基于动态共价键的纳米载体用于蛋白质药物递送的研究进展

Su-ning He; Sai-nan Liu; Ting-ting Zhang; Lin-qi Shi; Ru-jiang Ma

doi:10.11777/j.issn1000-3304.2025.25027

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基于动态共价键的纳米载体用于蛋白质药物递送的研究进展

更新时间：2025-04-25

- 基于动态共价键的纳米载体用于蛋白质药物递送的研究进展
- Acta Polymerica Sinica Pages: 1-20(2025)
- 作者机构：
  
  南开大学化学学院高分子化学研究所功能高分子材料教育部重点实验室天津 300071
- 作者简介：
  
  Lin-qi Shi, E-mail: shilinqi@nankai.edu.cn
  Ru-jiang Ma, E-mail: marujiang@nankai.edu.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2025.25027
  CLC：
- CSTR：32057.14.GFZXB.2025.7370
- Received：24 January 2025，
  
  Accepted：2025-02-24，
  
  Published Online：24 April 2025，
- 稿件说明：
移动端阅览
何苏宁, 刘赛男, 张婷婷, 史林启, 马如江. 基于动态共价键的纳米载体用于蛋白质药物递送的研究进展. 高分子学报, doi: 10.11777/j.issn1000-3304.2025.25027

He, S. N.; Liu, S. N.; Zhang, T. T.; Shi, L. Q.; Ma, R. J. The Research progress on dynamic covalent bonding-based nanocarriers for protein drug delivery. Acta Polymerica Sinica, doi: 10.11777/j.‍issn1000-3304.2025.25027
何苏宁, 刘赛男, 张婷婷, 史林启, 马如江. 基于动态共价键的纳米载体用于蛋白质药物递送的研究进展. 高分子学报, doi: 10.11777/j.issn1000-3304.2025.25027 DOI： CSTR： 32057.14.GFZXB.2025.7370.

He, S. N.; Liu, S. N.; Zhang, T. T.; Shi, L. Q.; Ma, R. J. The Research progress on dynamic covalent bonding-based nanocarriers for protein drug delivery. Acta Polymerica Sinica, doi: 10.11777/j.‍issn1000-3304.2025.25027 DOI： 10.11777/j.issn1000-3304.2025.25027. CSTR： 32057.14.GFZXB.2025.7370.

摘要

与小分子药物相比，蛋白质药物具有特异性高、毒性小的优点，在许多重大疾病的治疗中发挥重要作用. 但蛋白质药物在临床应用中也面临诸多挑战，如稳定性差，免疫原性强，易被快速降解、清除等，最终导致其生物利用度低. 为此，人们构建了多种蛋白质药物递送体系以解决上述问题. 利用动态共价键构建的递送体系不仅能提高蛋白质药物在递送过程中的稳定性，还能实现病灶部位的刺激响应性药物释放，有效提高蛋白质药物的生物利用度和治疗效果. 本文概述了利用共价键、非共价相互作用以及动态共价键构建的蛋白质药物递送体系，重点介绍了基于动态共价键的蛋白质药物递送体系的构建方法、药物释放机制以及最新应用研究进展，以期为开发更加高效、实用的蛋白质药物递送体系提供借鉴.

Abstract

Compared to small molecule drugs

protein drugs exhibit high specificity and low toxicity

making them pivotal in the treatment of numerous serious diseases. Nevertheless

they confront several challenges in clinical application

including instability

high immunogenicity

and susceptibility to rapid degradation and elimination

ultimately resulting in low bioavailability. To overcome these hurdles

various protein drug delivery systems have been devised. Notably

delivery systems utilizing dynamic covalent bonds not only bolster the stability of protein drugs during the delivery process but also facilitate stimulus-responsive drug release at the target site

thereby significantly enhancing the bioavailability and therapeutic efficacy of protein drugs. This paper briefly introduces protein drug delivery systems based on covalent bonds

non-covalent interactions

and dynamic covalent bonds. It comprehensively reviews the construction methodologies

drug release mechanisms

and the latest advancements in the application of protein drug delivery systems based on dynamic covalent bonds. The aim is to provide insights and guidance for the development of more efficient and practical protein drug delivery systems.

关键词

Keywords

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Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Key Laboratory of High Performance Polymer Based Composites of Guangdong Province, School of Chemistry, Sun Yat-Sen University

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