Six new biodegradable phosphate carbonate copolymers were synthesized by the polycondensation of bisphenol A

phosgene

and ethyl phosphorodichloridate or phenyl phosphorodichloridate.The copolymers obtained were characterized by IR

1H-NMR

and elemental analysis.The thermal property

n of copolymers were measured.The in vitro degradation of copolymers was studied in pH 7.4 phosphate buffer solution at 37℃ and in the presence of ribonuclease or alkalic phosphatase.The in vitro drug release of the copolymer loading 5-Fu was also investigated.