摘要

合成了带不同疏水侧基的甲基丙烯酸酯、甲基丙烯酰胺及丙烯酸与 4

4′ 二 (甲基丙烯酰胺基 )偶氮苯交联共聚的凝胶 .主要研究了这类凝胶在pH =2 .2至pH =7.4的缓冲溶液的溶胀特性 .其溶胀过程遵循二级溶胀动力学

影响这类凝胶溶胀行为的因素包括交联程度、疏水基链的长度、pH值等 .通过调节这些因素是完全可以控制凝胶在小肠内的溶胀程度

进而避免凝胶内部的药物被提前释放

Abstract

Hydrogels based on n-alkyl methacrylate esters (n-AMA)

acrylic acid and acrylamide cross-linked with 4

4′-di(methacryloylmino)azobenzene were preparared．Swelling behavior of the hydrogels was studied by immersion of slabs of samples in buffered solutions of pH values 2.2～7.4．The process of swelling follows Schott second-order diffusion kinetics．The factors influencing the swelling behavior of the gels include：the degree of cross-linking

the lengths of the n-AMA side chains

pH values et al．

关键词

可降解凝胶溶胀动力学

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