The Research Progress on One-component Photodiagnostic Nanomaterials Based on <italic style="font-style: italic">π</italic>-Conjugated Amphiphilic Polymers

Sheng-xin Hou; Song-nan Qu; Lei-lei Tian

doi:10.11777/j.issn1000-3304.2024.24170

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The Research Progress on One-component Photodiagnostic Nanomaterials Based on π-Conjugated Amphiphilic Polymers

Review | 更新时间：2025-01-10

- The Research Progress on One-component Photodiagnostic Nanomaterials Based on π-Conjugated Amphiphilic Polymers
- Acta Polymerica Sinica Vol. 55, Issue 12, Pages: 1622-1647(2024)
- 作者机构：
  
  1.澳门大学应用物理及材料工程研究院澳门特别行政区 999067
  2.南方科技大学材料科学与工程系深圳 518055
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2024.24170
  CLC：
- CSTR：32057.14.GFZXB.2024.7280
- Published：20 December 2024，
  
  Published Online：21 October 2024，
  
  Received：16 June 2024，
  
  Accepted：2024-07-12
- 稿件说明：
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侯胜鑫, 曲松楠, 田雷蕾.亲疏水一体化策略构筑π共轭光诊疗纳米材料的研究进展.高分子学报, 2024, 55(12), 1622-1647

Hou, S. X.; Qu, S. N.; Tian, L. L. The research progress on one-component photodiagnostic nanomaterials based on π-conjugated amphiphilic polymers. Acta Polymerica Sinica, 2024, 55(12), 1622-1647
侯胜鑫, 曲松楠, 田雷蕾.亲疏水一体化策略构筑π共轭光诊疗纳米材料的研究进展.高分子学报, 2024, 55(12), 1622-1647 DOI： 10.11777/j.issn1000-3304.2024.24170. CSTR： 32057.14.GFZXB.2024.7280.

Hou, S. X.; Qu, S. N.; Tian, L. L. The research progress on one-component photodiagnostic nanomaterials based on π-conjugated amphiphilic polymers. Acta Polymerica Sinica, 2024, 55(12), 1622-1647 DOI： 10.11777/j.issn1000-3304.2024.24170. CSTR： 32057.14.GFZXB.2024.7280.

摘要

有机光诊疗

共轭分子由于明确的分子结构、丰富的激发态性质、大的摩尔吸光系数以及优异的生物安全性，在生物成像和肿瘤治疗方面展示出巨大的应用潜力. 然而，

共轭分子的强疏水性严重制约了它在生物体内的实际应用. 目前的研究致力于利用两亲性的聚合物载体包裹疏水分子以达到在水中分散的目的，这可能会导致不可控的分子泄露并造成严重的肝脾富集. 合成

共轭双亲聚合物构建一体化胶束是增强生物安全性，实现体内光诊疗应用的理想手段. 本文首先介绍了光诊疗

共轭分子的种类和分子结构设计，及其光物理化学性质. 其次，详细探讨了一体化胶束的构建方法，主要包括聚合物直接接枝(graft to)和

共轭分子参与聚合(graft from) 2种方式. 同时，对一体化胶束构建过程中使用亲水性高分子种类及功能进行了分类探讨，主要包括非生物大分子聚乙二醇和聚两性离子以及生物大分子核酸、多肽、多糖等. 最后，讨论了一体化胶束的独特性质及其在调控分子组装结构、调节生物体代谢性质、细胞和活体成像以及肿瘤治疗等方面的应用. 并对一体化的有机光诊疗纳米胶束在生物医学领域的研究进展进行了总结和展望.

Abstract

Organic phototheranostic

‍-conjugated molecules exhibit great potential for bioimaging and tumor therapy applications due to their well-defined molecular structures

abundant excited state properties

large molar absorption coefficients

and excellent biosafety. However

the strong hydrophobicity of

‍-conjugated molecules severely restricts their practical applications in organisms. Current research is devoted to using amphiphilic polymer carriers to encapsulate hydrophobic

‍-conjugated molecules for water dispersion. This may lead to uncontrollable molecular leakage and cause severe liver and spleen enrichment. Synthesis of

‍-conjugated amphiphilic polymers and construction of one-component micelles have become an emerging strategy for developing phototheranostic materials. In this review

we summarized the recent research progress on one-component phototheranostic nanomaterials based on

‍-conjugated amphiphilic polymers. First

the category of phototheranostic

‍-conjugated molecules is introduced. Secondly

the constructions of one-component micelles are discussed in detail. The synthesis of

‍-conjugated amphiphilic polymers mainly includes the "graft to" and "graft from" methods. Also

the hydrophilic polymers for the synthesis of

‍-conjugated amphiphilic polymers are classified and discussed

mainly including synthetic polymers

such as polyethylene glycol and zwitterionic polymer

and biological macromolecules

like nucleic acids

peptides

polysaccharides and so on. Finally

the unique properties of these one-component

‍-conjugated nanomaterials and their applications in regulating molecular assembly

enhancing biocompatible properties

cellular a

nd clinical imaging

and tumor therapy are reviewed.

关键词

光诊疗π共轭分子水溶性高分子一体化胶束

Keywords

Phototheranosticsπ‍-Conjugated moleculesWater-soluble polymerOne-component micelles

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The Research Progress on One-component Photodiagnostic Nanomaterials Based on π-Conjugated Amphiphilic Polymers

DOI：10.11777/j.issn1000-3304.2024.24170

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