胱氨酸基聚氨基酸纳米材料的可控合成及其生物医学应用

杨佳臻; 邹昊洋; 丁建勋; 陈学思

doi:10.11777/j.issn1000-3304.2021.21115

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胱氨酸基聚氨基酸纳米材料的可控合成及其生物医学应用

综述 | 更新时间：2022-09-30

- 胱氨酸基聚氨基酸纳米材料的可控合成及其生物医学应用
- Controlled Synthesis and Biomedical Applications of Cystine-based Polypeptide Nanomaterials
- 高分子学报 2021年52卷第8期页码：960-977
- 作者机构：
  
  1.中国科学院长春应用化学研究所中国科学院生态环境高分子材料重点实验室长春 130022
  2.中国科学技术大学应用化学与工程学院合肥 230026
- 作者简介：
  
  [ "丁建勋，男，1986 年生. 中国科学院长春应用化学研究所项目研究员. 2007 年获得中国科学技术大学理学学士学位，2012 年获得中国科学院长春应用化学研究所理学博士学位.2017~2019 年赴哈佛医学院开展博士后研究. 入选吉林省拔尖创新人才(2015 年)、吉林省青年人才托举工程项目(2018 年)、中国科学院青年创新促进会会员(2019 年)、国家优秀青年科学基金项目(2020 年). 荣获中国科学院院长优秀奖(2012 年)、中国专利优秀奖(2013 年)、吉林省科技进步一等奖(2018 年)、中国化学会高分子青年学者奖(2019 年)等奖项. 主要研究方向为生物活性聚氨基酸的可控合成及其医学应用." ]
- 基金信息：
  
  国家自然科学基金(基金号 ┣52022095;51973216;51873207);51833010┫
- DOI：10.11777/j.issn1000-3304.2021.21115
  中图分类号：
- 纸质出版日期：2021-08-20，
  
  网络出版日期：2021-08-05，
  
  收稿日期：2021-04-21，
  
  修回日期：2021-06-01，
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杨佳臻,邹昊洋,丁建勋等.胱氨酸基聚氨基酸纳米材料的可控合成及其生物医学应用[J].高分子学报,2021,52(08):960-977.

Yang Jia-zhen,Zou Hao-yang,Ding Jian-xun,et al.Controlled Synthesis and Biomedical Applications of Cystine-based Polypeptide Nanomaterials[J].ACTA POLYMERICA SINICA,2021,52(08):960-977.
杨佳臻,邹昊洋,丁建勋等.胱氨酸基聚氨基酸纳米材料的可控合成及其生物医学应用[J].高分子学报,2021,52(08):960-977. DOI： 10.11777/j.issn1000-3304.2021.21115.

Yang Jia-zhen,Zou Hao-yang,Ding Jian-xun,et al.Controlled Synthesis and Biomedical Applications of Cystine-based Polypeptide Nanomaterials[J].ACTA POLYMERICA SINICA,2021,52(08):960-977. DOI： 10.11777/j.issn1000-3304.2021.21115.

摘要

聚氨基酸是一类以氨基酸及其衍生物为结构单元的高分子. 鉴于其多样性的结构单元、优异的生物安全性、便利的修饰性、敏感的生物响应性和独特的二级结构等优异的性能，聚氨基酸在生物医学领域的应用具有显著的优势. 胱氨酸是半胱氨酸通过二硫键连接的二聚体，可以通过环化反应合成为双官能化的胱氨酸

-内羧酸酐(Cys

NCA)单体. 通过Cys

NCA与单官能化的氨基酸

-内羧酸酐单体的开环聚合反应，可以可控合成一系列二硫键交联的具有多样性的化学结构、可调的粒径、优异的稳定性和敏感的生物响应性的聚氨基酸纳米材料，从而实现成像剂、生物活性分子等的可控递送. 本文基于本课题组的研究工作综述了单组分、双组分和多组分胱氨酸基聚氨基酸纳米材料的研究进展，并展望了其在临床应用中的机遇与挑战以及新的生物医学应用领域.

Abstract

Polypeptides are a kind of polymers with amino acids and their derivatives as structural units. Given their excellent properties

such as various structural units

excellent biosafety

facile modification

sensitive bioresponsiveness

and unique secondary structures

polypeptides have superior advantages for biomedical applications. Cystine is a dimer of cysteine linked by a disulfide bond

which can be synthesized into a bifunctional cysteine

-carboxylanhydride (Cys

NCA) monomer by cyclization reaction. Through the ring-opening polymerization of Cys

NCA and another monofunctional amino acid NCAs

a series of disulfide-crosslinked polypeptide nanomaterials could be controllably synthesized with diverse chemical structures

adjustable particle sizes

excellent stability

and biological responsiveness to achieve the controlled delivery of imaging agents and bioactive molecules. Based on the recent studies of our group

this review summarized the research progress of single-component

double-component

and multi-component cystine-based polypeptide nanomaterials. To be specific

the functions of single-component cystine-based polypeptide nanomaterials are limited. The double-component polypeptide nanomaterials

which are developed on the basis of single-component ones

show improved drug loading rates

expanded types of loading drugs

and a more stable nanostructures. In order to achieve a more exclusive function as a drug delivery platform

we expect to use the synergy and cascade action of different functionalized amino acids to produce multi-component polypeptide nanomaterials. The multi-component nanoplatform might provide reliable solutions for precision medicine. At last

their opportunities and challenges in clinical application and the new medical application fields were predicted.

关键词

胱氨酸聚氨基酸纳米材料可控合成功能化生物响应性

Keywords

CystinePolypeptideNanomaterialControlled synthesisFunctionalizationBioresponsiveness

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