聚合物微针药物经皮递送应用研究进展

曾志勇; 江国华; 刘天琦; 张雪雅; 孙延芳

doi:10.11777/j.issn1000-3304.2022.22001

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聚合物微针药物经皮递送应用研究进展

综述 | 更新时间：2024-10-08

- 聚合物微针药物经皮递送应用研究进展
- Progress of Polymer Microneedles on Transdermal Drug Delivery
- 高分子学报 2022年53卷第8期页码：876-893
- 作者机构：
  
  1.浙江理工大学，材料科学与工程学院，杭州 310018
  2.浙江理工大学，智能生物材料与功能纤维国际科技合作基地，杭州 310018
  3.浙江理工大学，浙江-毛里求斯生物医用材料与组织工程联合中心，杭州 310018
  4.浙江理工大学，生命科学与医药学院，杭州 310018
- 作者简介：
  
  [ "江国华男，1975年生. 2003~2006年浙江大学，获博士学位；2006~2008年在新加坡南洋理工大学和美国密歇根大学做博士后. 现任浙江理工大学材料科学与工程学院教授、博士生导师. 在国内外学术期刊上发表科研论文一百五十余篇. 主持多项国家、省部级科研项目，曾获浙江省151人才、浙江省中青年学科带头人等. 致力于生物高分子材料载体设计与药物递送，以及聚合物功能纳米纤维的研究工作.Email:ghjiang_cn@zstu.edu.cn" ]
- 基金信息：
  
  国家自然科学基金(基金号 51873194);浙江省自然科学基金(基金号 LY18E030006)
- DOI：10.11777/j.issn1000-3304.2022.22001
  中图分类号：
- 纸质出版日期：2022-08-20，
  
  网络出版日期：2022-05-11，
  
  收稿日期：2022-01-02，
  
  录用日期：2022-02-11
- 稿件说明：
移动端阅览
曾志勇,江国华,刘天琦等.聚合物微针药物经皮递送应用研究进展[J].高分子学报,2022,53(08):876-893.

Zeng Zhi-yong,Jiang Guo-hua,Liu Tian-qi,et al.Progress of Polymer Microneedles on Transdermal Drug Delivery[J].ACTA POLYMERICA SINICA,2022,53(08):876-893.
曾志勇,江国华,刘天琦等.聚合物微针药物经皮递送应用研究进展[J].高分子学报,2022,53(08):876-893. DOI： 10.11777/j.issn1000-3304.2022.22001.

Zeng Zhi-yong,Jiang Guo-hua,Liu Tian-qi,et al.Progress of Polymer Microneedles on Transdermal Drug Delivery[J].ACTA POLYMERICA SINICA,2022,53(08):876-893. DOI： 10.11777/j.issn1000-3304.2022.22001.

摘要

微针是一种新型的药物经皮递送技术，能穿透皮肤角质层，形成微孔通道，促进药物的渗透和吸收，在药物递送中有重要作用. 本文从微针的结构和功能特点，系统阐述了聚合物微针的结构和功能设计，以及制造聚合物微针的材料和方法、微针的给药方式；综述了微针经皮递送技术近年来在抗肿瘤、疫苗递送、血糖调控、组织液提取和检测，以及生物传感等领域中的研究进展，并对其优势及存在的问题进行分析，总结了微针技术发展需要解决的关键问题，展望了微针疫苗未来的发展方向.

Abstract

Microneedle (MNs) is a new technology for transdermal drug delivery

which can penetrate the stratum corneum to form micropore channels and promote the penetration and absorption of drugs. Based on the structure and function properties of MNs

the structure and function design of polymer MNs are systematically described in this review. And the materials and methods for the fabrication of polymer MNs and their drug administration are discussed as well. The recent progresses of MNs in anti-tumor

vaccine delivery

blood glucose regulation

tissue fluid extraction and detection are reviewed. The challenge of MNs technology is summarized and the future development trend of MNs is also prospected.

关键词

聚合物微针抗肿瘤疫苗递送血糖调控经皮给药

Keywords

Polymer microneedlesAnti-tumorVaccine deliveryBlood glucose regulationTransdermal drug delivery

references

Barry B W. Nat Biotechnol, 2004, 22: 165-167. doi:10.1038/nbt0204-165http://dx.doi.org/10.1038/nbt0204-165

Prausnitz M R. Adv Drug Delivery Rev, 2004, 56(5): 581-587. doi:10.1016/j.addr.2003.10.023http://dx.doi.org/10.1016/j.addr.2003.10.023

Singh P, Carrier A, Chen Y L, Lin S J, Wang J L, Cui S F, Zhang X. J Control Release, 2019, 315: 97-113. doi:10.1016/j.jconrel.2019.10.022http://dx.doi.org/10.1016/j.jconrel.2019.10.022

Kim Y C, Park J H, Prausnitz M R. Adv Drug Delivery Rev, 2012, 64(14): 1547-1568. doi:10.1016/j.addr.2012.04.005http://dx.doi.org/10.1016/j.addr.2012.04.005

Ma G J, Wu C G. J Control Release, 2017, 251: 11-23. doi:10.1016/j.jconrel.2017.02.011http://dx.doi.org/10.1016/j.jconrel.2017.02.011

Wiechers J W. Pharm Weekbl, 1989, 11: 185-189. doi:10.1007/bf01959410http://dx.doi.org/10.1007/bf01959410

Williams A C, Barry B W. Adv Drug Delivery Rev, 2004, 56(5): 603-618. doi:10.1016/j.addr.2003.10.025http://dx.doi.org/10.1016/j.addr.2003.10.025

Liu D P, Zhang Y, Jiang G H, Yu W J, Xu B, Zhu J Y. ACS Biomater Sci Eng, 2018, 4(5): 1687-1695

Chen M C, Ling M H, Lai K, Pramudityo E. Biomacromolecules, 2012, 13: 4022-4031. doi:10.1021/bm301293dhttp://dx.doi.org/10.1021/bm301293d

Larraneta E, Lutton R E M, Woolfson A D, Donnelly R F. Mater Sci Eng R, 2016, 104: 1-32. doi:10.1016/j.mser.2016.03.001http://dx.doi.org/10.1016/j.mser.2016.03.001

Henry S, McAllister A V, Allen M G, Prausnitz M R. J Pharm Sci, 1998, 87(8): 922-925. doi:10.1021/js980042+http://dx.doi.org/10.1021/js980042+

Liu S, Jin M N, Quan Y S, Kamiyama F, Katsumi H, Sakane T, Yamamoto A. J Control Release, 2012, 161: 933-941. doi:10.1016/j.jconrel.2012.05.030http://dx.doi.org/10.1016/j.jconrel.2012.05.030

Hao Y, Chen Y W, He X L, Yang F, Han R X, Yang C L, Li W, Qian Z Y. Bioact Mater, 2020, 5: 542-552. doi:10.1016/j.bioactmat.2020.05.005http://dx.doi.org/10.1016/j.bioactmat.2020.05.005

Duong H T T, Yin Y, Thambi T, Nguyen T L, Phan V H G, Lee M S, Lee J E, Kim J, Jeong J H, Lee D S. Biomaterials, 2018, 185: 13-24. doi:10.1016/j.biomaterials.2018.09.008http://dx.doi.org/10.1016/j.biomaterials.2018.09.008

Than A, Duong P K, Zan P, Liu J J, Leow M K, Chen P. Small, 2020, 16(31): 2002872. doi:10.1002/smll.202002872http://dx.doi.org/10.1002/smll.202002872

Jeon E Y, Lee J, Kim B J, Joo K I, Kim K H, Lim G, Cha H J. Biomaterials, 2019, 222: 119439. doi:10.1016/j.biomaterials.2019.119439http://dx.doi.org/10.1016/j.biomaterials.2019.119439

Samant P P, Prausnitz M R. Proc Natl Acad Sci U S A, 2018, 115(18): 4583-4588. doi:10.1073/pnas.1716772115http://dx.doi.org/10.1073/pnas.1716772115

Martanto W, Davis S P, Holiday N R, Wang J, Gill H S, Prausnitz M R. Pharm Res, 2004, 21: 947-952. doi:10.1023/b:pham.0000029282.44140.2ehttp://dx.doi.org/10.1023/b:pham.0000029282.44140.2e

Baek S H, Shin J H, Kim Y C. Biomed Microdevices, 2017, 19: 2. doi:10.1007/s10544-016-0144-1http://dx.doi.org/10.1007/s10544-016-0144-1

McAllister D V, Wang P M, Davis S P, Park J H, Canatella P J, Allen M G, Prausnitz M R. Proc Natl Acad Sci U S A, 2003, 100(24): 13755-13760. doi:10.1073/pnas.2331316100http://dx.doi.org/10.1073/pnas.2331316100

Yu W J, Jiang G H, Zhang Y, Liu D P, Xu bin, Zhou J Y. Mater Sci Eng C, 2017, 80: 187-196. doi:10.1016/j.msec.2017.05.143http://dx.doi.org/10.1016/j.msec.2017.05.143

Jin X, Zhu D D, Chen B Z, Ashfaq M, Guo X D. Adv Drug Delivery Rev, 2018, 127: 119-137. doi:10.1016/j.addr.2018.03.011http://dx.doi.org/10.1016/j.addr.2018.03.011

Indermun S, Luttge R, Choonara Y E, Kumar P, Toit L C, Modi G, Pillay V. J Control Release, 2014, 185: 130-138. doi:10.1016/j.jconrel.2014.04.052http://dx.doi.org/10.1016/j.jconrel.2014.04.052

Sharma S, Hatware K, Bhadane P, Sindhikar S, Mishra D K. Mater Sci Eng C, 2019, 103: 109717. doi:10.1016/j.msec.2019.05.002http://dx.doi.org/10.1016/j.msec.2019.05.002

Ye Y Q, Yu J C, Wen D, Kahkoska A R, Gu Z. Adv Drug Delivery Rev, 2018, 127: 106-118. doi:10.1016/j.addr.2018.01.015http://dx.doi.org/10.1016/j.addr.2018.01.015

Narayanan S P, Raghavan S. Int J Adv Manuf Tech, 2017, 93: 407-422

Choi S, Kim Y C, Park J H, Hutcheson J, Gill H S, Yoon Y, Prausnitz M R, Allen M G. Biomed Microdevices, 2010, 12: 263-273. doi:10.1007/s10544-009-9381-xhttp://dx.doi.org/10.1007/s10544-009-9381-x

Cai B, Bredenberg S, Engqvist H. J Mater Chem B, 2014, 2: 5992-5998. doi:10.1039/c4tb00764fhttp://dx.doi.org/10.1039/c4tb00764f

Cormier M, Johnson B, Ameri M, KofiNyam, LuzLibiran, Zhang D D, Daddona P. J Control Release, 2004, 97(3): 503-511. doi:10.1016/s0168-3659(04)00171-3http://dx.doi.org/10.1016/s0168-3659(04)00171-3

Gill H S, Prausnitz M R. J Control Release, 2007, 117(2): 227-237. doi:10.1016/j.jconrel.2006.10.017http://dx.doi.org/10.1016/j.jconrel.2006.10.017

Yu W J, Jiang G H, Zhang Y, Liu D P, Xu B, Zhou J Y. Mate Sci Eng C, 2017, 80(1): 187-196. doi:10.1016/j.msec.2017.05.143http://dx.doi.org/10.1016/j.msec.2017.05.143

Zhang Y, Jiang G H, Yu W J, Liu D P, Xu B. Mater Sci Eng C, 2018, 85(1): 18-26. doi:10.1016/j.msec.2017.12.006http://dx.doi.org/10.1016/j.msec.2017.12.006

Xie X, Pascual C, Lieu C, Oh S, Wang J, Zou B, Xie J L, Li Z H, Xie J, Yeomans D C, Wu M X, Xie X S. ACS Nano, 2017, 11: 395-406. doi:10.1021/acsnano.6b06104http://dx.doi.org/10.1021/acsnano.6b06104

Chen M C, Huang S F, Lai K Y, Ling M H. Biomaterials, 2013, 34: 3077-3086. doi:10.1016/j.biomaterials.2012.12.041http://dx.doi.org/10.1016/j.biomaterials.2012.12.041

Li W, Terry R N, Tang J, Feng M R, Schwendeman S P, Prausnitz M R. Nat Biomed Eng, 2019, 3: 220-229. doi:10.1038/s41551-018-0337-4http://dx.doi.org/10.1038/s41551-018-0337-4

Lopez-Ramirez M A, Soto F, Wang C, Rueda R, Shukla S, Silva-Lopez C, Kupor D, McBride D A, Pokorski J K, Nourhani A, Steinmetz N F, Shah N J, Wang J. Adv Mater, 2020, 32: 1905740. doi:10.1002/adma.201905740http://dx.doi.org/10.1002/adma.201905740

Chang H, Chew S W T, Zheng M J, Lio D C S, Wiraja C, Mei Y, Ning X Y, Cui M Y, Than A, Shi P, Wang D G, Pu K Y, Chen P, Liu H Y, Xu C J. Nat Biomed Eng, 2021, 5: 1008-1018. doi:10.1038/s41551-021-00720-1http://dx.doi.org/10.1038/s41551-021-00720-1

Bae1 W G, Ko H, So J Y, Yi H, Lee C H, Lee D H, Ahn Y J, Lee S H, Lee K, Jun J, Kim H H, Jeon N L, Jung W, Song C S, Kim T, Kim Y C, Jeong H E. Sci Transl Med, 2019, 11: eaaw3329

Fu X, Zhang X X, Huang D Q, Mao L, Qiu Y D, Zhao Y J. Chem Eng J, 2022, 431: 133362. doi:10.1016/j.cej.2021.133362http://dx.doi.org/10.1016/j.cej.2021.133362

Zhang X X, Wang F Y, Yu Y R, Chen G P, Shang L, Zhao Y J. Sci Bull, 2019, 64: 1110-1117. doi:10.1016/j.scib.2019.06.016http://dx.doi.org/10.1016/j.scib.2019.06.016

Chen M C, Lin Z W, Ling M H. ACS Nano, 2016, 10: 93-101. doi:10.1021/acsnano.5b05043http://dx.doi.org/10.1021/acsnano.5b05043

Song G, Sun Y F, Liu T Q, Zhang X Y, Zeng Z Y, Wang R F, Li P F, Li C H, Jiang G H. Chem Eng J, 2021, 426(15): 130790. doi:10.1016/j.cej.2021.130790http://dx.doi.org/10.1016/j.cej.2021.130790

Wang C, Ye Y Q, Hochu G M, Sadeghifar H, Gu Z. Nano Lett, 2016, 16: 2334-2340. doi:10.1021/acs.nanolett.5b05030http://dx.doi.org/10.1021/acs.nanolett.5b05030

Kim N W, Kim S Y, Lee J E, Yin Y, Lee J H, Lim S Y, Kim E S, Duong H T T, Kim H K, Kim S, Kim J E, Lee D S, Kim J, Lee M S, Lim Y T, Jeoong J H. ACS Nano, 2018, 12: 9702-9713. doi:10.1021/acsnano.8b04146http://dx.doi.org/10.1021/acsnano.8b04146

Boopathy A V, Mandal A, Kulp D W, Menis S, Bennett N R, Watkins H C, Wang W, Martin J T, Thai N T, He Y P, Schief W R, Hammond P T, Irvine, D J. Proc Natl Acad Sci U S A, 2019, 116(33): 16473-16478. doi:10.1073/pnas.1902179116http://dx.doi.org/10.1073/pnas.1902179116

Ling M H, Chen M C. Acta Biomater, 2013, 9: 8952-8961. doi:10.1016/j.actbio.2013.06.029http://dx.doi.org/10.1016/j.actbio.2013.06.029

Liu S, Wu D, Quan, Y S, Kamiyama F, Kusamori K, Katsumi H, Sakane T, Yamamoto A. Mol Pharmaceutics, 2016, 13: 272-279. doi:10.1021/acs.molpharmaceut.5b00765http://dx.doi.org/10.1021/acs.molpharmaceut.5b00765

Yang S X, Wu F, Liu J G, Fan G R, Welsh W, Zhu H, Jin T. Adv Funct Mater, 2015, 25: 4633-4641. doi:10.1002/adfm.201500554http://dx.doi.org/10.1002/adfm.201500554

Chen B Z, Zhang L Q, Xia Y Y, Zhang X P, Guo X D. Sci Adv, 2020, 6(28): eaba7260. doi:10.1126/sciadv.aba7260http://dx.doi.org/10.1126/sciadv.aba7260

Xu B, Cao Q Y, Zhang Y, Yu W J, Zhu J Y, Liu D P, Jiang G H. ACS Biomater Sci Eng, 2018, 4(7): 2473-2483. doi:10.1021/acsbiomaterials.8b00626http://dx.doi.org/10.1021/acsbiomaterials.8b00626

Hu X L, Yu J C, Qian C G, Lu Y, Kahkoska A R, Xie Z G, Jing X B, Buse J B, Gu Z. ACS Nano, 2017, 11: 613-620. doi:10.1021/acsnano.6b06892http://dx.doi.org/10.1021/acsnano.6b06892

Jiang G H, Xu Bin, Zhu J Y, Zhang Y, Liu T Q, Song G. Biomed Phys Eng Express, 2019, 5(4): 045038. doi:10.1088/2057-1976/ab3202http://dx.doi.org/10.1088/2057-1976/ab3202

Song G, Jiang G H, Liu T Q, Zhang X Y, Zeng Z Y, Wang R F, Li P F, Yang Y H. ACS Biomater Sci Eng, 2020, 6(7): 4116-4125. doi:10.1021/acsbiomaterials.0c00793http://dx.doi.org/10.1021/acsbiomaterials.0c00793

Zhang Y, Chai D N, Gao M Y, Yu W J, Liu D P, Xu B, Jiang G H. Int J Polym Mater Polym Biomater, 2019, 68(14): 850-858. doi:10.1080/00914037.2018.1517347http://dx.doi.org/10.1080/00914037.2018.1517347

Zhang Y Q, Feng P J, Yu J C, Yang J, Zhao J C, Wang J Q, Shen Q D, Gu Z. Adv Ther, 2018, 1: 1870006. doi:10.1002/adtp.201870006http://dx.doi.org/10.1002/adtp.201870006

Yu J C, Zhang Y Q, Ye Y Q, DiSanto R, Sun W J, Ranson D, Ligler F S, Buse J B, Gu Z. Proc Natl Acad Sci U S A, 2015, 112(27): 8260-8265. doi:10.1073/pnas.1505405112http://dx.doi.org/10.1073/pnas.1505405112

Ye Y Q, Yu J C, Wang C, Nguyen N Y, Walker G M, Buse J B, Gu Z. Adv Mater, 2016, 28(16): 3115-3121. doi:10.1002/adma.201506025http://dx.doi.org/10.1002/adma.201506025

Xu B, Jiang G H, Yu W J, Liu D P, Zhang Y, Zhou J Y, Sun S Q, Liu Y K. J Mater Chem B, 2017, 5: 8200-8208. doi:10.1039/c7tb02082ahttp://dx.doi.org/10.1039/c7tb02082a

Yu W J, Jiang G H, Zhang Y, Liu D P, Xu B, Zhou J Y. J Mater Chem B, 2017, 5: 9507-9513. doi:10.1039/c7tb02236khttp://dx.doi.org/10.1039/c7tb02236k

Yang B, Fang X E, Kong J L. ACS Appl Mater Interfaces, 2019, 11: 38448-38458. doi:10.1021/acsami.9b12244http://dx.doi.org/10.1021/acsami.9b12244

Heikenfeld J, Jajack A, Feldman B J, Granger S W, Gaitonde S, Begtrup G, Katchman B. Nat Biotechnol, 2019, 34: 407-419. doi:10.1038/s41587-019-0040-3http://dx.doi.org/10.1038/s41587-019-0040-3

Sulaiman D A, Chang J Y H, Bennett N R, Topouzi H, Higgins C A, Irvine D J, Ladame S. ACS Nano, 2019, 13:9620-9628

Chang H, Zheng M J, Yu X J, Than A, Seeni R Z, Kang R J, Tian J Q, Khanh D P, Liu L B, Chen P, Xu C J. Adv Mater, 2017, 29: 1702243. doi:10.1002/adma.201702243http://dx.doi.org/10.1002/adma.201702243

Zheng M, Wang Z F, Chang H, Wang L L, Chew S W T, Lio D C S, Cui M Y, Liu L B, Tee B C K, Xu C J. Adv Healthc Mater, 2020, 1901683. doi:10.1002/adhm.201901683http://dx.doi.org/10.1002/adhm.201901683

Zhang X X, Chen G P, Bian F K, Cai L J, Zhao Y J. Adv Mater, 2019, 34: 1902825. doi:10.1002/adma.201902825http://dx.doi.org/10.1002/adma.201902825

Yang B, Fang X, Kong J. Adv Funct Mater, 2020, 30: 2000591. doi:10.1002/adfm.202000591http://dx.doi.org/10.1002/adfm.202000591

Lee H, Song C, Hong Y S, Kim M S, Cho H R, Kang T, Shin K, Choi S H, Hyeon T, Kim D H. Sci Adv, 2017, 3(3): e1601314. doi:10.1126/sciadv.1601314http://dx.doi.org/10.1126/sciadv.1601314

Li X L, Huang X S, Mo J S, Wang H, Huang Q Q, Yang C, Zhang T, Chen H J, Hang T, Liu F M, Jiang L L, Wu Q N, Li H B, Hu N, Xie X. Adv Sci, 2021, 8(16): 2100827. doi:10.1002/advs.202100827http://dx.doi.org/10.1002/advs.202100827

Yang G, Chen, Q, Wen D, Chen Z W, Wang J Q, Chen G J, Wang Z J, Zhang X D, Zhang Y Q, Hu Q Y, Zhang L, Gu Z. ACS Nano, 2019, 13: 4354-4360. doi:10.1021/acsnano.8b09573http://dx.doi.org/10.1021/acsnano.8b09573

Zhang Y Q, Liu Q M, Yu J C, Yu S J, Wang J Q, Qiang L, Gu Z. ACS Nano, 2017, 11: 9233-9230. doi:10.1021/acsnano.7b04348http://dx.doi.org/10.1021/acsnano.7b04348

Bao C, Li Z K, Liang S, Hu Y L, Wang X Y, Fang B, Wang P J, Chen S N, Li Y. Adv Funct Mater, 2021, 2011130. doi:10.1002/adfm.202011130http://dx.doi.org/10.1002/adfm.202011130

Zhang X X, Chen G P, Liu Y X, Sun L Y, Sun L Y, Zhao Y J. ACS Nano, 2020, 14(5): 5901-5908. doi:10.1021/acsnano.0c01059http://dx.doi.org/10.1021/acsnano.0c01059

Lee K J, Xue Y, Lee J, Kim H J, Liu Y W, Tebon P, Sarikhani E, Sun W J, Zhang S M, Haghniaz R, Çelebi-Saltik B, Zhou X W, Ostrovidov S, Ahadian S, Ashammakhi N, Dokmeci M R, Khademhosseini A. Adv Funct Mater, 2020, 30(23): 2000086. doi:10.1002/adfm.202000086http://dx.doi.org/10.1002/adfm.202000086

Li W, Tang J, Terry R N, Li S, Brunie A, Callahan R L, Noel R K, Rodriguez C A, Schwendeman S P, Prausnitz M R. Sci Adv, 2019, 5(11): eaaw8145. doi:10.1126/sciadv.aaw8145http://dx.doi.org/10.1126/sciadv.aaw8145

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