光功能基元J-型序构的高分子诊疗材料

张好; 李昌华

doi:10.11777/j.issn1000-3304.2022.22058

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光功能基元J-型序构的高分子诊疗材料

专论 | 更新时间：2024-10-08

- 光功能基元J-型序构的高分子诊疗材料
- Polymeric Materials with J-Stacked Photo-functional Moieties for Disease Diagnosis and Therapy
- 高分子学报 2022年53卷第7期页码：769-783
- 作者机构：
  
  南开大学药物化学生物学国家重点实验室天津 300071
- 作者简介：
  
  [ "李昌华，男，1985年生. 南开大学药物化学生物学国家重点实验室研究员、药学院教授. 2007年获中国科学技术大学学士学位，2012年获中国科学技术大学博士学位(导师：刘世勇教授)，读博期间在德国美因茨大学学习1年(导师：Manfred Schmidt教授)，2012~2015年在日本东京大学和RIKEN从事博士后研究(合作导师：Takuzo Aida教授)，2015年开始在南开大学任教至今. 2021年获得国家自然科学基金优秀青年科学基金项目资助. 主要从事有机高分子/超分子光活性诊疗材料的研究." ]
- 基金信息：
  
  国家自然科学基金(基金号 52122305)
- DOI：10.11777/j.issn1000-3304.2022.22058
  中图分类号：
- 纸质出版日期：2022-07-20，
  
  网络出版日期：2022-05-18，
  
  收稿日期：2022-02-28，
  
  录用日期：2022-04-15
- 稿件说明：
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张好,李昌华.光功能基元J-型序构的高分子诊疗材料[J].高分子学报,2022,53(07):769-783.

Zhang Hao,Li Chang-hua.Polymeric Materials with J-Stacked Photo-functional Moieties for Disease Diagnosis and Therapy[J].ACTA POLYMERICA SINICA,2022,53(07):769-783.
张好,李昌华.光功能基元J-型序构的高分子诊疗材料[J].高分子学报,2022,53(07):769-783. DOI： 10.11777/j.issn1000-3304.2022.22058.

Zhang Hao,Li Chang-hua.Polymeric Materials with J-Stacked Photo-functional Moieties for Disease Diagnosis and Therapy[J].ACTA POLYMERICA SINICA,2022,53(07):769-783. DOI： 10.11777/j.issn1000-3304.2022.22058.

摘要

染料分子有序的J-型聚集会产生新的独特光物理性质，使其成为一种构筑高性能疾病诊疗材料的有力手段. 光功能基元J-型序构的高分子诊疗材料充分整合了染料J-聚集体诸多优异的光学性能以及聚合物的响应性、多功能集成性和生物相容性等众多优良特性. 本文主要总结了该领域以本课题组为代表的近期开展的一些研究工作，具体包括：(1)构筑水相稳定的J-聚集体纳米材料，使其在复杂生命体系中保持必要的J-型排列；(2)利用聚合物辅助纳米J-聚集体实现形貌调控与重塑，以提升其肿瘤诊疗性能；(3)聚合物纳米J-聚集体的性能优化与癌症诊疗应用，包括可穿透深层组织的近红外-Ⅱ成像、克服光漂白的光热治疗、疾病标志物激活的精准光动力治疗等. 功能基元J-型序构策略为光诊疗材料的开发带来了新的设计原理和制备方法，为探索具有更高性能的高分子/超分子光功能诊疗材料提供了广阔的设计空间.

Abstract

Controlling dye molecules into a highly ordered J-type sliding arrangement/packing induces exciton coupling to enable new photophysical properties

which makes J-aggregation a powerful tool to construct efficient photoactive materials for disease diagnosis and treatment. In particular

the significant red-shift of absorption and emission peak

enhanced absorbanc

and narrowed spectral lines enable deep tissue penetration of photons

high photon utilization

and multi-channels optical diagnosis and therapy

respectively. However

J-aggregates have difficulty in maintaining the necessary dye alignment in complex living settings

impeding their biomedical applications. Furthermore

the difficulty in forming nanostructures with appropriate morphology and size is another obstacle to the

in vivo

applications of J-aggregates. Polymeric nanoassemblies formed by self-assembly of amphiphilic block copolymers have been widely used as drug delivery vehicles due to their intriguing properties

such as stimuli responsiveness

multifunctional integration

and biocompatibility. Therefore

covalent conjugation with polymers and/or encapsulation by polymer assemblies provide an efficient strategy for constructing optical and colloidal stable J-aggregate materials for biological applications. In this review

we summarize recent advances in polymeric materials with J-stacked dyes for disease diagnosis and therapy

including: (i) establishing facile strategies to construct water-stable polymeric or supramolecular J-aggregate nanomaterials to maintain the necessary J-type arrangement in complex living systems

(ii) developing robust methods to remodel J-aggregates nanoassemblies with the assistance of polymers to obtain nano J-aggregates with desired morphology and size to improve their

in vivo

performances in tumor diagnosis and therapy

and (iii) devising and constructing novel polymeric nano-J-aggregates with remarkable performances in cancer diagnostic and therapeutic applications

such as near-infrared-Ⅱ imaging agents with high tissue penetration depth

non-photobleaching photothermal agents for cancer photothermal therapy

and activatable photosensitizers in response to disease biomarkers for precise photodynamic therapy. In light of the unique photophysical and photochemical properties of J-aggregates and fascinating properties of polymers

this new

type of polymeric materials with J-stacked photo-functional moieties bring new design principles and preparation methods for the development of phototherapeutic materials

and opens a gateway to the explore polymer/supramolecular phototherapeutic materials with higher performance.

关键词

光活性功能高分子诊疗高分子材料非共价键作用J-聚集分子自组装

Keywords

Photoactive functional polymerDiagnostic and therapeutic polymer materialNoncovalent interactionJ-aggregationMolecular self-assembly

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