基于多肽的药物递送系统研究进展

李怡静; 龚雪峰; 王冬; 杨洲; 曹晖; 王磊

doi:10.11777/j.issn1000-3304.2021.21369

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基于多肽的药物递送系统研究进展

综述 | 更新时间：2024-10-08

- 基于多肽的药物递送系统研究进展
- Recent Progress of Peptide-based Drug Delivery System
- 高分子学报 2022年53卷第5期页码：445-456
- 作者机构：
  
  1.北京科技大学材料科学与工程学院北京 100083
  2.中国科学院纳米科学卓越创新中心国家纳米科学中心北京 100190
- 作者简介：
  
  [ "曹晖，男，1977年生. 北京科技大学材料科学与工程学院教授. 2000年在吉林大学取得学士学位；2005年在吉林大学取得博士学位(硕博连读)，师从张万金教授. 2019~2020年在新加坡国立大学访问研究. 获国家科学技术奖技术发明二等奖1项(排名第二)、高等学校科学研究优秀成果奖(科学技术)自然科学一等奖1项(排名第二)、高等学校科学研究优秀成果奖(科学技术)技术发明一等奖1项(排名第二)，主要从事生物材料、液晶材料、纳米材料等功能材料的基础和应用研究." ]
  [ "王磊，男，1979年生. 2002年于东北师范大学获得理学学士学位；2008年于韩国全北国立大学高分子纳米工学科获得博士学位并继续做博士后研究，2009年回国入职北京科技大学，2012年加入国家纳米科学中心，现任研究员. 《Chinese Chemical Letters》青年编委. 曾获“Merck-青年科学家奖”，“纳米产业技术创新专业赛”决赛一等奖. 研究方向：过程仿生多肽基生物医用高分子材料，包括多肽分子设计、筛选和制备，仿生机理研究以及基于仿生多肽的“识别-捕获-治疗”策略在重大疾病诊疗中的应用研究." ]
- 基金信息：
  
  国家自然科学基金(基金号 51890891)
- DOI：10.11777/j.issn1000-3304.2021.21369
  中图分类号：
- 纸质出版日期：2022-05-20，
  
  网络出版日期：2022-03-21，
  
  收稿日期：2021-12-02，
  
  录用日期：2022-01-07
- 稿件说明：
移动端阅览
李怡静,龚雪峰,王冬等.基于多肽的药物递送系统研究进展[J].高分子学报,2022,53(05):445-456.

Li Yi-jing,Gong Xue-feng,Wang Dong,et al.Recent Progress of Peptide-based Drug Delivery System[J].ACTA POLYMERICA SINICA,2022,53(05):445-456.
李怡静,龚雪峰,王冬等.基于多肽的药物递送系统研究进展[J].高分子学报,2022,53(05):445-456. DOI： 10.11777/j.issn1000-3304.2021.21369.

Li Yi-jing,Gong Xue-feng,Wang Dong,et al.Recent Progress of Peptide-based Drug Delivery System[J].ACTA POLYMERICA SINICA,2022,53(05):445-456. DOI： 10.11777/j.issn1000-3304.2021.21369.

摘要

药物递送系统是将药物输送到药物作用靶点的系统，理想的递送系统可以提高药物作用效果并降低给药剂量和毒副作用. 本文综述了药物递送系统中的多肽类药物递送系统的研究进展. 多肽具有易合成、易代谢、免疫原性低、毒副作用低等优点，多肽支链上大量的官能团可以和药物偶联，是药物递送系统的重要发展方向. 本文从靶向肽、穿透肽、响应肽和组装肽四个方面介绍了多肽药物递送系统的原理和实例. 组装肽可以形成纳米结构，显著提升多肽药物递送系统的稳定性，可以实现长效释放. 组装肽体内原位调控进一步增加了多肽药物递送系统的智能型、精准性，展现出巨大的转化潜力.

Abstract

Drug delivery system is a system to deliver drugs to targets. An ideal delivery system can improve drug efficacy and reduce drug dosage

toxicity and side effects. This paper reviews the research progress of peptide-based drug delivery systems. Polypeptide (peptide) has the advantages of facile synthesis

easy metabolism

low immunogenicity

low toxicity and side effects. In addition

there are a large number of functional groups on the peptide branch chain

which can be coupled with drugs. Therefore

peptide-based drug delivery system has become an important development direction of drug delivery system

which is introduced from four aspects: targeting peptides

penetrating peptides

response peptides and assembling peptides with the examples and principles. Assembling peptides form nanostructures and enhance the stability of drug delivery system for long-term release.

In vivo

modulation of assembly behavior of peptides increased the intelligence and precise

showing great potential in clinical translation of drug delivery system.

关键词

靶向肽穿透肽响应肽组装肽药物递送

Keywords

Targeting peptidePenetrating peptideResponse peptideAssembling peptideDrug delivery system

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