Synthesis and Properties of Dynamic Hydrogels Based on Host-guest Chemistry of Cucurbit[8]uril and Its Two Different Homodimer Guests

Peng-liang Zhang; Ying-ying Zhang; Xin-tong Li; Jia-jun Ren; Lei Zou; Zhuo Zhao; Si-jia Gao; Ya-fei Wang; Yan Zhang; Ying Luo; Yong-jun Zhang

doi:10.11777/j.issn1000-3304.2023.23168

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Synthesis and Properties of Dynamic Hydrogels Based on Host-guest Chemistry of Cucurbit[8]uril and Its Two Different Homodimer Guests

Research Article | 更新时间：2024-01-03

- Synthesis and Properties of Dynamic Hydrogels Based on Host-guest Chemistry of Cucurbit[8]uril and Its Two Different Homodimer Guests
- Acta Polymerica Sinica Vol. 55, Issue 1, Pages: 79-90(2024)
- 作者机构：
  
  1.天津工业大学，材料科学与工程学院，天津市肝胆疾病研究所天津市重症疾病体外生命支持重点实验室天津 300170
  2.天津工业大学，药学院，天津市肝胆疾病研究所天津市重症疾病体外生命支持重点实验室天津 300170
  3.(天津工业大学，化学学院天津 300387) (，天津市肝胆疾病研究所天津市重症疾病体外生命支持重点实验室天津 300170)
  4.天津工业大学，天津市第三中心医院，天津市肝胆疾病研究所天津市重症疾病体外生命支持重点实验室天津 300170
- 作者简介：
  
  Lei Zou, E-mail: zoulei@tiangong.edu.cn
  Yong-jun Zhang, E-mail: zhangyj@tiangong.edu.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2023.23168
  CLC：
- Published：20 January 2024，
  
  Published Online：21 November 2023，
  
  Received：20 July 2023，
  
  Accepted：25 August 2023
- 稿件说明：
移动端阅览
张鹏亮, 张莹莹, 李新桐, 任家骏, 邹磊, 赵琢, 高偲嘉，王亚斐，张岩，骆莹，张拥军. 基于葫芦[8]脲主客体化学的双客体组分动态交联水凝胶的制备和性能研究. 高分子学报, 2024, 55(1), 79-90

Zhang, P. L.; Zhang, Y. Y.; Li, X. T.; Ren, J. J.; Zou, L.; Zhao, Z.; Gao, S. J.; Wang, Y. F.; Zhang, Y.; Luo, Y.; Zhang, Y. J. Synthesis and properties of dynamic hydrogels based on host-guest chemistry of cucurbit[8]uril and its two different homodimer guests. Acta Polymerica Sinica, 2024, 55(1), 79-90
张鹏亮, 张莹莹, 李新桐, 任家骏, 邹磊, 赵琢, 高偲嘉，王亚斐，张岩，骆莹，张拥军. 基于葫芦[8]脲主客体化学的双客体组分动态交联水凝胶的制备和性能研究. 高分子学报, 2024, 55(1), 79-90 DOI： 10.11777/j.issn1000-3304.2023.23168.

Zhang, P. L.; Zhang, Y. Y.; Li, X. T.; Ren, J. J.; Zou, L.; Zhao, Z.; Gao, S. J.; Wang, Y. F.; Zhang, Y.; Luo, Y.; Zhang, Y. J. Synthesis and properties of dynamic hydrogels based on host-guest chemistry of cucurbit[8]uril and its two different homodimer guests. Acta Polymerica Sinica, 2024, 55(1), 79-90 DOI： 10.11777/j.issn1000-3304.2023.23168.

摘要

基于超分子主客体作用的动态交联在构筑用于生物大分子和细胞载体的可注射水凝胶输送材料方面具备很多优势，但单一性质交联点的动态快慢程度固定，无法进行调节，难以实现水凝胶动态可调的性能. 本研究利用葫芦[8]脲(CB[8])能够与它的客体分子以摩尔比为1/2的比例形成同种三元复合物主客体的相互作用，设计了一种双组分超分子动态交联水凝胶系统. 在水凝胶聚合物骨架的侧链上同时引入偶氮苯与苯基吡啶盐2种客体基团，其中偶氮苯客体与CB[8]的结合较弱，呈现较快的动态可逆性质；苯基吡啶盐客体与CB[8]的结合较强，呈现较慢的动态可逆性质. 设计不同比例的2种动态交联，得到了系列网络结构相同，但交联点性质动态可调的水凝胶材料. 水凝胶性能研究结果显示，得到的材料能够在流变学机械性能、自修复、剪切变稀、应力松弛、大分子药物释放等生物医用关键性质上随客体比例变化而进行调控，具备良好的应用前景.

Abstract

Dynamic crosslinking based on host-guest interaction has shown a number of advantages in constructing injectable hydrogel to be used for biomacromolecules and cell delivery materials. However

it is difficult to dynamically adjust the performance of the hydrogel with only one kind of crosslinking point presented in the structure of the hydrogel. In this study

a two-component supramolecular dynamic cross-linking hydrogel system was designed

employing the host-guest interaction between cucurbit[8]uril (CB[8]) and its homodimer guests to form ternary complex at a ratio of 1/2. The azobenzene guest residues and the phenyl pyridinium guest motifs were introduced into the side chain of hydrogel backbone polymer

in which the azobenzene guest would weakly bind with CB[8] showing faster dynamics

and the phenyl pyridinium salt guest would tightly bind with CB[8] showing slower dynamics. A series of hydrogel materials with the same network structure but dynamically adjustable properties were prepared by adjusting the proportions of these two dynamic cross-linking points. The obtained hydrogel materials could continuously change their properties such as rheology mechanical properties

self-healing

shear thinning

stress relaxation behavior

and macromolecular drug release

all of which are essential in biomedical fields and thus showed great potential in relevant applications.

关键词

葫芦[8]脲水凝胶主客体化学动态交联

Keywords

Cucurbit[8]urilHydrogelHost-guest chemistryDynamic cross-linking

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