可注射水凝胶及其在再生医学领域的应用

冯茜; 张琨雨; 李睿; 边黎明

doi:10.11777/j.issn1000-3304.2020.20126

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可注射水凝胶及其在再生医学领域的应用

专论 | 更新时间：2021-05-15

- 可注射水凝胶及其在再生医学领域的应用
- Injectable Hydrogels for Regenerative Medicine
- 高分子学报 2021年52卷第1期页码：1-15
- 作者机构：
  
  1.香港中文大学生物医学工程学系生物材料与干细胞组织工程实验室　香港 999077
  2.重庆大学生物工程学院　重庆 400044
  3.Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21210, USA
  4.Applied Micro-Bioengineering Laboratory, Tandon School of Engineering, New York University, New York, NY 11201, USA
- 作者简介：
  
  [ "边黎明，男，1978年生. 香港中文大学生物医学工程系长聘副教授、博士生导师. 2009年博士毕业于哥伦比亚大学生物医学工程系，随后在宾夕法尼亚大学生物工程系进行博士后研究. 2012年夏加入香港中文大学. 主要研究方向为生物支架材料及纳米生物材料的设计及其在干细胞组织工程方面的应用，具体的研究方向包括仿生生物材料的设计开发，细胞微环境信息对干细胞行为的影响，多功能水凝胶的设计，纳米结构用于生物配体微观呈递，干细胞组织工程等" ]
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2020.20126
  中图分类号：
- 纸质出版日期：2021-1-3，
  
  网络出版日期：2020-9-7，
  
  收稿日期：2020-5-18，
  
  修回日期：2020-7-6，
扫描看全文
冯茜, 张琨雨, 李睿, 边黎明. 可注射水凝胶及其在再生医学领域的应用[J]. 高分子学报, 2021,52(1):1-15.

Qian Feng, Kun-yu Zhang, Rui Li, Li-ming Bian. Injectable Hydrogels for Regenerative Medicine[J]. Acta Polymerica Sinica, 2021,52(1):1-15.
冯茜, 张琨雨, 李睿, 边黎明. 可注射水凝胶及其在再生医学领域的应用[J]. 高分子学报, 2021,52(1):1-15. DOI： 10.11777/j.issn1000-3304.2020.20126.

Qian Feng, Kun-yu Zhang, Rui Li, Li-ming Bian. Injectable Hydrogels for Regenerative Medicine[J]. Acta Polymerica Sinica, 2021,52(1):1-15. DOI： 10.11777/j.issn1000-3304.2020.20126.

摘要

近年来，由工程生物材料制成的可注射治疗剂正变得越来越流行，并推动传统的临床实践走向微创化. 可注射水凝胶由于其可调控的物理及化学特性、可控的降解性能、高含水量以及在微创方式下实现递送的能力，在组织工程和药物递送领域中变得越来越重要. 研究者们已开发出例如原位交联水凝胶、大孔水凝胶、水凝胶微粒、动态交联水凝胶等一系列性能独特的可注射水凝胶. 通过调控水凝胶的固含量和交联密度，并引入适当的共价或非共价相互作用，例如静电相互作用、疏水相互作用等，这些水凝胶可在注射过程中实现生物活性分子的递送 . 同时，可注射水凝胶亦可用于细胞的递送，提供细胞培养所需的三维环境，并通过调控力学性能、化学修饰、生物功能化修饰等手段调控细胞黏附、增殖、分化等行为. 本文旨在回顾近年来可注射水凝胶的设计和制备的相关进展，以及其在再生医学中的应用，并对该领域存在的挑战和潜力进行了展望.

Abstract

Injectable therapeutics enabled by engineered biomaterials are becoming increasingly popular

transforming traditional clinical practice to become less invasive and more effective. Compared with traditional biomaterials

injectable biomaterials allow for more precise implantation into deeply enclosed anatomical locations and for the repair of irregularly shaped lesions

demonstrating great translational potential. Injectable hydrogels have become increasingly important in the fields of drug delivery

tissue engineering and regenerative medicine due to their tunable physical and chemical properties

controllable degradation

biomimetic water content

and the ability to achieve delivery in a minimally invasive manner. Researchers have developed a series of injectable hydrogels with unique properties through

in situ

gelation

macroporous hydrogels

microgels

and shear thinning. Importantly

these hydrogels can be used to achieve the delivery of bioactive molecules and cells during the injection process and provide the three-dimensional microenvironment required for cell culture. Rationale modifications of the hydrogel biophysical and biochemical properties enable precise regulation on cellular behaviors such as adhesion

proliferation

and differentiation. This article aims to review the recent advances in the design and preparation of injectable hydrogels and their applications in regenerative medicine and the key challenges to be addressed in future research work.

关键词

可注射水凝胶药物递送生物活性细胞培养临床应用

Keywords

InjectabilityHydrogelDrug deliveryBiological activityCell cultureClinical application

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