Six polyamides containing 5-fluorouracil in the side chain were synthesized by the condensation of di-p-nitrophenyl N-(5-fluorouracil-l-acetyl)-glutamate with a series of polymethy-lene diamines. All of the new polyamides obtained are solid powder and soluble in water. Their chemical structures were identified by 1H-NMR

UV and IR spectra as well as elemental analysis. The antitumor activity of some of these polyamides were tested against Ehrlich ascites carcinoma in mice. Poly [ethylene α-(5-fluorouracil-l-acetyl-amino) glutaramide] showed an inhibition rate of 43%.