A new synthetic method for biomedical materials poly (ε-caprolactone)(PCL) initiated by the catalyst Ti(OBu)4 has been investigated．The test has shown that the average degree of polymerization DP is linear with monomer／initiator M/I．The relationship between the．poly-met molecular weight Mw and reaction temperature，reaction time also is obtained PCL is characterised by IR，1H-NMR

13C-NMR and DSC．The analysis results indicated that PCL synthesized by this method is no difference as compared to that obtained by other methods on polymer structure and performance．In vitro the Nifidipine and Lauryl Alcohol microspheres prepared by the solvent evapora-tion method using this materials as substrate were found to give excellent sustained release performance．