生物医用高分子囊泡

石隽秋; 陈帅; 朱云卿; 杜建忠

doi:10.11777/j.issn1000-3304.2022.22268

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生物医用高分子囊泡

专论 | 更新时间：2023-11-27

- 生物医用高分子囊泡
- Polymer Vesicles for Biomedical Applications
- 高分子学报 2023年54卷第3期页码：314-326
- 作者机构：
  
  1.同济大学材料科学与工程学院高分子材料系上海 201804
  2.同济大学附属上海市第四人民医院妇产科上海 200434
- 作者简介：
  
  [ "朱云卿，男，1986年生. 2013、2016年分别在同济大学和英国帝国理工大学获得硕士和博士学位. 2017~2019年分别在英国牛津大学和帝国理工大学从事博士后研究工作，2019年6月入职同济大学. 同济大学青年百人计划研究员，博士生导师. 主要从事环境友好高分子材料研究，主持了国家自然科学基金青年科学基金、面上项目等. 以第一/通讯作者在《Nature》《J. Am. Chem. Soc.》《Angew. Chem. Int. Ed.》等期刊发表SCI论文20多篇,包括2篇ESI热点论文. 曾获帝国理工信托基金奖、英国化工协会Messel奖等奖励." ]
  [ "杜建忠，男，1975年生. 中国科学院化学研究所博士(2004年)，谢菲尔德大学、剑桥大学博士后(2004~2010年)，洪堡学者(2006年)，东方学者(2009年). 同济大学长聘特聘教授、学术委员会委员、高分子材料系主任、博士生导师. 英国皇家化学会会士、中国化学会高分子学科委员会委员、中国生物材料学会生物医用高分子材料分会委员、《Biomacromolecules》等期刊顾问编委. 主要研究领域为高分子化学与物理、生物医用材料，已在《J. Am. Chem. Soc.》等期刊发表140多篇论文，获国家杰出青年科学基金(2019年)资助、国家科技进步奖二等奖(3/15)、中国侨界贡献奖一等奖、同济大学首届“卓越”研究生导学团队标兵、同济大学“十三五”科研工作先进个人等." ]
- 基金信息：
  
  国家自然科学基金(基金号21925505;51903190)
- DOI：10.11777/j.issn1000-3304.2022.22268
  中图分类号：
- 纸质出版日期：2023-03-20，
  
  网络出版日期：2022-10-26，
  
  收稿日期：2022-08-03，
  
  录用日期：2022-09-08
扫描看全文
石隽秋,陈帅,朱云卿等.生物医用高分子囊泡[J].高分子学报,2023,54(03):314-326.

Shi Jun-qiu,Chen Shuai,Zhu Yun-qing,et al.Polymer Vesicles for Biomedical Applications[J].ACTA POLYMERICA SINICA,2023,54(03):314-326.
石隽秋,陈帅,朱云卿等.生物医用高分子囊泡[J].高分子学报,2023,54(03):314-326. DOI： 10.11777/j.issn1000-3304.2022.22268.

Shi Jun-qiu,Chen Shuai,Zhu Yun-qing,et al.Polymer Vesicles for Biomedical Applications[J].ACTA POLYMERICA SINICA,2023,54(03):314-326. DOI： 10.11777/j.issn1000-3304.2022.22268.

摘要

高分子囊泡由于其独特的腔-膜-冠结构，在生物医用等领域具有重要应用前景. 本专论从自组装新机理/新方法和新的生物医学应用两方面总结和评述了近期生物医用高分子囊泡领域的研究进展. 前者包括构建高效包载生物大分子的囊泡的“酸诱导吸附”和“亲和强化吸引”原理、构建完全非对称冠囊泡的“胶束-囊泡转变法”、构建高级囊泡结构的“融合诱导粒子自组装”方法、可宏量制备囊泡的氨基酸环内酸酐开环聚合诱导自组装方法；后者主要介绍“以糖控糖”囊泡、治疗糖尿病溃疡囊泡、抗菌囊泡、抗癌囊泡、靶向治疗骨质疏松症囊泡和护肾血管造影囊泡. 最后，对高分子囊泡的未来发展方向进行了展望.

Abstract

Polymer vesicles have an important application prospect in biomedical and other fields due to their unique lumen-membrane-corona structure. In this feature article

we highlighted recent advance in polymer vesicles for biomedical applications

including new mechanism and methods for self-assembly

and new biomedical applications. The former includes two principles of acid-induced adsorption and affinity-enhanced attraction for preparing vesicles with ultrahigh biomacromolecular loading efficiency

"micelle to vesicle transition" strategy for preparing asymmetric vesicles

fusion-induced particle assembly to build hierarchical vesicles

and ring-opening polymerization of

-carboxyanhydride-induced self-assembly to fabricate vesicles on a large scale; the latter includes vesicles for blood glucose control

vesicles to treat diabetic ulcers

antibacterial vesicles

anticancer vesicles

bone-targeting vesicles to treat osteoporosis and renoprotective angiographic vesicles. Finally

the future development of polymer vesicles and their potential biomedical applications are forecasted.

关键词

高分子囊泡大分子自组装生物医用材料融合诱导自组装

Keywords

Polymer vesiclesMacromolecular self-assemblyBiomedical materialsFusion-induced particle assembly

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