Study on Silk Fibroin-based Flexible Ion-selective Neural Electrodes

Qi-mei Huang; Zhan-ao Hu; Jing-jing Geng; Xiang Yao; Yao-peng Zhang

doi:10.11777/j.issn1000-3304.2025.25240

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Study on Silk Fibroin-based Flexible Ion-selective Neural Electrodes

Research Article | 更新时间：2026-03-23

- Study on Silk Fibroin-based Flexible Ion-selective Neural Electrodes
- Acta Polymerica Sinica Vol. 57, Issue 3, Pages: 695-708(2026)
- 作者机构：
  
  东华大学材料科学与工程学院先进纤维材料全国重点实验室上海 201620
- 作者简介：
  
  Xiang Yao, E-mail: yaoxiang@dhu.edu.cn
  Yao-peng Zhang, E-mail: zyp@dhu.edu.cn
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2025.25240
  CLC：
- CSTR：32057.14.GFZXB.2025.7529
- Received：12 September 2025，
  
  Accepted：02 December 2025，
  
  Online First：08 January 2026，
  
  Published：20 March 2026
- 稿件说明：
移动端阅览
黄启楣, 胡展翱, 耿敬敬, 姚响, 张耀鹏. 丝素蛋白基离子选择性柔性神经电极的研究. 高分子学报, 2026, 57(3), 695-708.

Huang, Q. M.; Hu, Z. A.; Geng, J. J.; Yao, X.; Zhang, Y. P. Study on silk fibroin-based flexible ion-selective neural electrodes. Acta Polymerica Sinica (in Chinese), 2026, 57(3), 695-708.
黄启楣, 胡展翱, 耿敬敬, 姚响, 张耀鹏. 丝素蛋白基离子选择性柔性神经电极的研究. 高分子学报, 2026, 57(3), 695-708. DOI： 10.11777/j.issn1000-3304.2025.25240. CSTR： 32057.14.GFZXB.2025.7529.

Huang, Q. M.; Hu, Z. A.; Geng, J. J.; Yao, X.; Zhang, Y. P. Study on silk fibroin-based flexible ion-selective neural electrodes. Acta Polymerica Sinica (in Chinese), 2026, 57(3), 695-708. DOI： 10.11777/j.issn1000-3304.2025.25240. CSTR： 32057.14.GFZXB.2025.7529.

摘要

为开发在体微量离子信号的监测电极，选用具有优异生物相容性和低模量特征的丝素蛋白(silk fibroin，SF)薄膜作为基底，选用导电高分子聚(3

4-乙烯二氧噻吩)-聚(苯乙烯磺酸盐) (PEDOT:PSS)作为柔性导电材料，结合喷墨打印技术和热温辅助图案转移技术，在柔性SF膜基底上制备了高导电的PEDOT:PSS电极通路. 在PEDOT:PSS电极末端，按需集成了具有K

、Ca

或Na

选择性的电极功能层，构筑了具有单一离子信号监测功能的SF基离子选择性柔性神经电极. 在此基础上，在SF膜上进一步集成了可同时监测2种离子信号的多个通道，构筑了具有良好多重离子响应功能和细胞相容性的柔性神经电极.

Abstract

Studies

indicate that abnormal electrical/chemical signals transmitted between the brain and the peripheral nervous system is the direct cause of degenerative neurological diseases. Consequently

real-time and accurate detection of interstitial ion concentration changes during their neurological disease onset is crucial for understanding pathogenesis and developing treatment strategies. Solid-contact ion-selective electrodes (SC-ISEs)

with their advantages such as simple structure

low cost

and high sensitivity

have shown promise as effective tools for

in vivo

detection. However

conventional metal-based SC-ISEs possess a higher elastic modulus compared with flexible alternatives

posing a risk of tissue damage during

in vivo

use. Moreover

they have drawbacks such as the need for secondary surgery to remove the device after signal acquisition. Therefore

developing low-modulus

degradable

miniaturized

flexible ion-selective neural electrodes holds significant value for the real-time and accurate detection of neural ion signals. This study utilizes silk fibroin (SF)

which is chosen for its excellent biocompatibility and low elastic modulus

as the substrate layer. Conductive polymer poly(3

4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) serves as the flexible electrode layer. Combining ink-jet printing and the thermo-assisted pattern transfer technology

we fabricated a flexible SF-based electrode integrating both good flexibility and conductivity. By incorporating K⁺

Ca²⁺

or Na⁺ selective electrode functional layers at the electrode tip contact sites

single-channel SF-based ion-selective flexible neural electrodes were prepared. To achieve simultaneous monitoring of multiple ions

a multi-channel integrated SF-based ion-selective electrodes capable of detecting dual-ion signals were further developed. The electrodes exhibit excellent multi-ion response capabilities and good cell compatibility. This study provides significant references for developing practical deg

radable and miniaturized multi-ion selective flexible neural electrodes

offering new strategies for monitoring trace ion signals

in vivo

关键词

Keywords

references

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