A novelβ-cyclodextrin (β-CD) based monomer (MAH-β-CD) containing vinyl and earboxyl functional groups was synthesized by reaction ofβ-CD with maleic anhydride (MAH) in N

N-dimethylformamide (DMF) at 80℃．Through copolymerization of this functional monomer with N-isopropylacrylamide (NIPA) in aqueous solution

a novel hydrogel (poly(NIPA-co-MAH-β-CD) with pH-

temperature- and ionic strength sensitivities as well as with molecular inclusion behavior

was obtained using radical polymerization method．Both MAH-β-CD monomer and the gels obtained were characterizited using 13C-NMR

IR spectra

and element analysis．The equilibrium swelling ratios (ESR) of the hydrogels have been investigated under conditions of different pH

temperature and ionic strength．The results indicated that the ESR presents remarkable response to changes of pH

temperature

or ionic strength．Interestingly

under higher content of —COOH groups and weak base

the hydrogel still possesses evidently temperature-sensitivity behavior．