活性氧响应含碲高分子

潘烁炯; 许华平

doi:10.11777/j.issn1000-3304.2021.21058

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活性氧响应含碲高分子

专论 | 更新时间：2022-09-30

- 活性氧响应含碲高分子
- ROS-responsive Tellurium-containing Polymers
- 高分子学报 2021年52卷第8期页码：857-866
- 作者机构：
  
  清华大学化学系北京 100084
- 作者简介：
  
  [ "许华平，男，1978年生. 清华大学化学系教授. 2001和2006年分别在吉林大学化学学院获得学士和博士学位，导师为张希院士. 2004年4月~2005年3月，在比利时鲁汶大学交流学习1年. 2006年8月~2008年7月在荷兰Twente大学从事博士后研究. 2008年7月在清华大学化学系工作，2014年起为清华大学化学系教授. 2014年获国家自然科学基金委“杰出青年科学基金”资助. 2017年起担任美国化学会《ACS Biomaterials Science & Engineering》副主编. 任北京市化学会副秘书长、中国化学会化学教育学科委员会副主任委员、青年工作者委员会委员. 主要研究方向为含硒高分子." ]
- 基金信息：
  
  国家自然科学基金(基金号 ┣21734006);21821001┫
- DOI：10.11777/j.issn1000-3304.2021.21058
  中图分类号：
- 纸质出版日期：2021-08-20，
  
  网络出版日期：2021-05-24，
  
  收稿日期：2021-02-26，
  
  修回日期：2021-03-12，
扫描看全文
潘烁炯,许华平.活性氧响应含碲高分子[J].高分子学报,2021,52(08):857-866.

Pan Shuo-jiong,Hua-ping Xu.ROS-responsive Tellurium-containing Polymers[J].ACTA POLYMERICA SINICA,2021,52(08):857-866.
潘烁炯,许华平.活性氧响应含碲高分子[J].高分子学报,2021,52(08):857-866. DOI： 10.11777/j.issn1000-3304.2021.21058.

Pan Shuo-jiong,Hua-ping Xu.ROS-responsive Tellurium-containing Polymers[J].ACTA POLYMERICA SINICA,2021,52(08):857-866. DOI： 10.11777/j.issn1000-3304.2021.21058.

摘要

刺激响应性高分子是指在周围物理或者化学环境发生较小改变时，其结构和性质可以发生响应性改变的一类高分子. 我们课题组近年来系统地研究了一系列具有活性氧(ROS)响应性的含碲高分子以及其在药物递送领域中的应用. 本文从碲元素和硒元素的氧化响应性差异出发，探究了碲醚结构对活性氧灵敏的响应性. 随后研究了含碲高分子在药物递送领域，特别是在递送铂类药物中的应用，例如：主链含碲高分子可以同时包载顺铂和吲哚菁绿实现癌症化疗和光动力治疗的结合，侧链含碲/铂高分子可以实现癌症化疗和放疗的结合. 此外，碲/铂组装体还可以通过活性氧和配位双重响应，实现药物的可控释放.

Abstract

Stimuli-responsive polymers are defined as polymers whose structure and properties can be changed in response to minor changes in the surrounding physical or chemical environment and have become increasingly attractive as biomaterials. Reactive oxygen species (ROS) are a series of chemically reactive oxygen-containing molecules

which play an indispensable physiological role in cell signal transduction

acting as secondary messengers. It has been suggested that ROS levels in the cancer cells are much higher than those in the normal cells

and thus

ROS have been selected as a starting point or target for cancer therapy. Tellurium belongs to the chalcogen along with sulfur and selenium. Compared to sulfur and selenium

the relatively large atomic size and low electronegativity of tellurium give it many unique properties

such as redox sensitivity and coordination ability. In recent years

our research group pioneered in the research of ROS-responsive tellurium-containing polymers and their application in drug delivery. The work presented in this feature article

starting from the difference of oxidation responsiveness of tellurium and selenium

explored the ultra-sensitive ROS-response of tellurides. Then we studied the application of tellurium-containing polymers in drug delivery

focusing on the delivery of platinum drugs. For example

polymers with tellurium in the main chain can simultaneously deliver Cisplatin and indocyanine green to achieve a combination of cancer chemotherapy and photodynamic therapy

while side-chain tellurium/platinum-containing polymer can realize a combination of cancer chemotherapy and radiotherapy. Besides

the tellurium/platinum assembly can achieve controlled drug release through a dual response mechanism of ROS and coordination. Finally

we put forward the prospect of the development of tellurium-containing polymers

such as the development of controllable synthesis of tellurium-containing polymers based on chain polymerization

the development of tellurium-containing polymers and tellurium/platinum-containing assembly with different topological structures

and the exploration of the long-term toxicity of tellurium-containing molecules in biological applications.

关键词

碲活性氧响应配位响应药物递送

Keywords

TelluriumROS responseCoordination responseDrug delivery

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