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三元共轭聚合物用于NIR-II荧光成像及光热/光动力联合治疗
A Ternary Conjugated Polymer for NIR-II Fluorescence Imaging and Photothermal/Photodynamic Combination Therapy
- 高分子学报 2022年53卷第8期 页码：913-922
- 作者机构：
1.南京邮电大学 有机电子与信息显示国家重点实验室 信息材料与纳米技术研究院 南京 210023
2.南京理工大学 医院 南京 210094
- 作者简介：
E-mail: iamflu@njupt.edu.cn;
iamqwang@njupt.edu.cn
- 基金信息：国家自然科学基金(基金号 ┣22175098);21975131┫;江苏省博士后科研资助计划(2021K114B);江苏省高等学校自然科学研究面上项目(21KJB430031);南京邮电大学国自基金孵化项目(NY220198)
DOI：10.11777/j.issn1000-3304.2022.22054
中图分类号：纸质出版日期：2022-08-20，
网络出版日期：2022-06-20，
收稿日期：2022-02-25，
录用日期：2022-03-31
- 稿件说明：
移动端阅览
桑若愚,夏辉,熊炎威等.三元共轭聚合物用于NIR-II荧光成像及光热/光动力联合治疗[J].高分子学报,2022,53(08):913-922.
Sang Ruo-yu,Xia Hui,Xiong Yan-wei,et al.A Ternary Conjugated Polymer for NIR-II Fluorescence Imaging and Photothermal/Photodynamic Combination Therapy[J].ACTA POLYMERICA SINICA,2022,53(08):913-922.
桑若愚,夏辉,熊炎威等.三元共轭聚合物用于NIR-II荧光成像及光热/光动力联合治疗[J].高分子学报,2022,53(08):913-922. DOI： 10.11777/j.issn1000-3304.2022.22054.
Sang Ruo-yu,Xia Hui,Xiong Yan-wei,et al.A Ternary Conjugated Polymer for NIR-II Fluorescence Imaging and Photothermal/Photodynamic Combination Therapy[J].ACTA POLYMERICA SINICA,2022,53(08):913-922. DOI： 10.11777/j.issn1000-3304.2022.22054.
摘要
为获得同时具有光热性能、光动力性能及近红外二区(NIR-II，1000-1700 nm)荧光发射的共轭聚合物，将一种电子受体单元和2种电子供体单元进行共聚得到一种新型三元共轭聚合物，进一步利用两亲性Pluronic F127作为包覆材料，通过简单的纳米沉淀方法制备得到基于该共轭聚合物的水溶性纳米颗粒. 该纳米颗粒具有优异的生物相容性、较好的稳定性、高的近红外一区(NIR-I，650~900 nm)光学吸收及NIR-II荧光发射能力. 在单一激光照射下，该纳米颗粒可以同时产生过高热、活性氧及NIR-II荧光信号，可用于NIR-II荧光成像指导下的肿瘤光热/光动力联合治疗.
Abstract
In order to simultaneously achieve photothermal properties
photodynamic effects and second near-infrared (NIR-II 1000-1700 nm) fluorescence emission of conjugated polymers
herein a novel ternary conjugated polymer (BDP) was designed and synthesized by copolymerization of an electron-withdrawing monomer diketopyrrolopyrrole and two electron-donating monomers (benzodithiophene derivatives and 1
10-phenanthroline). Then water-soluble nanoparticles (BDP NPs) were further prepared by self-assembling with amphiphilic Pluronic F127 through nanoprecipitation method. The nanoparticles with a diameter of around 90 nm exhibited excellent stability in aqueous solution. The absorption and emission peaks of BDP NPs were determined to be 735 nm and 1039 nm
respectively. The mass extinction coefficient of the nanoparticles was as high as 4.67 mL/(mg·cm) the fluorescence quantum yield of BDP NPs was measured to be 0.62% by using IR-26 as a reference
and the photothermal conversion efficiency was 18.2%. Under 730 nm laser ir
radiation
the temperature of BDP NPs (150 μg/mL) can reach 64 ℃
which was high enough for photothermal therapy. Besides
the BDP NPs also produce reactive oxygen species with the same laser
which can be used for photodynamic therapy. Cell experiments confirmed that there was no obvious dark toxicity to both NIH3T3 cells and HeLa cells. While under NIR laser irradiation
strong phototoxicity toward cancer cells was observed
indicating the high therapeutic efficacy with the combination therapy. After intravenous injection of BDP NPs
the blood vessels in living mice can be observed which confirmed the high resolution of NIR-II imaging. Importantly
the BDP NPs can accumulate at the tumor sites at 12 h post-injection
indicating the possibility of NIR-II imaging guided combination therapy
in vivo
. Overall the obtained BDP NPs with high biocompatibility strong absorption in the first near-infrared (NIR-I
650-900 nm) range
intense emission in NIR-II region
and the ability to produce reactive oxygen species and hyperthermia were
excellent candidate for tumor diagnosis and phototherapy. In addition
this work also provides a promising method for the rational design of conjugated polymer-based high performance phototheranostic nanoplatforms.
关键词
共轭聚合物光热治疗光动力治疗联合治疗NIR-II荧光成像
Keywords
Conjugated polymerPhotothermal therapyPhotodynamic therapyCombination therapyNIR-II fluorescence imaging
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