RESEARCH ON THE SURFACE PROPERTIES OF POLY(LACTIC ACID) MODIFIED BY CARBOXYMETHYLATED LENTINAN

Yi-feng Wang; Xin-xin Lian; Zhong-kui Wu; Yan-fei Xiong

doi:10.3724/SP.J.1105.2012.11419

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RESEARCH ON THE SURFACE PROPERTIES OF POLY(LACTIC ACID) MODIFIED BY CARBOXYMETHYLATED LENTINAN

Research Article | 更新时间：2021-03-19

- RESEARCH ON THE SURFACE PROPERTIES OF POLY(LACTIC ACID) MODIFIED BY CARBOXYMETHYLATED LENTINAN
- Acta Polymerica Sinica Issue 10, Pages: 1164-1169(2012)
- 作者机构：
  
  1. 材料科学与工程学院高分子材料与工程系
  2. 理学院生命科学与技术系武汉 430070>
- 作者简介：
- 基金信息：
- DOI：10.3724/SP.J.1105.2012.11419
  CLC：
- Published：20 October 2012，
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Yi-feng Wang, Xin-xin Lian, Zhong-kui Wu, Yan-fei Xiong. RESEARCH ON THE SURFACE PROPERTIES OF POLY(LACTIC ACID) MODIFIED BY CARBOXYMETHYLATED LENTINAN. [J]. Acta Polymerica Sinica (10):1164-1169(2012)
DOI：

Yi-feng Wang, Xin-xin Lian, Zhong-kui Wu, Yan-fei Xiong. RESEARCH ON THE SURFACE PROPERTIES OF POLY(LACTIC ACID) MODIFIED BY CARBOXYMETHYLATED LENTINAN. [J]. Acta Polymerica Sinica (10):1164-1169(2012) DOI： 10.3724/SP.J.1105.2012.11419.

摘要

制备了香菇多糖羧甲基衍生物

再通过化学接枝方法利用共价键将羧甲基香菇多糖固定在氨基化聚乳酸基材表面

得到羧甲基香菇多糖化学接枝修饰的聚乳酸材料.此外

通过在氨基化聚乳酸基材表面进行羧甲基香菇多糖与壳聚糖的层层自组装

得到生物多糖层层自组装修饰的聚乳酸材料.采用扫描电子显微镜、水接触角测量仪、抗菌活性测试、溶血试验和血栓试验等方法对被修饰聚乳酸材料的表面性能和生物性能进行了分析和比较.结果表明采用2种表面修饰方法得到的羧甲基香菇多糖修饰的聚乳酸材料的亲水性、血液相容性以及对大肠杆菌抗菌活性得到改善.与化学接枝方法相比

经过羧甲基香菇多糖与壳聚糖层层自组装修饰的聚乳酸材料具有更好的亲水性、血液相容性和抗菌活性.

Abstract

Lentinan

a mushroom polysaccharide

isolated from Lentinus edodes (Shiitake mushroom) was carboxymethylated in NaOH and isopropanol solution to obtain a water-soluble derivative.Then

carboxymethylated lentinan was covalently immobilized onto the surface of aminated poly(lactic acid) (PLA) substrates via chemical grafting method.In addition

carboxymethylated lentinan and chitosan were alternatively deposited on the aminated PLA substrates via layer-by-layer (LbL) assembly method

in order to construct a polysaccharide-based multilayer on the substrates.The carboxymethylated lentinan was proved by infrared spectroscopy.The degree of substitution and molecular weight (Mw) of carboxymethylated lentinan were determined by UV spectrophotometry and gel permeation chromatography (GPC)

respectively.The modified and unmodified PLA surfaces were investigated by scanning electron microscope (SEM) and water contact angle measurements.The hemolysis test

thrombus test

and the antibacterial activity against Escherichia coli of modified and unmodified PLA were tested in vitro

respectively.Then

the surface properties of PLA modified by different modification methods were evaluated and compared.The results showed that the hydrophilicity

blood compatibility

and antibacterial activity against Escherichia coli of PLA modified by LbL assembly and chemical grafting were both improved.In addition

PLA modified by carboxymethylated lentinan and chitosan through LbL assembly method showed better hydrophilicity

blood compatibility

and antibacterial activity against Escherichia coli

in comparison with that modified by chemical grafting method.

关键词

聚乳酸羧甲基香菇多糖表面修饰化学接枝层层自组装

Keywords

Poly(lactic acid)Carboxymethylated lentinanSurface modificationChemical graftingLayer-by-layer assembly

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Related Institution

State Key Laboratory of Organic-Inorganic Composite Materials, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology

ZheJiang Shiny New Materials Co., Ltd.

Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences

College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering of China, Sichuan University

Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University

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