聚集诱导发光高分子在光学诊疗应用中的研究进展

李丹; 孙盼盼; 李建高; 燕赛赛; 王东; 唐本忠

doi:10.11777/j.issn1000-3304.2022.22079

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聚集诱导发光高分子在光学诊疗应用中的研究进展

综述 | 更新时间：2024-10-08

- 聚集诱导发光高分子在光学诊疗应用中的研究进展
- Recent Advances of Polymers with Aggregation-induced Emission Characteristics in Phototheranostics
- 高分子学报 2022年53卷第7期页码：856-872
- 作者机构：
  
  1.深圳大学材料学院 AIE研究中心深圳 518060
  2.香港中文大学(深圳)理工学院深圳 518172
- 作者简介：
  
  [ "王东，男，1985年生. 深圳大学特聘教授. 分别获得兰州大学和法国波尔多大学博士学位，之后先后在加拿大多伦多大学和香港科技大学从事博士后研究，于2018年4月加入深圳大学材料学院. 现任深圳大学AIE研究中心主任(执行)、深圳大学青年科学家联谊会副理事长、科学出版社《聚集诱导发光丛书》副总主编、中国化学会分子聚集发光专业委员会委员、《Aggregate》《发光学报》和《Exploration》期刊青年编委. 获得国家自然科学基金优秀青年科学基金、广东省杰出青年科学基金、深圳市优秀青年科学基金等项目资助. 入选《Biomaterial Science》《Science China Chemistry》新锐科学家. 主要研究方向为聚集诱导发光(AIE)材料的开发，及其在传感、生物成像和治疗等方面的应用研究." ]
  [ "唐本忠，男，1957年生. 现任香港中文大学(深圳)理工学院院长，深圳大学AIE研究中心荣誉主任. 1982年本科毕业于华南理工大学，1985、1988年在日本京都大学分别获硕士和博士学位，1989~1994年在加拿大多伦多大学从事博士后研究，1994年加入香港科技大学从事学术研究工作，2008年晋升为讲席教授. 2007年获国家自然科学二等奖、Croucher基金会高级研究员奖、中国化学会王葆仁奖和Elsevier杂志社冯新德奖. 2009年当选中国科学院院士. 2012年获Science China Chemistry杰出贡献奖. 2013年入选英国皇家化学会会士. 2017年获国家自然科学奖一等奖以及何梁何利基金科学技术进步奖，并获得科技盛典-CCTV 2018年度科技创新人物. 期刊《Aggregate》主编以及二十多家国际科学杂志顾问、编委或客座编辑等. 主要从事高分子科学和聚集诱导发光(AIE)的研究." ]
- 基金信息：
  
  国家自然科学基金(基金号 22005194)
- DOI：10.11777/j.issn1000-3304.2022.22079
  中图分类号：
- 纸质出版日期：2022-07-20，
  
  网络出版日期：2022-06-06，
  
  收稿日期：2022-03-11，
  
  修回日期：2022-04-11，
- 稿件说明：
移动端阅览
李丹,孙盼盼,李建高等.聚集诱导发光高分子在光学诊疗应用中的研究进展[J].高分子学报,2022,53(07):856-872.

Li Dan,Sun Pan-pan,Li Jian-gao,et al.Recent Advances of Polymers with Aggregation-induced Emission Characteristics in Phototheranostics[J].ACTA POLYMERICA SINICA,2022,53(07):856-872.
李丹,孙盼盼,李建高等.聚集诱导发光高分子在光学诊疗应用中的研究进展[J].高分子学报,2022,53(07):856-872. DOI： 10.11777/j.issn1000-3304.2022.22079.

Li Dan,Sun Pan-pan,Li Jian-gao,et al.Recent Advances of Polymers with Aggregation-induced Emission Characteristics in Phototheranostics[J].ACTA POLYMERICA SINICA,2022,53(07):856-872. DOI： 10.11777/j.issn1000-3304.2022.22079.

摘要

高分子因其优异的光学特性、良好的生物相容性和分子结构易于调控等优势，在光学诊疗领域表现出巨大应用潜力. 然而，传统荧光分子的聚集导致荧光淬灭现象限制了其生物应用. 聚集诱导发光(AIE)分子因其聚集态高效发光的优势而备受关注. 本文从AIE高分子的构建出发，重点介绍了D-A型共轭聚合物的构建策略、构-效关系以及相对于小分子的性能和应用优势，并从生物成像、肿瘤诊疗和抗菌三个方面总结了AIE高分子在光学诊疗领域的最新研究进展. 生物成像方面主要总结了NIR-II区AIE高分子在深部组织高分辨率荧光成像中的应用；肿瘤诊疗方面主要介绍了AIE高分子在光动力治疗、光热治疗及联合治疗中的应用；以及介绍了AIE高分子在细菌感染光动力治疗中的应用. 最后对AIE高分子在光学诊疗领域的未来发展前景进行了展望.

Abstract

Phototheranostics

as an emerging treatment integrating the functions of light-driven diagnostic imaging and therapy

has aroused extensive attention for both fundamental research and clinical application in recent years because of its advantages of high temporal and spatial selectivity

low side effects

small trauma and high controllability. The conjugated polymers have distinct advantages including excellent optical properties

easy chemical structure regulation

good biocompatibility and solution processability

showing great potential application in the field of phototheranostics. However

traditional fluorescent molecules including the conjugated polymers suffer from the phenomenon of aggregation-caused quenching (ACQ) in aggregate state resulted from their rigid planar structures

thus hindering their biological applications. Luminogens with aggregation-induced emission (AIE) characteristics have attracted much attention because of their high fluorescence quantum efficiency in aggregate. This review is aimed to summarize the state-of-the-art advancements of AIE polymers in phototheranostics

especially the D-A type conjugated polymers

involving the construction strategies of AIE polymers and their applications in three aspects of biological imaging

tumor diagnosis and therapy

and bacterial eradication. According to the practical applications

the different requirements of construction strategies for AIE polymers

as well as the comparisons of the structure and properties advantages between the small molecules and polymers are also discussed. For biological imaging

the review is mainly focused on the development of AIE polymers with NIR-II fluorescence emission and high brightness to achieve high-resolution fluorescence imaging in deep tissues. In the aspect of tumor diagnosis and treatment

the review illustrates the AIE polymers with great advantages compared with small molecules in photon absorption and photosensitization performance

and their applications in photodynamic therapy

photothermal therapy and combined therapy. Also

the applications of AIE polymers for photodynamic therapy of bacterial infections are illustrated. Although the development of AIE polymers have lagged behind that of small molecules mainly due to their complex molecular structures and more difficult AIE mechanism studies

it is necessary to pay more attention to pushing forward the studies on AIE polymers and having in-depth understanding about structure-properties relationship. Additionally

the future development in the field of AIE polymers is prospected at the end of this review.

关键词

聚集诱导发光高分子光学诊疗

Keywords

Aggregation-induced emissionPolymerPhototheranostics

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