BIODEGRADATION AND DRUG RELEASE BEHAVIOR OF A NOVEL POLYESTER /POLYANHYDRIDE BLENDS SYSTEM

TANG Aijun; HE Xiaohui; LI Fumian

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BIODEGRADATION AND DRUG RELEASE BEHAVIOR OF A NOVEL POLYESTER /POLYANHYDRIDE BLENDS SYSTEM

Research Bulletin | 更新时间：2021-03-19

- BIODEGRADATION AND DRUG RELEASE BEHAVIOR OF A NOVEL POLYESTER /POLYANHYDRIDE BLENDS SYSTEM
- Acta Polymerica Sinica Issue 4, Pages: 486-489(1996)
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- Published：20 August 1996，
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TANG Aijun, HE Xiaohui, LI Fumian. BIODEGRADATION AND DRUG RELEASE BEHAVIOR OF A NOVEL POLYESTER /POLYANHYDRIDE BLENDS SYSTEM. [J]. Acta Polymerica Sinica (4):486-489(1996)
DOI：

TANG Aijun, HE Xiaohui, LI Fumian. BIODEGRADATION AND DRUG RELEASE BEHAVIOR OF A NOVEL POLYESTER /POLYANHYDRIDE BLENDS SYSTEM. [J]. Acta Polymerica Sinica (4):486-489(1996) DOI：

摘要

聚酯／聚酸酐共混体系的降解和药物释放行为唐爱军

贺晓晖

李福绵（北京大学化学系北京１００８７１）关键词聚癸二酸

聚乳酸

聚己内酯

降解行为

药物释放行为聚酸酐

特别是脂肪类聚酸酥由于其化学价键的水解活泼性

是一类快速生物降解材料．由于聚酸团的水解机制是表面水解

以聚酸配为基体的药物送达体系可实现零级释放［‘］．但是由于酸配的熔融缩聚过程中的成环平衡和热分解反应

难以得到分子量大的聚酸研

因而?...

Abstract

Poly(sebacic anhydride) (PSA) was prepared from the mixed anhydride of diacid. PSA was blended with polylactone (PLA) and polycaprolactone (PCL) respectively. The blends were fabricated into film by solvent casting. Hydrolytic degradation and drug release experiments were carried out in 0.1 mol /1 phosphate buffer PH 7.4 at 37℃ by examining the changes in weight

molecular weight

DSCcurve. Indomethacinum and p-nitroauiline were used as model drugs. Samples with a higher portion of PSA showed higher degradation rate.Rate of release depended on the content of PSA and the properties of drug.All systems demonstrated burst release during the first few days.

关键词

聚癸二酸聚乳酸聚己内酯降解行为药物释放行为

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Key laboratory of Auxiliary Chemistry and Technology for Chemical Industry of Ministry of Education, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology

扬州大学化学化工学院

扬州大学江苏省环境工程与环境材料重点实验室

扬州大学测试中心

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