The copolyester-polyether (or polyesteramide-polyether) multiblock copolymers with meso-genic units in the hard segments were synthesized by the acidolysis of a polyesterpolyether multi-block copolymer with p-acetoxybenzoic acid (or p-acetamidobenzoic acid) followed by polycon-densation reaction through the acetoxy (or acetamido) and carboxyl groups. The optically an-isotropic textures of these mukiblock copolymers in the melt have been studied.