诱导配体：蛋白质组装新策略

张智; 陈国颂; 江明

doi:10.11777/j.issn1000-3304.2021.21059

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诱导配体：蛋白质组装新策略

专论 | 更新时间：2022-09-30

- 诱导配体：蛋白质组装新策略
- Inducing Ligand Strategy: A New Strategy for Protein Assembly
- 高分子学报 2021年52卷第8期页码：867-883
- 作者机构：
  
  聚合物分子工程国家重点实验室复旦大学高分子科学系上海 200438
- 作者简介：
  
  [ "陈国颂，女，1979年生. 1997~2006年于南开大学化学系获得学士、博士学位；2006~2009年在美国爱荷华州立大学从事博士后研究；2009~2011年复旦大学高分子科学系讲师，2011~2014年复旦大学高分子科学系副教授. 2014年至今，复旦大学高分子科学系教授. 现任中国化学会青年化学工作者委员会委员(2015至今)；中国化学会高分子学科委员会委员(2018至今)；《ACS Macro Letters》副主编(2018至今)；中国化学会糖化学专业委员会委员(2019至今)；中国生物材料学会生物医用高分子材料分会委员(2019至今)；英国皇家化学会会士(2017至今). 主要从事蛋白质组装，基于糖的大分子组装体的免疫学功能，糖化学反应及超分子化学驱动的大分子组装等方面的研究." ]
- 基金信息：
  
  国家自然科学基金(基金号51721002;21861132012;91527305)
- DOI：10.11777/j.issn1000-3304.2021.21059
  中图分类号：
- 纸质出版日期：2021-08-20，
  
  网络出版日期：2021-06-30，
  
  收稿日期：2021-03-01，
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张智,陈国颂,江明.诱导配体：蛋白质组装新策略[J].高分子学报,2021,52(08):867-883.

Zhang Zhi,Chen Guo-song,Jiang Ming.Inducing Ligand Strategy: A New Strategy for Protein Assembly[J].ACTA POLYMERICA SINICA,2021,52(08):867-883.
张智,陈国颂,江明.诱导配体：蛋白质组装新策略[J].高分子学报,2021,52(08):867-883. DOI： 10.11777/j.issn1000-3304.2021.21059.

Zhang Zhi,Chen Guo-song,Jiang Ming.Inducing Ligand Strategy: A New Strategy for Protein Assembly[J].ACTA POLYMERICA SINICA,2021,52(08):867-883. DOI： 10.11777/j.issn1000-3304.2021.21059.

摘要

近年来，分子自组装的研究特别关注应用复杂组装基元模拟体内复杂的生命过程. 其中，利用蛋白质作为组装基元构筑组装体的相关研究有助于进一步了解生命相关的自组装，并进一步揭示生命过程的调控机制. 然而，由于蛋白质组装基元自身的结构复杂性和构象多样性等特点，具有规则结构的人工蛋白质组装体仍然难以构建. 本文将回顾和总结本课题组近年来所提出的诱导配体蛋白质组装新策略. 首先简要叙述文献中蛋白质组装方向的研究进展，继而介绍诱导配体策略产生的背景和主要思路，重点讨论利用诱导配体策略获得的蛋白质组装体的结构、形貌及功能，最后展望该策略的发展前景.

Abstract

In recent years

molecular self-assembly has been moving into employing more complex building blocks to emulate the complex life processes in nature. Among them

progress made in using proteins as the building blocks to construct assemblies could inspire us with a better understanding of the life-related self-assembly processes and ultimately endows us with the wisdom to design functional proteinaceous material comparable to nature. However

due to the intrinsic complexity and conformation variability of protein building blocks

artificial protein assemblies with well-defined structure have been hard to construct. Herein

this article reviews the inducing ligand strategy

which was a new strategy proposed by our group to construct protein assemblies with well-defined structure. We first introduce the research progress of the protein assembly in the literature. Then we discuss the discovery of the inducing ligand strategy

the structure

morphologies and functions of the various protein assemblies obtained

via

this strategy. By using this strategy

various assembled structures with precise protein packing including 1D nanofibers

2D nanosheets and 3D crystals have been developed. Among those

the most attractive one could be the helical microtubule structures obtained by using SBA and inducing ligand. Meanwhile

the possible mechanism of this protein assembly strategy has been discussed. Finally

the inducing ligand strategy is prospected.

关键词

蛋白组装自组装策略有序形貌精准调控纳米材料

Keywords

Protein assemblySelf-assembly strategyOrdered morphologyPrecise controlNanomaterials

references

Philp D, Stoddart J F. Angew Chem Int Ed, 1996, 35(11): 1154-1196. doi:10.1002/anie.199611541http://dx.doi.org/10.1002/anie.199611541

Whitesides G M, Grzybowski B. Science, 2002, 295(5564): 2418-2421. doi:10.1126/science.1070821http://dx.doi.org/10.1126/science.1070821

Whitesides G M, Mathias J P, Seto C T. Science, 1991, 254(5036): 1312-1319. doi:10.1126/science.1962191http://dx.doi.org/10.1126/science.1962191

Service R F. Science, 2005, 309(5731): 95. doi:10.1126/science.309.5731.95http://dx.doi.org/10.1126/science.309.5731.95

Kennedy D, Norman C. Science, 2005, 309(5731): 75. doi:10.1126/science.309.5731.75http://dx.doi.org/10.1126/science.309.5731.75

Yao H, Song Y, Chen Y, Wu N, Xu J, Sun C, Zhang J, Weng T, Zhang Z, Wu Z, Cheng L, Shi D, Lu X, Lei J, Crispin M, Shi Y, Li L, Li S. Cell, 2020, 183(3): 730-738. doi:10.1016/j.cell.2020.09.018http://dx.doi.org/10.1016/j.cell.2020.09.018

Dautant A, Meyer J B, Yariv J, Sweet R, Frolow F. Acta Crystallogr Sect D: Biol Crystallogr, 1998, 54(1): 16-24. doi:10.1107/s0907444997006811http://dx.doi.org/10.1107/s0907444997006811

Li H, DeRosier D J, Nicholson W V, Nogales E, Downing K H. Structure, 2002, 10(10): 1317-1328. doi:10.1016/s0969-2126(02)00827-4http://dx.doi.org/10.1016/s0969-2126(02)00827-4

Scheuring S, Stahlberg H, Chami M, Houssin C, Rigaud J L, Engel A. Mol Microbiol, 2002, 44(3): 675-684. doi:10.1046/j.1365-2958.2002.02864.xhttp://dx.doi.org/10.1046/j.1365-2958.2002.02864.x

Walls A C, Fiala B, Schafer A, Wrenn S, Pham M N, Murphy M, Tse L V, Shehata L, O'Connor M A, Chen C, Navarro M J, Miranda M C, Pettie D, Ravichandran R, Kraft J C, Ogohara C, Palser A, Chalk S, Lee E, Guerriero K, Kepl E, Chow C M, Sydeman C, Hodge E A, Brown B, Fuller J T, Dinnon K H, Gralinski L E, Leist S R, Gully K L, Lewis T B, Guttman M, Chu H Y, Lee K K, Fuller D H, Baric R S, Kellam P, Carter L, Pepper M, Sheahan T P, Veesler D, King N P. Cell, 2020, 183(5): 1367-1382

Malay A D, Miyazaki N, Biela A, Chakraborti S, Heddle J G. Nature, 2019, 569(7756): 438-442. doi:10.1038/s41586-019-1185-4http://dx.doi.org/10.1038/s41586-019-1185-4

Yang G, Zhang X, Kochovski Z, Zhang Y, Dai B, Sakai F, Jiang L, Lu Y, Ballauff M, Li X, Liu C, Chen G, Jiang M. J Am Chem Soc, 2016, 138(6): 1932-1937. doi:10.1021/jacs.5b11733http://dx.doi.org/10.1021/jacs.5b11733

Liu R, Kochovski Z, Li L, Yin Y, Yang J, Yang G, Tao G, Xu A, Zhang E, Ding H, Lu Y, Chen G, Jiang M. Angew Chem Int Ed, 2020, 59(24): 9617-9623. doi:10.1002/anie.202000771http://dx.doi.org/10.1002/anie.202000771

Sun H, Li Y, Yu S, Liu J. Front Bioeng Biotechnol, 2020, 8(295): 1-9

Luo Q, Hou C, Bai Y, Wang R, Liu J. Chem Rev, 2016, 116(22): 13571-13632. doi:10.1021/acs.chemrev.6b00228http://dx.doi.org/10.1021/acs.chemrev.6b00228

Yang Tingting(杨婷婷), Da Xiaodi(达晓娣), Zhang Wenbin(张文彬). Acta Polymerica Sinica(高分子学报), 2020, 51(8): 804-816. doi:10.11777/j.issn1000-3304.2020.20065http://dx.doi.org/10.11777/j.issn1000-3304.2020.20065

Padilla J E, Colovos C, Yeates T O. Proc Natl Acad Sci USA, 2001, 98(5): 2217-2221. doi:10.1073/pnas.041614998http://dx.doi.org/10.1073/pnas.041614998

Lai Y, Reading E, Hura G L, Tsai K, Laganowsky A, Asturias F J, Tainer J A, Robinson C V, Yeates T O. Nat Chem, 2014, 6(12): 1065-1071. doi:10.1038/nchem.2107http://dx.doi.org/10.1038/nchem.2107

Lai Y T, Cascio D, Yeates T O. Science, 2012, 336(6085): 1129-1129. doi:10.1126/science.1219351http://dx.doi.org/10.1126/science.1219351

Laniado J, Yeates T O. Proc Natl Acad Sci USA, 2020, 117(50): 31817-31823. doi:10.1073/pnas.2015183117http://dx.doi.org/10.1073/pnas.2015183117

Das R, Baker D. Annu Rev Biochem, 2008, 77: 363-382. doi:10.1146/annurev.biochem.77.062906.171838http://dx.doi.org/10.1146/annurev.biochem.77.062906.171838

Leaver-Fay A, Tyka M, Lewis S M, Lange O F, Bradley P. Methods Enzymol, 2011, 487(11): 545-574

Leman J K, Weitzner B D, Lewis S M, Adolf-Bryfogle J, Alam N, Alford R F, Aprahamian M, Baker D, Barlow K A, Barth P, Basanta B, Bender B J, Blacklock K, Bonet J, Boyken S E, Bradley P, Bystroff C, Conway P, Cooper S, Correia B E, Coventry B, Das R, De J, Rene M, DiMaio F, Dsilva L, Dunbrack R, Ford A S, Frenz B, Fu D Y, Geniesse C, Goldschmidt L, Gowthaman R, Gray J J, Gront D, Guffy S, Horowitz S, Huang P, Huber T, Jacobs T M, Jeliazkov J R, Johnson D K, Kappel K, Karanicolas J, Khakzad H, Khar K R, Khare S D, Khatib F, Khramushin A, King I C, Kleffner R, Koepnick B, Kortemme T, Kuenze G, Kuhlman B, Kuroda D, Labonte J W, Lai J K, Lapidoth G, Leaver-Fay A, Lindert S, Linsky T, London N, Lubin J H, Lyskov S, Maguire J, Malmstroem L, Marcos E, Marcu O, Marze N A, Meiler J, Moretti R, Mulligan V K, Nerli S, Norn C, O'Conchuir S, Ollikainen N, Ovchinnikov S, Pacella M S, Pan X, Park H, Pavlovicz R E, Pethe M, Pierce B G, Pilla K B, Raveh B, Renfrew P D, Burman S R, Rubenstein A, Sauer M F, Scheck A, Schief W, Schueler-Furman O, Sedan Y, Sevy A M, Sgourakis N G, Shi L, Siegel J B, Silva D, Smith S, Song Y, Stein A, Szegedy M, Teets F D, Thyme S B, Wang R, Watkins A, Zimmerman L, Bonneau R. Nat Methods, 2020, 17(7): 665-680

King N P, Bale J B, Sheffler W, McNamara D E, Gonen S, Gonen T, Yeates T O, Baker D. Nature, 2014, 510(7503): 103-108. doi:10.1038/nature13404http://dx.doi.org/10.1038/nature13404

Bale J B, Gonen S, Liu Y, Sheffler W, Ellis D, Thomas C, Cascio D, Yeates T O, Gonen T, King N P, Baker D. Science, 2016, 353(6297): 389-394. doi:10.1126/science.aaf8818http://dx.doi.org/10.1126/science.aaf8818

Hsia Y, Bale J B, Gonen S, Shi D, Sheffler W, Fong K K, Nattermann U, Xu C, Huang P, Ravichandran R, Yi S, Davis T N, Gonen T, King N P, Baker D. Nature, 2016, 535(7610): 136-139. doi:10.1038/nature18010http://dx.doi.org/10.1038/nature18010

Brouwer P J M, Antanasijevic A, Berndsen Z, Yasmeen A, Fiala B, Bijl T P, Bontjer I, Bale J B, Sheffler W, Allen J D, Schorcht A, Burgers J A, Camacho M, Ellis D, Cottrell C A, Behrens A, Catalano M, Del M I, Ketas T J, LaBranche C, van G M J, Sliepen K, Stewart L J, Crispin M, Montefiori D C, Baker D, Moore J P, Klasse P J, Ward A B, King N P, Sanders R W. Nat Commun, 2019, 10(1): 4272-4272

Marcandalli J, Fiala B, Ols S, Perotti M, Devander W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, Sallusto F, Lee K K, Veesler D, Correnti C E, Stewart L J, Baker D, Lore K, Perez L, King N P. Cell, 2019, 176(6): 1420-1431

Boyoglu-Barnum S, Ellis D, Gillespie R A, Hutchinson G B, Park Y, Moin S M, Acton O J, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson M J, Kephart S, Ataca S, Vaile J R, Ueda G, Crank M C, Stewart L, Lee K K, Guttman M, Baker D, Mascola J R, Veesler D, Graham B S, King N P, Kanekiyo M. Nature, 2021, 592: 623-628

Kanekiyo M, Ellis D, King N P. J Infect Dis, 2019, 219(Suppl_1): S88-S96. doi:10.1093/infdis/jiy745http://dx.doi.org/10.1093/infdis/jiy745

Kanekiyo M, Graham B S. CSH Perspect Med, 2020: a038448. doi:10.1101/cshperspect.a038448http://dx.doi.org/10.1101/cshperspect.a038448

Kaufmann K W, Lemmon G H, DeLuca S L, Sheehan J H, Meiler J. Biochemistry-US, 2010, 49(14): 2987-2998. doi:10.1021/bi902153ghttp://dx.doi.org/10.1021/bi902153g

Rohl C A, Strauss C E, Misura K M, Baker D. Methods Enzymol, 2004, 383: 66-93

Yang C, Sesterhenn F, Bonet J, van A A, Scheller L, Abriata L A, Cramer J T, Wen X, Rosset S, Georgeon S, Jardetzky T, Kreys T, Fussenegger M, Merkx M, Correia B E. Nat Chem Biol, 2021, 17(4): 492-500. doi:10.1038/s41589-020-00699-xhttp://dx.doi.org/10.1038/s41589-020-00699-x

Ben-Sasson A J, Watson J L, Sheffler W, Johnson M C, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek A A, Jarrett S M, Blacklow S C, Kaminski C F, Hura G L, De Yoreo J J, Kollman J M, Ruohola-Baker H, Derivery E, Baker D. Nature, 2021, 589(7842): 468-473. doi:10.1038/s41586-020-03120-8http://dx.doi.org/10.1038/s41586-020-03120-8

Zou J, Yin J, Fang L, Yang M, Zhang P. J Chem Inf Model, 2020, 60(12): 5794-5802. doi:10.1021/acs.jcim.0c00679http://dx.doi.org/10.1021/acs.jcim.0c00679

Smith S T, Meiler J. Plos One, 2020, 15(10): e0240450. doi:10.1371/journal.pone.0240450http://dx.doi.org/10.1371/journal.pone.0240450

Service R F. Science, 2020, 370(6521): 1144-1145. doi:10.1126/science.370.6521.1144http://dx.doi.org/10.1126/science.370.6521.1144

Levinthal C. Mossbauer Spectroscopy in Biological Systems, 1969, 67: 22-24

Bai Y, Luo Q, Liu J. Chem Soc Rev, 2016, 45(10): 2756-2767. doi:10.1039/c6cs00004ehttp://dx.doi.org/10.1039/c6cs00004e

van Dun S, Ottmann C, Milroy L G, Brunsveld L. J Am Chem Soc, 2017, 139(40): 13960-13968. doi:10.1021/jacs.7b01979http://dx.doi.org/10.1021/jacs.7b01979

Fegan A, White B, Carlson J C T, Wagner C R. Chem Rev, 2010, 110(6): 3315-3336. doi:10.1021/cr8002888http://dx.doi.org/10.1021/cr8002888

Yang G, Wu L, Chen G, Jiang M. Chem Commun, 2016, 52(70): 10595-10605. doi:10.1039/c6cc04190fhttp://dx.doi.org/10.1039/c6cc04190f

Churchfield L A, Tezcan F A. Acc Chem Res, 2019, 52(2): 345-355. doi:10.1021/acs.accounts.8b00617http://dx.doi.org/10.1021/acs.accounts.8b00617

Salgado E N, Radford R J, Tezcan F A. Acc Chem Res, 2010, 43(5): 661-672. doi:10.1021/ar900273thttp://dx.doi.org/10.1021/ar900273t

Sontz P A, Bailey J B, Ahn S, Tezcan F A. J Am Chem Soc, 2015, 137(36): 11598-11601. doi:10.1021/jacs.5b07463http://dx.doi.org/10.1021/jacs.5b07463

Fujita D, Fujita M. ACS Central Sci, 2015, 1(7): 352-353. doi:10.1021/acscentsci.5b00315http://dx.doi.org/10.1021/acscentsci.5b00315

Bailey J B, Tezcan F A. J Am Chem Soc, 2020, 142(41): 17265-17270. doi:10.1021/jacs.0c07835http://dx.doi.org/10.1021/jacs.0c07835

Bailey J B, Zhang L, Chiong J A, Ahn S, Tezcan F A. J Am Chem Soc, 2017, 139(24): 8160-8166. doi:10.1021/jacs.7b01202http://dx.doi.org/10.1021/jacs.7b01202

Sim S, Aida T. Acc Chem Res, 2017, 50(3): 492-497. doi:10.1021/acs.accounts.6b00495http://dx.doi.org/10.1021/acs.accounts.6b00495

Biswas S, Kinbara K, Niwa T, Taguchi H, Ishii N, Watanabe S, Miyata K, Kataoka K, Aida T. Nat Chem, 2013, 5(7): 613-620. doi:10.1038/nchem.1681http://dx.doi.org/10.1038/nchem.1681

Sim S, Niwa T, Taguchi H, Aida T. J Am Chem Soc, 2016, 138(35): 11152-11155. doi:10.1021/jacs.6b07925http://dx.doi.org/10.1021/jacs.6b07925

Sim S, Miyajima D, Niwa T, Taguchi H, Aida T. J Am Chem Soc, 2015, 137(14): 4658-4661. doi:10.1021/jacs.5b02144http://dx.doi.org/10.1021/jacs.5b02144

Sun H, Zhang X, Miao L, Zhao L, Luo Q, Xu J, Liu J. ACS Nano, 2015, 10(1): 421-428

Sun H, Miao L, Li J, Fu S, An G, Si C, Dong Z, Luo Q, Yu S, Xu J, Liu J. ACS Nano, 2015, 9(5): 5461-5469. doi:10.1021/acsnano.5b01311http://dx.doi.org/10.1021/acsnano.5b01311

Miao L, Han J, Zhang H, Zhao L, Si C, Zhang X, Hou C, Luo Q, Xu J, Liu J. ACS Nano, 2014, 8(4): 3743-3751. doi:10.1021/nn500414uhttp://dx.doi.org/10.1021/nn500414u

Bai Y, Luo Q, Zhang W, Miao L, Xu J, Li H, Liu J. J Am Chem Soc, 2013, 135(30): 10966-10969. doi:10.1021/ja405519shttp://dx.doi.org/10.1021/ja405519s

Hou C, Li J, Zhao L, Zhang W, Luo Q, Dong Z, Xu J, Liu J. Angew Chem Int Ed, 2013, 52(21): 5590-5593. doi:10.1002/anie.201300692http://dx.doi.org/10.1002/anie.201300692

McMillan J R, Hayes O G, Winegar P H, Mirkin C A. Acc Chem Res, 2019, 52(7): 1939-1948. doi:10.1021/acs.accounts.9b00165http://dx.doi.org/10.1021/acs.accounts.9b00165

Stephanopoulos N. Chem-US, 2020, 6(2): 364-405. doi:10.1016/j.chempr.2020.01.012http://dx.doi.org/10.1016/j.chempr.2020.01.012

Liu R, Hudalla G A. Molecules, 2019, 24(8): 1-21. doi:10.3390/molecules24081450http://dx.doi.org/10.3390/molecules24081450

van Rijn P. Polymers-Basel, 2013, 5(2): 576-599. doi:10.3390/polym5020576http://dx.doi.org/10.3390/polym5020576

Oohora K, Onoda A, Hayashi T. Chem Commun, 2012, 48(96): 11714. doi:10.1039/c2cc36376chttp://dx.doi.org/10.1039/c2cc36376c

Oohora K, Hayashi T. Curr Opin Chem Biol, 2014, 19: 154-161. doi:10.1016/j.cbpa.2014.02.014http://dx.doi.org/10.1016/j.cbpa.2014.02.014

Kitagishi H, Oohora K, Yamaguchi H, Sato H, Matsuo T, Harada A, Hayashi T. J Am Chem Soc, 2007, 129(34): 10326-10327. doi:10.1021/ja073295qhttp://dx.doi.org/10.1021/ja073295q

Kitagishi H, Kakikura Y, Yamaguchi H, Oohora K, Harada A, Hayashi T. Angew Chem Int Ed, 2008, 121(7): 1297-1300

Oohora K, Kajihara R, Fujimaki N, Uchihashi T, Hayashi T. Chem Commun, 2019, 55(11): 1544-1547. doi:10.1039/c8cc09314hhttp://dx.doi.org/10.1039/c8cc09314h

Muller W, Ringsdorf H, Rump E, Wildburg G, Zhang X, Angermaier L, Knoll W, Liley M, Spinke J. Science, 1993, 262(5140): 1706-1708. doi:10.1126/science.8259513http://dx.doi.org/10.1126/science.8259513

Dotan N, Arad D, Frolow F, Freeman A. Angew Chem Int Ed, 1999, 38(16): 2363-2366. doi:10.1002/(sici)1521-3773(19990816)38:16<2363::aid-anie2363>3.0.co;2-dhttp://dx.doi.org/10.1002/(sici)1521-3773(19990816)38:16<2363::aid-anie2363>3.0.co;2-d

Lameignere E, Shiao T C, Roy R, Wimmerova M, Dubreuil F, Varrot A, Imberty A. Glycobiology, 2010, 20(1): 87-98. doi:10.1093/glycob/cwp151http://dx.doi.org/10.1093/glycob/cwp151

Sicard D, Cecioni S, Iazykov M, Chevolot Y, Matthews S E, Praly J, Souteyrand E, Imberty A, Vidal S, Phaner-Goutorbe M. Chem Commun, 2011, 47(33): 9483-9485. doi:10.1039/c1cc13097hhttp://dx.doi.org/10.1039/c1cc13097h

Wang J, Hang Y, Hua J. Sensor Actuat B - Chem, 2019(282): 232-242. doi:10.1016/j.snb.2018.10.091http://dx.doi.org/10.1016/j.snb.2018.10.091

Ahmad N, Gabius H, Andre S, Kaltner H, Sabesan S, Roy R, Liu B, Macaluso F, Brewer C. J Biol Chem, 2004, 279(12): 10841-10847. doi:10.1074/jbc.m312834200http://dx.doi.org/10.1074/jbc.m312834200

Wei K, Li J, Chen G, Jiang M. ACS Macro Lett, 2013, 2(3): 278-283. doi:10.1021/mz400036thttp://dx.doi.org/10.1021/mz400036t

Sakai F, Yang G, Weiss M S, Liu Y, Chen G, Jiang M. Nat Commun, 2014, 5(1): 4634. doi:10.1038/ncomms5634http://dx.doi.org/10.1038/ncomms5634

Hashizume Y, Inaka K, Furubayashi N, Kamo M, Takahashi S, Tanaka H. Crystals, 2020, 10(2): 1-21. doi:10.3390/cryst10020078http://dx.doi.org/10.3390/cryst10020078

Hu R, Yang G, Ding H M, Ma J, Ma Y Q, Gan J, Chen G. Ind Eng Chem Res, 2018, 57(19): 6726-6733. doi:10.1021/acs.iecr.8b00657http://dx.doi.org/10.1021/acs.iecr.8b00657

Gupta D, Bhattacharyya L, Fant J, Macaluso F, Sabesan S, Brewer C. Biochemistry-US, 1994, 33(18): 5614-5622. doi:10.1021/bi00184a600http://dx.doi.org/10.1021/bi00184a600

Dessen A, Gupta D, Sabesan S, Brewer C F, Sacchettini J C. Biochemistry-US, 1995, 34(15): 4933-4942. doi:10.1021/bi00015a004http://dx.doi.org/10.1021/bi00015a004

Olsen L R, Dessen A, Gupta D, Sabesan S, Sacchettini J C, Brewer C F. Biochemistry-US, 1997, 36(49): 15073-15080. doi:10.1021/bi971828+http://dx.doi.org/10.1021/bi971828+

Bhattacharyya L, Brewer C F. Eur J Biochem, 1989, 178(3): 721-726. doi:10.1111/j.1432-1033.1989.tb14503.xhttp://dx.doi.org/10.1111/j.1432-1033.1989.tb14503.x

Yang G, Ding H, Kochovski Z, Hu R, Lu Y, Ma Y, Chen G, Jiang M. Angew Chem Int Ed, 2017, 56(36): 10691-10695. doi:10.1002/anie.201703052http://dx.doi.org/10.1002/anie.201703052

Jordan M A, Wilson L. Nat Rev Cancer, 2004, 4(4): 253-265. doi:10.1038/nrc1317http://dx.doi.org/10.1038/nrc1317

Petrov A, Audette G F. WIREs Nanomed Nanobiotechnol, 2012, 4(5): 575-585. doi:10.1002/wnan.1180http://dx.doi.org/10.1002/wnan.1180

Qing Y, Tamagaki-Asahina H, Ionescu S A, Liu M D, Bayley H. Nat Nanotechnol, 2019, 14(12): 1-8. doi:10.1038/s41565-019-0579-7http://dx.doi.org/10.1038/s41565-019-0579-7

Brodin J D, Carr J R, Sontz P A, Tezcan F A. Proc Natl Acad Sci USA, 2014, 111(8): 2897-2902. doi:10.1073/pnas.1319866111http://dx.doi.org/10.1073/pnas.1319866111

Sendai T, Biswas S, Aida T. J Am Chem Soc, 2013, 135(31): 11509-11512. doi:10.1021/ja4060146http://dx.doi.org/10.1021/ja4060146

Ballister E R, Lai A H, Zuckermann R N, Cheng Y, Mougous J D. Proc Natl Acad Sci USA, 2008, 105(10): 3733-3738. doi:10.1073/pnas.0712247105http://dx.doi.org/10.1073/pnas.0712247105

Miranda F F, Iwasaki K, Akashi S, Sumitomo K, Kobayashi M, Yamashita I, Tame J R, Heddle J G. Small, 2009, 5(18): 2077-2084. doi:10.1002/smll.200990091http://dx.doi.org/10.1002/smll.200990091

Sui H, Downing K H. Structure, 2010, 18(8): 1022-1031. doi:10.1016/j.str.2010.05.010http://dx.doi.org/10.1016/j.str.2010.05.010

Li Z, Chen S, Gao C, Yang Z, Shih K, Kochovski Z, Yang G, Gou L, Nieh M, Jiang M, Zhang L, Chen G. J Am Chem Soc, 2019, 141(49): 19448-19457. doi:10.1021/jacs.9b10505http://dx.doi.org/10.1021/jacs.9b10505

Goodson H V, Jonasson E M. CSH Perspect Biol, 2018, 10(6): a022608. doi:10.1101/cshperspect.a022608http://dx.doi.org/10.1101/cshperspect.a022608

Yang G, Hu R, Ding H, Kochovski Z, Mei S, Lu Y, Ma Y, Chen G, Jiang M. Mat Chem Front, 2018, 2(9): 1642-1646. doi:10.1039/c8qm00245bhttp://dx.doi.org/10.1039/c8qm00245b

Yang G, Kochovski Z, Ji Z, Lu Y, Chen G, Jiang M. Chem Commun, 2016, 52(62): 9687-9690. doi:10.1039/c6cc04250chttp://dx.doi.org/10.1039/c6cc04250c

Sun D, Wu R, Li P, Yu L. J Mol Biol, 2020, 432(1): 160-169. doi:10.1016/j.jmb.2019.06.026http://dx.doi.org/10.1016/j.jmb.2019.06.026

Nguyen T K, Ueno T. Curr Opin Struc Biol, 2018, 51: 1-8. doi:10.1016/j.sbi.2017.12.005http://dx.doi.org/10.1016/j.sbi.2017.12.005

Tang T, An B, Huang Y, Vasikaran S, Wang Y, Jiang X, Lu T K, Zhong C. Nat Rev Mater, 2020, 6: 332-350

Csizmar C M, Petersburg J R, Wagner C R. Cell Chem Biol, 2018, 25(8): 931-940. doi:10.1016/j.chembiol.2018.05.009http://dx.doi.org/10.1016/j.chembiol.2018.05.009

Qi W, Zhang Y, Kochovski Z, Wang J, Lu Y, Chen G, Jiang M. Nano Res, 2018, 11(10): 5566-5572. doi:10.1007/s12274-018-2169-7http://dx.doi.org/10.1007/s12274-018-2169-7

Johannes L, Jacob R, Leffler H. J Cell Sci, 2018, 131(9): 1-9. doi:10.1242/jcs.208884http://dx.doi.org/10.1242/jcs.208884

Disney M D, Childs-Disney J L. Chem Biol, 2007, 14(10): 1095-1097. doi:10.1016/j.chembiol.2007.10.002http://dx.doi.org/10.1016/j.chembiol.2007.10.002

Hu Rongting(胡榕婷), Wang Jue(王珏), Yang Jing(杨静), Ding Yu(丁澦), Chen Guosong(陈国颂). Acta Polymerica Sinica(高分子学报), 2019, 50(2): 135-146. doi:10.11777/j.issn1000-3304.2019.18204http://dx.doi.org/10.11777/j.issn1000-3304.2019.18204

Xu M, Liu L, Yan Q. Angew Chem Int Ed, 2018, 57(18): 5029-5032. doi:10.1002/anie.201801081http://dx.doi.org/10.1002/anie.201801081

Ehrick J D, Deo S K, Browning T W, Bachas L G, Madou M J, Daunert S. Nat Mater, 2005, 4(4): 298-302. doi:10.1038/nmat1352http://dx.doi.org/10.1038/nmat1352

Liao X, Chen G, Jiang M. Polym Chem-UK, 2013, 4(6): 1733-1745. doi:10.1039/c2py20693ehttp://dx.doi.org/10.1039/c2py20693e

Li X, Tian R, Ji Y, Liu S, Jiang X, Li F, Luo Q, Hou C, Xu J, Liu J. ACS Macro Lett, 2021, 10(2): 307-311. doi:10.1021/acsmacrolett.0c00805http://dx.doi.org/10.1021/acsmacrolett.0c00805

Gao C, Chen G. Acc Chem Res, 2020, 53(4): 740-751. doi:10.1021/acs.accounts.9b00552http://dx.doi.org/10.1021/acs.accounts.9b00552

Chen G. Giant, 2020, 1: 100004. doi:10.1016/j.giant.2020.100004http://dx.doi.org/10.1016/j.giant.2020.100004

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