体内自组装多肽纳米材料及其在肿瘤诊疗中的研究进展

张光叙; 乔增莹; 王浩

doi:10.11777/j.issn1000-3304.2022.22456

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体内自组装多肽纳米材料及其在肿瘤诊疗中的研究进展

综述 | 更新时间：2023-05-31

- 体内自组装多肽纳米材料及其在肿瘤诊疗中的研究进展
- Research Progress of in vivo Self-assembled Peptide Nanomaterials and Their Application in Tumor Diagnosis and Treatment
- 高分子学报 2023年54卷第6期页码：976-994
- 作者机构：
  
  1.郑州大学河南先进技术研究院郑州 450003
  2.国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室北京 100190
- 作者简介：
  
  [ "乔增莹，女，1985年生. 2007年毕业于山东大学化学专业，获理学学士学位；2012年获北京大学高分子化学与物理专业博士学位. 之后，继续在国家纳米科学中心担任助理/副研究员，2019年起在国家纳米科学中心任研究员. 2022年获得国家自然科学基金优秀青年科学基金支持，北京市科技新星. 主要研究方向为生理条件下的超分子组装、聚合肽纳米材料及其在生物医学领域的应用. E-mail: qiaozy@nanoctr.cn" ]
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2022.22456
  中图分类号：
- 纸质出版日期：2023-06-20，
  
  网络出版日期：2023-03-13，
  
  收稿日期：2022-12-30，
  
  录用日期：2023-01-25
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张光叙,乔增莹,王浩.体内自组装多肽纳米材料及其在肿瘤诊疗中的研究进展[J].高分子学报,2023,54(06):976-994.

Zhang Guang-xu,Qiao Zeng-ying,Wang Hao.Research Progress of in vivo Self-assembled Peptide Nanomaterials and Their Application in Tumor Diagnosis and Treatment[J].ACTA POLYMERICA SINICA,2023,54(06):976-994.
张光叙,乔增莹,王浩.体内自组装多肽纳米材料及其在肿瘤诊疗中的研究进展[J].高分子学报,2023,54(06):976-994. DOI： 10.11777/j.issn1000-3304.2022.22456.

Zhang Guang-xu,Qiao Zeng-ying,Wang Hao.Research Progress of in vivo Self-assembled Peptide Nanomaterials and Their Application in Tumor Diagnosis and Treatment[J].ACTA POLYMERICA SINICA,2023,54(06):976-994. DOI： 10.11777/j.issn1000-3304.2022.22456.

摘要

多肽纳米药物由于具有易于设计改造、良好的靶向性、生物相容性和较长的血液循环时间等优势，在生物医学与肿瘤诊疗中具有巨大的潜力. 近年来，利用肿瘤微环境原位构建多肽纳米材料的策略已被广泛研究，本文综述了多肽纳米材料通过不同的刺激响应(pH、酶和氧化还原等)实现体内自组装，从而对肿瘤的诊断与治疗产生的积极效果. 重点阐述了不同的刺激响应型自组装多肽纳米材料的设计合成及其在肿瘤诊疗中的应用，如对于药物递送系统中的药物富集、渗透和内吞等过程的增强作用，同时简单介绍了其在生物成像上的应用，最后对体内自组装多肽纳米材料的未来发展进行了展望.

Abstract

Peptide nanomedicines have great potential in tumor diagnosis and treatment due to their advantages of easy design and modification

good targeting

biocompatibility and long blood circulation time. In recent years

the strategy of constructing peptide nanomaterials

in situ

in the tumor microenvironment has been widely studied

and "

in vivo

self-assembly" has proven to be a promising biotechnology for disease diagnosis and treatment. Construction of

in situ

peptide-based self-assemblies at tumor or infection sites shows assembly/aggregation-induced retention (AIR) effects and enhances the biological function of nanomaterials. Peptide molecules are often driven by hydrogen bonds

van der Waals forces

electrostatic effects

etc.

to form supramolecular structures. The self-assembly behavior is often stimulated by various factors such as light

sound

enzymes

redox

etc.

to form a corresponding assembly structure. The tumor microenvironment is more complex

and researchers have designed a series of peptide nanomaterials that can respond to the special tumor microenvironment

so that the peptide nanomaterials can be assembled at the tumor site to achieve the expected therapeutic effect. The

in vivo

self-assembly strategy of peptide nanomaterials can better improve the ability of drug enrichment at target location

cell uptake of drug and drug penetration. At the same time

it has been found that peptide nanomaterials also have a gratifying effect in non-invasive biological imaging

and that this non-invasive imaging strategy has also been widely used

such as fluorescence imaging

photoacoustic imaging

etc.

Based on the current research work on peptide nanomaterials

this article reviews the effects of

in vivo

self-assembled peptide nanomaterials on the diagnosis and treatment of tumors through different stimuli (pH

enzymes

redox

etc.

)

focusing on the design and synthesis of different stimuli-responsive self-assembled peptide nanomaterials and their applications in tumor diagnosis and treatment

such as the enhancement of drug enrichment

penetration

endocytosis and other processes in drug delivery systems. At the same time

its application in biological imaging is briefly introduced

and finally the future development of self-assembled peptide nanomaterials

in vivo

is prospected.

关键词

体内自组装多肽纳米材料刺激响应性药物递送肿瘤诊疗

Keywords

In vivo self-assemblyPeptide nanomaterialsStimulation responsivenessDrug deliveryTumor diagnosis and treatment

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