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The Applications of Molecular Bottlebrush in Nanomedicine
- Acta Polymerica Sinica Vol. 51, Issue 6, Pages: 609-619(2020)
- 作者机构：
中山大学材料科学与工程学院 聚合物复合材料及功能材料教育部重点实验室 广州 510275
- 作者简介：
- 基金信息：
DOI：10.11777/j.issn1000-3304.2020.20021
CLC：Published：2020-6，
Published Online：29 April 2020，
Received：7 February 2020，
Revised：4 March 2020，
扫 描 看 全 文
Zi-yang Sun, Hua-an Li, Hua-hua Huang, Yi Shi, Yong-ming Chen. The Applications of Molecular Bottlebrush in Nanomedicine. [J]. Acta Polymerica Sinica 51(6):609-619(2020)
Zi-yang Sun, Hua-an Li, Hua-hua Huang, Yi Shi, Yong-ming Chen. The Applications of Molecular Bottlebrush in Nanomedicine. [J]. Acta Polymerica Sinica 51(6):609-619(2020) DOI： 10.11777/j.issn1000-3304.2020.20021.
摘要
聚合物分子刷是一种通过共价键连接的单分子纳米材料，与通过超分子自组装获得的纳米组装体相比，其在复杂的生理环境中具有更好的循环稳定性. 另外，可以通过调控聚合物分子刷主链与侧链的相对长度，即调控长径比，获得类似于球状、棒状、蠕虫状的纳米颗粒，为研究具有相同化学组成不同形貌的纳米颗粒的生理行为提供了研究平台. 因此，本文总结了近十年来聚合物分子刷在小分子药物输送、基因负载、生物成像等纳米医学领域的相关研究进展，并展望了聚合物分子刷在纳米医学领域的发展前景.
Abstract
Molecular bottlebrushes (MBB)
as a special kind of grafted polymers
have densely grafted with side chains along a linear polymer backbone that often show a wormlike single chain morphology
representing a promising one-dimensional unimolecular nanomaterial. MBB attracts much attention from material scientists on account of its unique structure as well as unique properties. Benefited from the development of controlled living polymerization and click chemistry over the years
it allows excellent control over their synthesis and structural compositions
showing the great diversity of its structure and functionality. As compared with nanomaterials based on self-assembly
brush polymers have lots of advantages
including favorable stability
tunable sizes and morphologies
facile synthesis
and flexible compositions
that make them promising nanocarriers and capable of loading more and multiple “cargos” within one molecule. In addition
by adjusting the relative length of the backbone and side chain of molecular bottlebrush
that is
adjusting the ratio of length to diameter
nanomaterials with the shape of sphere
rod and worm can be obtained
providing a research platform for studying the physiological behavior of nanomaterials with the same chemical composition but different morphologies. Herein
this review aims to summarize the recent research progress in the application of molecular bottlebrush in the field of nanomedicine
such as small molecule drug delivery
gene loading and biological imaging
and the future development and challenges of molecular bottlebrush in nanomedicine field have also been discussed.
关键词
聚合物分子刷单分子纳米颗粒纳米医学纳米载药系统生物成像
Keywords
Molecular bottlebrushUnimolecular nanoparticleNanomedicineDrug delivery systemBiological imaging
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